Search Results - "WALTON, Zandra"

MYC, Metabolism, and Cancer by Stine, Zachary E, Walton, Zandra E, Altman, Brian J, Hsieh, Annie L, Dang, Chi V

“…The MYC oncogene encodes a transcription factor, MYC, whose broad effects make its precise oncogenic role enigmatically elusive. The evidence to date suggests…”
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR by Walton, Zandra E., Patel, Chirag H., Brooks, Rebekah C., Yu, Yongjun, Ibrahim-Hashim, Arig, Riddle, Malini, Porcu, Alessandra, Jiang, Tianying, Ecker, Brett L., Tameire, Feven, Koumenis, Constantinos, Weeraratna, Ashani T., Welsh, David K., Gillies, Robert, Alwine, James C., Zhang, Lin, Powell, Jonathan D., Dang, Chi V.

“…Recent reports indicate that hypoxia influences the circadian clock through the transcriptional activities of hypoxia-inducible factors (HIFs) at clock genes…”
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ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation by Qing, Guoliang, Li, Bo, Vu, Annette, Skuli, Nicolas, Walton, Zandra E., Liu, Xueyuan, Mayes, Patrick A., Wise, David R., Thompson, Craig B., Maris, John M., Hogarty, Michael D., Simon, M. Celeste

“…Oncogenic Myc alters mitochondrial metabolism, making it dependent on exogenous glutamine (Gln) for cell survival. Accordingly, Gln deprivation selectively…”
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Fructose-1,6-bisphosphatase opposes renal carcinoma progression by Li, Bo, Qiu, Bo, Lee, David S. M., Walton, Zandra E., Ochocki, Joshua D., Mathew, Lijoy K., Mancuso, Anthony, Gade, Terence P. F., Keith, Brian, Nissim, Itzhak, Simon, M. Celeste

“…Fructose-1,6-bisphosphatase is shown to be depleted in clear cell renal cell carcinoma (ccRCC) and inhibits ccRCC progression by antagonizing glycolytic flux…”
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MYC and metabolism on the path to cancer by Hsieh, Annie L., Walton, Zandra E., Altman, Brian J., Stine, Zachary E., Dang, Chi V.

“…•The MYC proto-oncogene is commonly deregulated and activated in human cancers.•MYC-dependent metabolism is critical for tumor growth.•MYC alters metabolism…”
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MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells by Altman, Brian J., Hsieh, Annie L., Sengupta, Arjun, Krishnanaiah, Saikumari Y., Stine, Zachary E., Walton, Zandra E., Gouw, Arvin M., Venkataraman, Anand, Li, Bo, Goraksha-Hicks, Pankuri, Diskin, Sharon J., Bellovin, David I., Simon, M. Celeste, Rathmell, Jeffrey C., Lazar, Mitchell A., Maris, John M., Felsher, Dean W., Hogenesch, John B., Weljie, Aalim M., Dang, Chi V.

“…The MYC oncogene encodes MYC, a transcription factor that binds the genome through sites termed E-boxes (5′-CACGTG-3′), which are identical to the binding…”
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MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis by Cazarin, Juliana, DeRollo, Rachel E, Shahidan, Siti Noor Ain Binti Ahmad, Burchett, Jamison B, Mwangi, Daniel, Krishnaiah, Saikumari, Hsieh, Annie L, Walton, Zandra E, Brooks, Rebekah, Mello, Stephano S, Weljie, Aalim M, Dang, Chi V, Altman, Brian J

“…The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many…”
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Current and emerging pharmacotherapies for cytokine release syndrome, neurotoxicity, and hemophagocytic lymphohistiocytosis-like syndrome due to CAR T cell therapy by Walton, Zandra E, Frigault, Matthew J, Maus, Marcela V

“…Chimeric antigen receptor (CAR) T cells have revolutionized the treatment of multiple hematologic malignancies. Engineered cellular therapies now offer similar…”
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mTOR Senses Intracellular pH through Lysosome Dispersion from RHEB by Walton, Zandra E., Brooks, Rebekah C., Dang, Chi V.

“…Acidity, generated in hypoxia or hypermetabolic states, perturbs homeostasis and is a feature of solid tumors. That acid peripherally disperses lysosomes is a…”
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Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition by Johnson, Neil, Li, Yu-Chen, Walton, Zandra E, Cheng, Katherine A, Li, Danan, Rodig, Scott J, Moreau, Lisa A, Unitt, Christine, Bronson, Roderick T, Thomas, Huw D, Newell, David R, D'Andrea, Alan D, Curtin, Nicola J, Wong, Kwok-Kin, Shapiro, Geoffrey I

“…This report identifies Cdk1's phosphorylation of BRCA1 as an important regulator of BRCA1's DNA repair function. Cdk1 inhibition renders cancer cells sensitive…”
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Improvement of a giant cell arteritis prediction model by Walton, Zandra E, Patel, Naomi J

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Inflammatory cytokines in major depressive disorder: A case–control study by Cassano, Paolo, Bui, Eric, Rogers, Andrew H, Walton, Zandra E, Ross, Rachel, Zeng, Mary, Nadal-Vicens, Mireya, Mischoulon, David, Baker, Amanda W, Keshaviah, Aparna, Worthington, John, Hoge, Elizabeth A, Alpert, Jonathan, Fava, Maurizio, Wong, Kwok K, Simon, Naomi M

“…Introduction: There is mixed evidence in the literature on the role of inflammation in major depressive disorder. Contradictory findings are attributed to lack…”
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Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis by Lau, Allison N, Curtis, Stephen J, Fillmore, Christine M, Rowbotham, Samuel P, Mohseni, Morvarid, Wagner, Darcy E, Beede, Alexander M, Montoro, Daniel T, Sinkevicius, Kerstin W, Walton, Zandra E, Barrios, Juliana, Weiss, Daniel J, Camargo, Fernando D, Wong, Kwok-Kin, Kim, Carla F

“…Metastasis is the leading cause of morbidity for lung cancer patients. Here we demonstrate that murine tumor propagating cells (TPCs) with the markers Sca1 and…”
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Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors by De Raedt, Thomas, Walton, Zandra, Yecies, Jessica L., Li, Danan, Chen, Yimei, Malone, Clare F., Maertens, Ophélia, Jeong, Seung Min, Bronson, Roderick T., Lebleu, Valerie, Kalluri, Raghu, Normant, Emmanuel, Haigis, Marcia C., Manning, Brendan D., Wong, Kwok-Kin, Macleod, Kay F., Cichowski, Karen

“…Ras-driven tumors are often refractory to conventional therapies. Here we identify a promising targeted therapeutic strategy for two Ras-driven cancers:…”
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Prospective association between major depressive disorder and leukocyte telomere length over two years by Vance, Mary C., Bui, Eric, Hoeppner, Susanne S., Kovachy, Benjamin, Prescott, Jennifer, Mischoulon, David, Walton, Zandra E., Dong, Melissa, Nadal, Mireya F., Worthington, John J., Hoge, Elizabeth A., Cassano, Paolo, Orr, Esther H., Fava, Maurizio, de Vivo, Immaculata, Wong, Kwok-Kin, Simon, Naomi M.

“…•A baseline diagnosis of MDD prospectively predicted LTL shortening over two years.•Hierarchical regression analyses found this MDD-telomere effect versus…”
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Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors by Carretero, Julian, Shimamura, Takeshi, Rikova, Klarisa, Jackson, Autumn L., Wilkerson, Matthew D., Borgman, Christa L., Buttarazzi, Matthew S., Sanofsky, Benjamin A., McNamara, Kate L., Brandstetter, Kathleyn A., Walton, Zandra E., Gu, Ting-Lei, Silva, Jeffrey C., Crosby, Katherine, Shapiro, Geoffrey I., Maira, Sauveur-Michel, Ji, Hongbin, Castrillon, Diego H., Kim, Carla F., García-Echeverría, Carlos, Bardeesy, Nabeel, Sharpless, Norman E., Hayes, Neil D., Kim, William Y., Engelman, Jeffrey A., Wong, Kwok-Kin

“…In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these…”
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Characterization of the cell of origin for small cell lung cancer by Park, Kwon-Sik, Liang, Mei-Chih, Raiser, David M., Zamponi, Raffaella, Roach, Rebecca R., Curtis, Stephen J., Walton, Zandra, Schaffer, Bethany E., Roake, Caitlin M., Zmoos, Anne-Flore, Kriegel, Christina, Wong, Kwok-Kin, Sage, Julien, Kim, Carla F.

“…Small cell lung carcinoma (SCLC) is a neuroendocrine subtype of lung cancer that affects more than 200,000 people worldwide every year with a very high…”
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Telomere length and telomerase in a well-characterized sample of individuals with major depressive disorder compared to controls by Simon, Naomi M, Walton, Zandra E, Bui, Eric, Prescott, Jennifer, Hoge, Elizabeth, Keshaviah, Aparna, Schwarz, Noah, Dryman, Taylor, Ojserkis, Rebecca A, Kovachy, Benjamin, Mischoulon, David, Worthington, John, DeVivo, Immaculata, Fava, Maurizio, Wong, Kwok-Kin

“…Highlights • Leukocyte telomere length (LTL) was not associated with depression. • Telomerase activity was higher in men with depression even after adjustment…”
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Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers by HATA, Aaron N, YEO, Alan, MINO-KENUDSON, Mari, WONG, Kwok-Kin, ENGELMAN, Jeffrey A, FABER, Anthony C, LIFSHITS, Eugene, ZHAO CHEN, CHENG, Katherine A, WALTON, Zandra, SAROSIEK, Kristopher A, LETAI, Anthony, HEIST, Rebecca S

“…Although several groups have demonstrated that concomitant use of MEK and phosphoinositide 3-kinase (PI3K) inhibitors (MEKi/PI3Ki) can induce dramatic tumor…”
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Abstract 2669: Glutaminase alternative splicing controls tumor growth and metabolism by Stine, Zachary, Walton, Zandra E., Zhang, Lin, Fan, Teresa MW, Lane, Andrew N., Dang, Chi V.

“…Abstract Cancer cells reprogram their metabolism to meet their energetic and biosynthetic needs, with many cancer cells showing increased aerobic glycolysis…”
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