Search Results - "WALSH, T"

Enzymatic Cascade Reactions in Biosynthesis by Walsh, Christopher T., Moore, Bradley S.

“…Enzyme‐mediated cascade reactions are widespread in biosynthesis. To facilitate comparison with the mechanistic categorizations of cascade reactions by…”
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The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury by Gadani, Sachin P., Walsh, James T., Smirnov, Igor, Zheng, Jingjing, Kipnis, Jonathan

“…Inflammation is a prominent feature of CNS injury that heavily influences neuronal survival, yet the signals that initiate and control it remain poorly…”
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Antibiotics for Emerging Pathogens by Fischbach, Michael A., Walsh, Christopher T.

“…Antibiotic-resistant strains of pathogenic bacteria are increasingly prevalent in hospitals and the community. New antibiotics are needed to combat these…”
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Oxidative Cyclization in Natural Product Biosynthesis by Tang, Man-Cheng, Zou, Yi, Watanabe, Kenji, Walsh, Christopher T., Tang, Yi

“…Oxidative cyclizations are important transformations that occur widely during natural product biosynthesis. The transformations from acyclic precursors to…”
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Dealing with Danger in the CNS: The Response of the Immune System to Injury by Gadani, Sachin P., Walsh, James T., Lukens, John R., Kipnis, Jonathan

“…Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both of these functions are upheld by the immune system, though the…”
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A chemocentric view of the natural product inventory by Walsh, Christopher T

“…As the identification of previously undetected microbial biosynthetic pathways burgeons, there arises the question of how much new chemistry is yet to be…”
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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C19 and Voriconazole Therapy by Moriyama, B, Obeng, A Owusu, Barbarino, J, Penzak, SR, Henning, SA, Scott, SA, Agúndez, JAG, Wingard, JR, McLeod, HL, Klein, TE, Cross, SJ, Caudle, KE, Walsh, TJ

“…Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum concentrations, due in part to variant CYP2C19 alleles…”
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Natural Products Version 2.0: Connecting Genes to Molecules by Walsh, Christopher T, Fischbach, Michael A

“…Natural products have played a prominent role in the history of organic chemistry, and they continue to be important as drugs, biological probes, and targets…”
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Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria by Balskus, Emily P, Walsh, Christopher T

“…Ultraviolet UV-A and UV-B radiation is harmful to living systems, causing damage to biological macromolecules. An important strategy for dealing with UV…”
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Sphingolipids and Lipoproteins in Health and Metabolic Disorders by Iqbal, Jahangir, Walsh, Meghan T, Hammad, Samar M, Hussain, M. Mahmood

“…Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and…”
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The emergence of the IL‐36 cytokine family as novel targets for inflammatory diseases by Walsh, Patrick T., Fallon, Padraic G.

“…The recently discovered interleukin (IL)‐36 family of cytokines form part of the broader IL‐1 family and are emerging as important mediators of inflammatory…”
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The Chemical Versatility of Natural-Product Assembly Lines by Walsh, Christopher T

“…Microbial natural products of both polyketide and nonribosomal peptide origin have been and continue to be important therapeutic agents as antibiotics,…”
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Polyketide and Nonribosomal Peptide Antibiotics: Modularity and Versatility by Walsh, Christopher T.

“…Polyketide (PK) and nonribosomal peptides (NRP), constructed on multimodular enzymatic assembly lines, often attain the conformations that establish biological…”
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Prospects for new antibiotics: a molecule-centered perspective by Walsh, Christopher T, Wencewicz, Timothy A

“…There is a continuous need for iterative cycles of antibiotic discovery and development to deal with the selection of resistant pathogens that emerge as…”
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Nonproteinogenic Amino Acid Building Blocks for Nonribosomal Peptide and Hybrid Polyketide Scaffolds by Walsh, Christopher T., O'Brien, Robert V., Khosla, Chaitan

“…Freestanding nonproteinogenic amino acids have long been recognized for their antimetabolite properties and tendency to be uncovered to reactive…”
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Unequal effects of the COVID-19 pandemic on scientists by Myers, Kyle R., Tham, Wei Yang, Yin, Yian, Cohodes, Nina, Thursby, Jerry G., Thursby, Marie C., Schiffer, Peter, Walsh, Joseph T., Lakhani, Karim R., Wang, Dashun

“…COVID-19 has not affected all scientists equally. A survey of principal investigators indicates that female scientists, those in the ‘bench sciences’ and,…”
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Longitudinal Study of Caries Development from Childhood to Adolescence by Hall-Scullin, E., Whitehead, H., Milsom, K., Tickle, M., Su, T.-L., Walsh, T.

“…The World Health Organization (WHO) stated that globally, dental caries is the most important oral condition. To develop effective prevention strategies…”
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Prospects for Antibacterial Discovery and Development by Privalsky, Thomas M, Soohoo, Alexander M, Wang, Jinhua, Walsh, Christopher T, Wright, Gerard D, Gordon, Eric M, Gray, Nathanael S, Khosla, Chaitan

“…The rising prevalence of multidrug-resistant bacteria is an urgent health crisis that can only be countered through renewed investment in the discovery and…”
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Laboratory diagnosis of invasive aspergillosis by Hope, W W, Walsh, T J, Denning, D W

“…Invasive aspergillosis occurs in a wide range of clinical scenarios, is protean in its manifestations, and is still associated with an unacceptably high…”
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Practical atomistic models of carbon fiber surfaces with tuneable topology and topography by Vuković, F., Walsh, T.R.

“…The atomic-scale surface structure of carbon fiber is not well resolved. This information would advance knowledge of structure-property relationships for…”
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