Search Results - "WALLACE, DARREN P"

PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression by Lakhia, Ronak, Ramalingam, Harini, Chang, Chun-Mien, Cobo-Stark, Patricia, Biggers, Laurence, Flaten, Andrea, Alvarez, Jesus, Valencia, Tania, Wallace, Darren P., Lee, Edmund C., Patel, Vishal

“…Autosomal dominant polycystic kidney disease (ADPKD), among the most common human genetic conditions and a frequent etiology of kidney failure, is primarily…”
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Retinoic acid signaling pathways in development and diseases by Das, Bhaskar C., Thapa, Pritam, Karki, Radha, Das, Sasmita, Mahapatra, Sweta, Liu, Ting-Chun, Torregroza, Ingrid, Wallace, Darren P., Kambhampati, Suman, Van Veldhuizen, Peter, Verma, Amit, Ray, Swapan K., Evans, Todd

“…This graphical abstract represents the chemical structures of retinoic acid and several synthetic derivative retinoids, the use of these chemicals for probing…”
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microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism by Hajarnis, Sachin, Lakhia, Ronak, Yheskel, Matanel, Williams, Darren, Sorourian, Mehran, Liu, Xueqing, Aboudehen, Karam, Zhang, Shanrong, Kersjes, Kara, Galasso, Ryan, Li, Jian, Kaimal, Vivek, Lockton, Steven, Davis, Scott, Flaten, Andrea, Johnson, Joshua A., Holland, William L., Kusminski, Christine M., Scherer, Philipp E., Harris, Peter C., Trudel, Marie, Wallace, Darren P., Igarashi, Peter, Lee, Edmund C., Androsavich, John R., Patel, Vishal

“…Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of renal failure. Here we identify miR-17 as a target for the treatment…”
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Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease by Chen, Li, Zhou, Xia, Fan, Lucy X, Yao, Ying, Swenson-Fields, Katherine I, Gadjeva, Mihaela, Wallace, Darren P, Peters, Dorien J M, Yu, Alan, Grantham, Jared J, Li, Xiaogang

“…Autosomal dominant polycystic kidney disease (ADPKD) is characterized by renal cyst formation, inflammation, and fibrosis. Macrophages infiltrate cystic…”
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Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2-Dependent Mechanism in Polycystic Kidney Disease by Dwivedi, Nidhi, Tao, Shixin, Jamadar, Abeda, Sinha, Sonali, Howard, Christianna, Wallace, Darren P, Fields, Timothy A, Leask, Andrew, Calvet, James P, Rao, Reena

“…Fibrosis is a major cause of loss of renal function in autosomal dominant polycystic kidney disease (ADPKD). In this study, we examined whether vasopressin…”
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MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease by Lakhia, Ronak, Hajarnis, Sachin, Williams, Darren, Aboudehen, Karam, Yheskel, Matanel, Xing, Chao, Hatley, Mark E, Torres, Vicente E, Wallace, Darren P, Patel, Vishal

“…Autosomal dominant polycystic kidney disease (ADPKD), one of the most common monogenetic disorders, is characterized by kidney failure caused by bilateral…”
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Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin by Reif, Gail A, Yamaguchi, Tamio, Nivens, Emily, Fujiki, Hiroyuki, Pinto, Cibele S, Wallace, Darren P

“…In autosomal dominant polycystic kidney disease (ADPKD), arginine vasopressin (AVP) accelerates cyst growth by stimulating cAMP-dependent ERK activity and…”
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The tyrosine-kinase inhibitor Nintedanib ameliorates autosomal-dominant polycystic kidney disease by Jamadar, Abeda, Suma, Sreenath M., Mathew, Sijo, Fields, Timothy A., Wallace, Darren P., Calvet, James P., Rao, Reena

“…Autosomal-dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and is characterized by progressive growth of fluid-filled…”
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Aberrant Regulation of Notch3 Signaling Pathway in Polycystic Kidney Disease by Idowu, Jessica, Home, Trisha, Patel, Nisha, Magenheimer, Brenda, Tran, Pamela V., Maser, Robin L., Ward, Christopher J., Calvet, James P., Wallace, Darren P., Sharma, Madhulika

“…Polycystic kidney disease (PKD) is a genetic disorder characterized by fluid-filled cysts in the kidney and liver that ultimately leads to end-stage renal…”
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Increased water intake decreases progression of polycystic kidney disease in the PCK rat by NAGAO, Shizuko, NISHII, Kazuhiro, KATSUYAMA, Makoto, KURAHASHI, Hiroki, MARUNOUCHI, Tohru, TAKAHASHI, Hisahide, WALLACE, Darren P

“…Renal enlargement in polycystic kidney disease (PKD) is caused by the proliferation of mural epithelial cells and transepithelial fluid secretion into the…”
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Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells by YAMAGUCHI, Tamio, HEMPSON, Scott J, REIF, Gail A, HEDGE, Anne-Marie, WALLACE, Darren P

“…Polycystic kidney disease (PKD) is a lethal disorder characterized by progressive expansion of renal cysts. Genetic mutations associated with PKD are thought…”
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Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease by Pinto, Cibele S, Raman, Archana, Reif, Gail A, Magenheimer, Brenda S, White, Corey, Calvet, James P, Wallace, Darren P

“…cAMP stimulates cell proliferation and Cl(-)-dependent fluid secretion, promoting the progressive enlargement of renal cysts in autosomal dominant polycystic…”
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Author Correction: A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells by Asawa, Rosita R., Danchik, Carina, Zakharov, Alexey, Chen, Yuchi, Voss, Ty, Jadhav, Ajit, Wallace, Darren P., Trott, Josephine F., Weiss, Robert H., Simeonov, Anton, Martinez, Natalia J.

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Periostin promotes renal cyst growth and interstitial fibrosis in polycystic kidney disease by Wallace, Darren P, White, Corey, Savinkova, Lyudmyla, Nivens, Emily, Reif, Gail A, Pinto, Cibele S, Raman, Archana, Parnell, Stephen C, Conway, Simon J, Fields, Timothy A

“…In renal cystic diseases, sustained enlargement of fluid-filled cysts is associated with severe interstitial fibrosis and progressive loss of functioning…”
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Tubular Obstruction Leads to Progressive Proximal Tubular Injury and Atubular Glomeruli in Polycystic Kidney Disease by Galarreta, Carolina I, Grantham, Jared J, Forbes, Michael S, Maser, Robin L, Wallace, Darren P, Chevalier, Robert L

“…In polycystic kidney disease (PKD), renal parenchyma is destroyed by cysts, hypothesized to obstruct nephrons. A signature of unilateral ureteral obstruction,…”
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Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells by Yamaguchi, Tamio, Reif, Gail A, Calvet, James P, Wallace, Darren P

“…In autosomal dominant polycystic kidney disease (ADPKD), aberrant proliferation of the renal epithelial cells is responsible for the formation of numerable…”
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Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells by Venugopal, Jessica, McDermott, Jeffrey, Sanchez, Gladis, Sharma, Madhulika, Barbosa, Leandro, Reif, Gail A., Wallace, Darren P., Blanco, Gustavo

“…The hormone ouabain has been shown to enhance the cystic phenotype of autosomal dominant polycystic kidney disease (ADPKD). Among other characteristics, the…”
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Calcium Restriction Allows cAMP Activation of the B-Raf/ERK Pathway, Switching Cells to a cAMP-dependent Growth-stimulated Phenotype by Yamaguchi, Tamio, Wallace, Darren P., Magenheimer, Brenda S., Hempson, Scott J., Grantham, Jared J., Calvet, James P.

“…cAMP can be either mitogenic or anti-mitogenic, depending on the cell type. We demonstrated previously that cAMP inhibited the proliferation of normal renal…”
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Prospects for mTOR Inhibitor Use in Patients with Polycystic Kidney Disease and Hamartomatous Diseases by Torres, Vicente E, Boletta, Alessandra, Chapman, Arlene, Gattone, Vincent, Pei, York, Qian, Qi, Wallace, Darren P, Weimbs, Thomas, Wüthrich, Rudolf P

“…Mammalian target of rapamycin (mTOR) is the core component of two complexes, mTORC1 and mTORC2. mTORC1 is inhibited by rapamycin and analogues. mTORC2 is…”
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Osteopontin deletion attenuates cyst growth but exacerbates fibrosis in mice with cystic kidney disease by Jansson, Kyle P., Kuluva, Jordan, Zhang, Shiqin, Swanson, Taylor, Zhang, Yan, Zimmerman, Kurt A., Fields, Timothy A., Wallace, Darren P., Rowe, Peter S., Stubbs, Jason R.

“…Osteopontin (OPN) is a multi‐functional glycoprotein that coordinates the innate immune response, prevents nanocrystal formation in renal tubule fluid, and is…”
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