Search Results - "WALI, Aminah"
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The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation
Published in Molecular cell (30-11-2012)“…Widespread changes in gene expression drive tumorigenesis, yet our knowledge of how aberrant epigenomic and transcriptome profiles arise in cancer cells is…”
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Microbial regulation of glucose metabolism and cell-cycle progression in mammalian colonocytes
Published in PloS one (28-09-2012)“…A prodigious number of microbes inhabit the human body, especially in the lumen of the gastrointestinal (GI) tract, yet our knowledge of how they regulate…”
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3
High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility
Published in Proceedings of the National Academy of Sciences - PNAS (15-03-2016)“…Mutations in chromatin-modifying proteins and transcription factors are commonly associated with a wide variety of cancers. Through gain- or loss-of-function,…”
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MS0621, a novel small-molecule modulator of Ewing sarcoma chromatin accessibility, interacts with an RNA-associated macromolecular complex and influences RNA splicing
Published in Frontiers in oncology (30-01-2023)“…Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1…”
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An Eye on Trafficking Genes: Identification of Four Eye Color Mutations in Drosophila
Published in G3 : genes - genomes - genetics (01-10-2016)“…Genes that code for proteins involved in organelle biogenesis and intracellular trafficking produce products that are critical in normal cell function …”
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Advancing NGS quality control to enable measurement of actionable mutations in circulating tumor DNA
Published in Cell reports methods (22-11-2021)“…The primary objective of the FDA-led Sequencing and Quality Control Phase 2 (SEQC2) project is to develop standard analysis protocols and quality control…”
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Biological Characterization of Chromatin-Targeted Small Molecules
Published 01-01-2017“…Chromatin regulation is commonly disrupted in human cancers. The identification of chemical probes that reverse chromatin defects can provide mechanistic…”
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Dissertation -
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A Hoxb13-driven reverse tetracycline transactivator system for conditional gene expression in the prostate
Published in The Prostate (01-07-2012)“…BACKGROUND Genetically engineered mouse models play important roles in analyses of prostate development and pathobiology. While constitutive genetic gain‐ and…”
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A Hoxbl3-Driven ReverseTetracyclineTransactivator System for Conditional Gene Expression in the Prostate
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Journal Article