Search Results - "WALKER, I"

xMSannotator: An R Package for Network-Based Annotation of High-Resolution Metabolomics Data by Uppal, Karan, Walker, Douglas I, Jones, Dean P

“…Improved analytical technologies and data extraction algorithms enable detection of >10 000 reproducible signals by liquid chromatography–high-resolution mass…”
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Identifying Molecules as Biosignatures with Assembly Theory and Mass Spectrometry by Marshall, Stuart M, Mathis, Cole, Carrick, Emma, Keenan, Graham, Cooper, Geoffrey J T, Graham, Heather, Bame, Jessica R, Craven, Matthew, Bell, Nicola L, Gromski, Piotr S, Swart, Marcel, Moore, Douglas G, Walker, Sara I, Cronin, Leroy

“…The search for evidence of life elsewhere in the universe is hard because it is not obvious what signatures are unique to life. Here we postulate that complex…”
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Surgical safety checklists: do they improve outcomes? by Walker, I.A., Reshamwalla, S., Wilson, I.H.

“…The concept of using a checklist in surgical and anaesthetic practice was energized by publication of the WHO Surgical Safety Checklist in 2008. It was…”
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Viral indicators for tracking domestic wastewater contamination in the aquatic environment by Farkas, Kata, Walker, David I., Adriaenssens, Evelien M., McDonald, James E., Hillary, Luke S., Malham, Shelagh K., Jones, Davey L.

“…Waterborne enteric viruses are an emerging cause of disease outbreaks and represent a major threat to global public health. Enteric viruses may originate from…”
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Computational Metabolomics: A Framework for the Million Metabolome by Uppal, Karan, Walker, Douglas I, Liu, Ken, Li, Shuzhao, Go, Young-Mi, Jones, Dean P

“…“Sola dosis facit venenum.” These words of Paracelsus, “the dose makes the poison”, can lead to a cavalier attitude concerning potential toxicities of the vast…”
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Sampling interstitial fluid from human skin using a microneedle patch by Samant, Pradnya P, Niedzwiecki, Megan M, Raviele, Nicholas, Tran, Vilinh, Mena-Lapaix, Juan, Walker, Douglas I, Felner, Eric I, Jones, Dean P, Miller, Gary W, Prausnitz, Mark R

“…Tissue interstitial fluid (ISF) surrounds cells and is an underutilized source of biomarkers that complements conventional sources such as blood and urine…”
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Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis by Costello, Elizabeth, Rock, Sarah, Stratakis, Nikos, Eckel, Sandrah P, Walker, Douglas I, Valvi, Damaskini, Cserbik, Dora, Jenkins, Todd, Xanthakos, Stavra A, Kohli, Rohit, Sisley, Stephanie, Vasiliou, Vasilis, La Merrill, Michele A, Rosen, Hugo, Conti, David V, McConnell, Rob, Chatzi, Leda

“…Experimental evidence indicates that exposure to certain pollutants is associated with liver damage. Per- and polyfluoroalkyl substances (PFAS) are persistent…”
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The Exposome: Molecules to Populations by Niedzwiecki, Megan M, Walker, Douglas I, Vermeulen, Roel, Chadeau-Hyam, Marc, Jones, Dean P, Miller, Gary W

“…Derived from the term exposure, the exposome is an omic-scale characterization of the nongenetic drivers of health and disease. With the genome, it defines the…”
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Reference Standardization for Quantification and Harmonization of Large-Scale Metabolomics by Liu, Ken H, Nellis, Mary, Uppal, Karan, Ma, Chunyu, Tran, ViLinh, Liang, Yongliang, Walker, Douglas I, Jones, Dean P

“…Reference standardization was developed to address quantification and harmonization challenges for high-resolution metabolomics (HRM) data collected across…”
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Perfluoroalkyl substances and severity of nonalcoholic fatty liver in Children: An untargeted metabolomics approach by Jin, Ran, McConnell, Rob, Catherine, Cioffi, Xu, Shujing, Walker, Douglas I., Stratakis, Nikos, Jones, Dean P., Miller, Gary W., Peng, Cheng, Conti, David V., Vos, Miriam B., Chatzi, Leda

“…•PFAS induce hepatotoxic effects in animal models but human evidence is limited.•First study to investigate PFAS exposures and NAFLD severity in…”
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Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3 by Pillai, Vinodkumar B., Samant, Sadhana, Sundaresan, Nagalingam R., Raghuraman, Hariharasundaram, Kim, Gene, Bonner, Michael Y., Arbiser, Jack L., Walker, Douglas I., Jones, Dean P., Gius, David, Gupta, Mahesh P.

“…Honokiol (HKL) is a natural biphenolic compound derived from the bark of magnolia trees with anti-inflammatory, anti-oxidative, anti-tumour and neuroprotective…”
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Thrombophilia in pregnancy: a systematic review by Robertson, L., Wu, O., Langhorne, P., Twaddle, S., Clark, P., Lowe, G. D. O., Walker, I. D., Greaves, M., Brenkel, I., Regan, L., Greer, I. A.

“…Summary Growing evidence suggests that thrombophilia is associated with venous thromboembolism (VTE) and adverse pregnancy outcomes. However, methodological…”
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Status of vaccine research and development for enterotoxigenic Escherichia coli by Bourgeois, A. Louis, Wierzba, Thomas F, Walker, Richard I

“…Highlights • ETEC is a top cause of diarrhea in children and travelers to low-resource countries. • Models suggest ETEC vaccines would be cost-effective and…”
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Your opinion on climate change might not be as common as you think by Leviston, Z., Walker, I., Morwinski, S.

“…Political and media debate on the existence and causes of climate change often rests on claims about what most citizens really think. New research demonstrates…”
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Criticality Distinguishes the Ensemble of Biological Regulatory Networks by Daniels, Bryan C, Kim, Hyunju, Moore, Douglas, Zhou, Siyu, Smith, Harrison B, Karas, Bradley, Kauffman, Stuart A, Walker, Sara I

“…The hypothesis that many living systems should exhibit near-critical behavior is well motivated theoretically, and an increasing number of cases have been…”
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Perfluoroalkyl substances, metabolomic profiling, and alterations in glucose homeostasis among overweight and obese Hispanic children: A proof-of-concept analysis by Alderete, Tanya L., Jin, Ran, Walker, Douglas I., Valvi, Damaskini, Chen, Zhanghua, Jones, Dean P., Peng, Cheng, Gilliland, Frank D., Berhane, Kiros, Conti, David V., Goran, Michael I., Chatzi, Lida

“…To examine the prospective associations between exposure to perfluoroalkyl substances (PFASs) and longitudinal measurements of glucose metabolism in high-risk…”
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ADAP-GC 4.0: Application of Clustering-Assisted Multivariate Curve Resolution to Spectral Deconvolution of Gas Chromatography–Mass Spectrometry Metabolomics Data by Smirnov, Aleksandr, Qiu, Yunping, Jia, Wei, Walker, Douglas I, Jones, Dean P, Du, Xiuxia

“…We report a multivariate curve resolution (MCR)-based spectral deconvolution workflow for untargeted gas chromatography–mass spectrometry metabolomics. As an…”
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Prediction of hematocrit decline and the impact of peri-operative fluid use in lumbar spinal fusion surgery by Walker, I. S., Vlok, A. J., Esterhuizen, T. M., van der Horst, A.

“…Purpose Peri-operative blood loss unaccounted for and post-operative hematocrit decline could have a significant impact on the outcome of elective spinal…”
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Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults by Chen, Zhanghua, Yang, Tingyu, Walker, Douglas I., Thomas, Duncan C., Qiu, Chenyu, Chatzi, Leda, Alderete, Tanya L., Kim, Jeniffer S., Conti, David V., Breton, Carrie V., Liang, Donghai, Hauser, Elizabeth R., Jones, Dean P., Gilliland, Frank D.

“…•Per- and polyfluoroalkyl substances (PFASs) are associated with glucose intolerance.•PFAS is associated with increased lipolysis.•Lipid metabolism may…”
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An analysis of 45 large-scale wastewater sites in England to estimate SARS-CoV-2 community prevalence by Morvan, Mario, Jacomo, Anna Lo, Souque, Celia, Wade, Matthew J., Hoffmann, Till, Pouwels, Koen, Lilley, Chris, Singer, Andrew C., Porter, Jonathan, Evens, Nicholas P., Walker, David I., Bunce, Joshua T., Engeli, Andrew, Grimsley, Jasmine, O’Reilly, Kathleen M., Danon, Leon

“…Accurate surveillance of the COVID-19 pandemic can be weakened by under-reporting of cases, particularly due to asymptomatic or pre-symptomatic infections,…”
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