Search Results - "WALLEY, A. J"

Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling by Zeller, C, Dai, W, Steele, N L, Siddiq, A, Walley, A J, Wilhelm-Benartzi, C S M, Rizzo, S, van der Zee, A, Plumb, J A, Brown, R

“…Multiple DNA methylation changes in the cancer methylome are associated with the acquisition of drug resistance; however it remains uncertain how many…”
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Differential coexpression analysis of obesity-associated networks in human subcutaneous adipose tissue by Walley, A J, Jacobson, P, Falchi, M, Bottolo, L, Andersson, J C, Petretto, E, Bonnefond, A, Vaillant, E, Lecoeur, C, Vatin, V, Jernas, M, Balding, D, Petteni, M, Park, Y S, Aitman, T, Richardson, S, Sjostrom, L, Carlsson, L M S, Froguel, P

“…Objective: To use a unique obesity-discordant sib-pair study design to combine differential expression analysis, expression quantitative trait loci (eQTLs)…”
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A reasoned approach by Walley, A. J

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Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy by Walley, A J, Cookson, W O

“…The cytokine cluster located on chromosome 5 has been shown by linkage studies to play a role in the genetic determination of circulating immunoglobulin E…”
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Interferon-alpha receptor-1 (IFNAR1) variants are associated with protection against cerebral malaria in The Gambia by AUCAN, C, WALLEY, A. J, HENNIG, B. J. W, FITNESS, J, FRODSHAM, A, ZHANG, L, KWIATKOWSKI, D, HILL, A. V. S

“…The chromosome 21q22.11 cytokine receptor cluster contains four genes that encode subunits of the receptors for the cytokines interleukin-10 and…”
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Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor by COX, H. E, MOFFATT, M. F, FAUX, J. A, WALLEY, A. J, COLEMAN, R, TREMBATH, R. C, COOKSON, W. O. C. M, HARPER, J. I

“…IgE dysregulation is a major pathogenic feature of atopic dermatitis and other IgE‐mediated allergic diseases such as asthma and rhinitis. Allergen complexed…”
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Linkage and Allelic Association of Chromosome 5 Cytokine Cluster Genetic Markers with Atopy and Asthma Associated Traits by Walley, A.J., Wiltshire, S., Ellis, C.M., Cookson, W.O.C.M.

“…Linkage and association of polymorphic markers in the chromosome 5q31–q33 cytokine cluster to atopy and asthma associated phenotypes have been reported by a…”
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Choice of gDNA isolation method has a significant impact on average murine Telomere Length estimates by Kidd, E., Meimaridou, E., Williams, J., Metherell, L. A., Walley, A. J., Fairbrother, U. L.

“…Telomere Length (TL) and integrity is significantly associated with age-related disease, multiple genetic and environmental factors. We observe mouse genomic…”
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Common apolipoprotein E polymorphisms and risk of clinical malaria in the Gambia by Aucan, C, Walley, A J, Hill, A V S

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Gene polymorphism in Netherton and common atopic disease by Walley, Andrew J, Jones, E. Yvonne, Moffatt, Miriam F, Abecasis, Gonçalo R, Hovnanian, Alain, Wong, Kenny, Esnouf, Robert M, Cookson, William O.C.M, Ubhi, Baljinder, Harper, John I, Chavanas, Stéphane, Lawrence, Robert

“…Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic) responses to common proteins (allergens), many of which are proteinases…”
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Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci by Cookson, William O.C.M, Ubhi, Baljinder, Lawrence, Robert, Abecasis, Gonçalo R, Walley, Andrew J, Cox, Helen E, Coleman, Rosemary, Leaves, Nicholas I, Trembath, Richard C, Moffatt, Miriam F, Harper, John I

“…We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond…”
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Gaucher's disease in the United Kingdom: screening non-Jewish patients for the two common mutations by Walley, A J, Barth, M L, Ellis, I, Fensom, A H, Harris, A

“…Twenty-six patients with Gaucher's disease diagnosed in the United Kingdom and two obligate carriers, all of non-Jewish origin, were screened for the two…”
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A novel point mutation (D380A) and a rare deletion (1255del55) in the glucocerebrosidase gene causing Gaucher's disease by Walley, A J, Harris, A

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Integration of clinical data with a genome‐scale metabolic model of the human adipocyte by Mardinoglu, Adil, Agren, Rasmus, Kampf, Caroline, Asplund, Anna, Nookaew, Intawat, Jacobson, Peter, Walley, Andrew J, Froguel, Philippe, Carlsson, Lena M, Uhlen, Mathias, Nielsen, Jens

“…We evaluated the presence/absence of proteins encoded by 14 077 genes in adipocytes obtained from different tissue samples using immunohistochemistry. By…”
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Delta 32 deletion of CCR5 gene and association with asthma or atopy by Mitchell, Tracey J, Walley, Andrew J, Pease, James E, Venables, Patrick JW, Wiltshire, Steven, Williams, Timothy J, Cookson, William OCM

“…The CCR5-Δ32 deletion polymorphism (CCR5-Δ32) was investigated for linkage and association to asthma and atopy using two panels of nuclear families containing…”
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Direct RNA binding by the rev product of HIV-1 by Walley, A J, Heaphy, S, Jones, I M

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Adipose Tissue Resting Energy Expenditure and Expression of Genes Involved in Mitochondrial Function Are Higher in Women than in Men by Nookaew, Intawat, Svensson, Per-Arne, Jacobson, Peter, Jernås, Margareta, Taube, Magdalena, Larsson, Ingrid, Andersson-Assarsson, Johanna C, Sjöström, Lars, Froguel, Philippe, Walley, Andrew, Nielsen, Jens, Carlsson, Lena M. S

“…Context: Men and women differ in body fat distribution and adipose tissue metabolism as well as in obesity comorbidities and their response to obesity…”
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Three unrelated Gaucher's disease patients with three novel point mutations in the glucocerebrosidase gene (P266R, D315H and A318D) by Walley, A J, Ellis, I, Harris, A

“…Three novel point mutations were detected in the glucocerebrosidase gene of three unrelated Gaucher's disease patients by direct sequencing of PCR products…”
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Leptin Receptor Genotype at Gln223Arg is Associated With Body Composition, BMD, and Vertebral Fracture in Postmenopausal Danish Women by Fairbrother, Una L, Tankó, László B, Walley, Andrew J, Christiansen, Claus, Froguel, Philippe, Blakemore, Alexandra IF

“…Leptin is emerging as a key regulator of bone remodeling. In a population‐based study of 1306 postmenopausal Danish women, nonsynonymous LEPR SNPs were…”
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The genetics of human obesity by Froguel, Philippe, Bell, Christopher G, Walley, Andrew J

“…Obesity is an important cause of morbidity and mortality in developed countries, and is also becoming increasingly prevalent in the developing world. Although…”
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