Search Results - "WALL, Brian A"

Functional effects of GRM1 suppression in human melanoma cells by Wangari-Talbot, Janet, Wall, Brian A, Goydos, James S, Chen, Suzie

“…Ectopic expression of a neuronal receptor, metabotropic glutamate receptor 1 (Grm1), in melanocytes has been implicated in melanoma development in mouse…”
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Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma by NAMKOONG, Jin, SHIN, Seung-Shick, HWA JIN LEE, MARIN, Yari E, WALL, Brian A, GOYDOS, James S, CHEN, Suzie

“…Recently, several laboratories have started to investigate the involvement of glutamate signaling in cancer. In previous studies, we reported on a transgenic…”
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Glutamatergic Pathway Targeting in Melanoma: Single-Agent and Combinatorial Therapies by HWA JIN LEE, WALL, Brian A, WANGARI-TALBOT, Janet, SHIN, Seung-Shick, ROSENBERG, Stephen, CHAN, Joseph L-K, NAMKOONG, Jin, GOYDOS, James S, CHEN, Suzie

“…Melanoma is a heterogeneous disease where monotherapies are likely to fail due to variations in genomic signatures. B-RAF inhibitors have been clinically…”
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Riluzole is a radio-sensitizing agent in an in vivo model of brain metastasis derived from GRM1 expressing human melanoma cells by Wall, Brian A., Yu, Lumeng J., Khan, Atif, Haffty, Bruce, Goydos, James S., Chen, Suzie

“…Summary Approximately 50% of patients having metastatic melanoma develop brain metastases during the course of their illness. Evidence exists that melanoma…”
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Oncogenic activities of metabotropic glutamate receptor 1 (Grm1) in melanocyte transformation by Shin, Seung-Shick, Namkoong, Jin, Wall, Brian A., Gleason, Ryan, Lee, Hwa Jin, Chen, Suzie

“…Summary Previously, we reported a transgenic mouse line, TG‐3, that develops spontaneous melanoma with 100% penetrance. We demonstrated that ectopic expression…”
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Riluzole prodrugs for melanoma and ALS: Design, synthesis, and in vitro metabolic profiling by McDonnell, Mark E., Vera, Matthew D., Blass, Benjamin E., Pelletier, Jeffrey C., King, Richard C., Fernandez-Metzler, Carmen, Smith, Garry R., Wrobel, Jay, Chen, Suzie, Wall, Brian A., Reitz, Allen B.

“…Riluzole (1) is an approved therapeutic for the treatment of ALS and has also demonstrated anti-melanoma activity in metabotropic glutamate GRM1 positive cell…”
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Metabotropic glutamate receptors in cancer by Yu, Lumeng J., Wall, Brian A., Wangari-Talbot, Janet, Chen, Suzie

“…Metabotropic glutamate receptors (mGluRs) are widely known for their roles in synaptic signaling. However, accumulating evidence suggests roles of mGluRs in…”
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Evaluation of oral and perioral irritation and sensitization potential of a whitening gel and a whitening toothpaste containing potassium monopersulfate by Li, Yiming, Suprono, Montry S, Cheung, Connie, Ross, Daniella U, Wall, Brian A, Dogo-Isonagie, Cajetan, Arambula, Michele, Xin, Xing

“…Two clinical trials were conducted to investigate the oral and perioral irritation and sensitization potential of a tooth whitening leave-on-gel alone and in…”
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Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo by Shin, Seung-Shick, Jeong, Byeong-Seon, Wall, Brian A., Li, Jiadong, Shan, Naing Lin, Wen, Yu, Goydos, James S., Chen, Suzie

“…Our research group demonstrated that riluzole, an inhibitor of glutamatergic signaling reduced melanoma cell proliferation in vitro and tumor progression in…”
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U1 Adaptor Oligonucleotides Targeting BCL2 and GRM1 Suppress Growth of Human Melanoma Xenografts In Vivo by Goraczniak, Rafal, Wall, Brian A, Behlke, Mark A, Lennox, Kim A, Ho, Eric S, Zaphiros, Nikolas H, Jakubowski, Christopher, Patel, Neil R, Zhao, Steven, Magaway, Carlo, Subbie, Stacey A, Jenny Yu, Lumeng, LaCava, Stephanie, Reuhl, Kenneth R, Chen, Suzie, Gunderson, Samuel I

“…U1 Adaptor is a recently discovered oligonucleotide-based gene-silencing technology with a unique mechanism of action that targets nuclear pre-mRNA processing…”
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The current management of brain metastasis in melanoma: a focus on riluzole by Yu, Lumeng J, Wall, Brian A, Chen, Suzie

“…Brain metastasis is a common endpoint in human malignant melanoma, and the prognosis for patients remains poor despite advancements in therapy. Current…”
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Regulation of mGluR1 expression in human melanocytes and melanoma cells by Lee, Hwa Jin, Wall, Brian A., Wangari-Talbot, Janet, Chen, Suzie

“…We demonstrated that ectopic expression of metabotropic glutamate receptor 1 (mGluR1/Grm1) in mouse melanocytes was sufficient to induce melanoma development…”
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Activation of Grm1 expression by mutated BRaf (V600E) in vitro and in vivo by Chen, Ho-Chung, Sierra, Jairo, Yu, Lumeng Jenny, Cerchio, Jr, Robert, Wall, Brian A, Goydos, James, Chen, Suzie

“…Our laboratory previously showed that ectopic expression of Grm1 is sufficient to induce spontaneous melanoma formation with 100% penetrance in transgenic…”
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Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells by Wall, Brian A., Wangari-Talbot, Janet, Shin, Seung S., Schiff, Devora, Sierra, Jairo, Yu, Lumeng J., Khan, Atif, Haffty, Bruce, Goydos, James S., Chen, Suzie

“…Summary Gain of function of the neuronal receptor, metabotropic glutamate receptor 1 (Grm1), was sufficient to induce melanocytic transformation in vitro and…”
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AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1) by Shin, Seung-Shick, Wall, Brian A., Goydos, James S., Chen, Suzie

“…Summary We reported earlier on the oncogenic properties of Grm1 by demonstrating that stable Grm1‐mouse‐melanocytic clones proliferate in the absence of growth…”
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In silico toxicology protocols by Myatt, Glenn J, Ahlberg, Ernst, Akahori, Yumi, Allen, David, Amberg, Alexander, Anger, Lennart T, Aptula, Aynur, Auerbach, Scott, Beilke, Lisa, Bellion, Phillip, Benigni, Romualdo, Bercu, Joel, Booth, Ewan D, Bower, Dave, Brigo, Alessandro, Burden, Natalie, Cammerer, Zoryana, Cronin, Mark T D, Cross, Kevin P, Custer, Laura, Dettwiler, Magdalena, Dobo, Krista, Ford, Kevin A, Fortin, Marie C, Gad-McDonald, Samantha E, Gellatly, Nichola, Gervais, Véronique, Glover, Kyle P, Glowienke, Susanne, Van Gompel, Jacky, Gutsell, Steve, Hardy, Barry, Harvey, James S, Hillegass, Jedd, Honma, Masamitsu, Hsieh, Jui-Hua, Hsu, Chia-Wen, Hughes, Kathy, Johnson, Candice, Jolly, Robert, Jones, David, Kemper, Ray, Kenyon, Michelle O, Kim, Marlene T, Kruhlak, Naomi L, Kulkarni, Sunil A, Kümmerer, Klaus, Leavitt, Penny, Majer, Bernhard, Masten, Scott, Miller, Scott, Moser, Janet, Mumtaz, Moiz, Muster, Wolfgang, Neilson, Louise, Oprea, Tudor I, Patlewicz, Grace, Paulino, Alexandre, Lo Piparo, Elena, Powley, Mark, Quigley, Donald P, Reddy, M Vijayaraj, Richarz, Andrea-Nicole, Ruiz, Patricia, Schilter, Benoit, Serafimova, Rositsa, Simpson, Wendy, Stavitskaya, Lidiya, Stidl, Reinhard, Suarez-Rodriguez, Diana, Szabo, David T, Teasdale, Andrew, Trejo-Martin, Alejandra, Valentin, Jean-Pierre, Vuorinen, Anna, Wall, Brian A, Watts, Pete, White, Angela T, Wichard, Joerg, Witt, Kristine L, Woolley, Adam, Woolley, David, Zwickl, Craig, Hasselgren, Catrin

“…The present publication surveys several applications of in silico (i.e., computational) toxicology approaches across different industries and institutions. It…”
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Genetic toxicology in silico protocol by Hasselgren, Catrin, Ahlberg, Ernst, Akahori, Yumi, Amberg, Alexander, Anger, Lennart T, Atienzar, Franck, Auerbach, Scott, Beilke, Lisa, Bellion, Phillip, Benigni, Romualdo, Bercu, Joel, Booth, Ewan D, Bower, Dave, Brigo, Alessandro, Cammerer, Zoryana, Cronin, Mark T D, Crooks, Ian, Cross, Kevin P, Custer, Laura, Dobo, Krista, Doktorova, Tatyana, Faulkner, David, Ford, Kevin A, Fortin, Marie C, Frericks, Markus, Gad-McDonald, Samantha E, Gellatly, Nichola, Gerets, Helga, Gervais, Véronique, Glowienke, Susanne, Van Gompel, Jacky, Harvey, James S, Hillegass, Jedd, Honma, Masamitsu, Hsieh, Jui-Hua, Hsu, Chia-Wen, Barton-Maclaren, Tara S, Johnson, Candice, Jolly, Robert, Jones, David, Kemper, Ray, Kenyon, Michelle O, Kruhlak, Naomi L, Kulkarni, Sunil A, Kümmerer, Klaus, Leavitt, Penny, Masten, Scott, Miller, Scott, Moudgal, Chandrika, Muster, Wolfgang, Paulino, Alexandre, Lo Piparo, Elena, Powley, Mark, Quigley, Donald P, Reddy, M Vijayaray, Richarz, Andrea-Nicole, Schilter, Benoit, Snyder, Ronald D, Stavitskaya, Lidiya, Stidl, Reinhard, Szabo, David T, Teasdale, Andrew, Tice, Raymond R, Trejo-Martin, Alejandra, Vuorinen, Anna, Wall, Brian A, Watts, Pete, White, Angela T, Wichard, Joerg, Witt, Kristine L, Woolley, Adam, Woolley, David, Zwickl, Craig, Myatt, Glenn J

“…In silico toxicology (IST) approaches to rapidly assess chemical hazard, and usage of such methods is increasing in all applications but especially for…”
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Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells by Martino, J J, Wall, B A, Mastrantoni, E, Wilimczyk, B J, La Cava, S N, Degenhardt, K, White, E, Chen, S

“…Non-neuronal expression of components of the glutamatergic system has been increasingly observed, and our laboratory previously had demonstrated the…”
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Riluzole is a radio‐sensitizing agent in an in vivo model of brain metastasis derived from GRM 1 expressing human melanoma cells by Wall, Brian A., Yu, Lumeng J., Khan, Atif, Haffty, Bruce, Goydos, James S., Chen, Suzie

“…Summary Approximately 50% of patients having metastatic melanoma develop brain metastases during the course of their illness. Evidence exists that melanoma…”
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Curcumin downregulates the constitutive activity of NF-κB and induces apoptosis in novel mouse melanoma cells by Marín, Yarí E., Wall, Brian A., Wang, Su, Namkoong, Jin, Martino, Jeffrey J., Suh, Junghan, Lee, Hwa Jin, Rabson, Arnold B., Yang, Chung S., Chen, Suzie, Ryu, Jae-Ha

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