Search Results - "WALDMEIER, Felix"

METABOLISM AND DISPOSITION OF IMATINIB MESYLATE IN HEALTHY VOLUNTEERS by GSCHWIND, Hans-Peter, PFAAR, Ulrike, BIN PENG, GROSS, Gerhard, WALDMEIER, Felix, ZOLLINGER, Markus, SAYER, Claudia, ZBINDEN, Peter, HAYES, Michael, POKORNY, Rolf, SEIBERLING, Michael, BEN-AM, Monique

“…Imatinib mesylate (GLEEVEC, GLIVEC, formerly STI571) has demonstrated unprecedented efficacy as first-line therapy for treatment for all phases of chronic…”
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Absorption, Distribution, Metabolism, and Elimination of the Direct Renin Inhibitor Aliskiren in Healthy Volunteers by WALDMEIER, Felix, GLAENZEL, Ulrike, WIRZ, Bernard, OBERER, Lukas, SCHMID, Dietmar, SEIBERLING, Michael, VALENCIA, Jessica, RIVIERE, Gilles-Jacques, END, Peter, VAIDYANATHAN, Sujata

“…Aliskiren (2( S ),4( S ),5( S ),7( S )- N -(2-carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamid…”
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Pharmacokinetics, Distribution, Metabolism, and Excretion of Deferasirox and Its Iron Complex in Rats by BRUIN, Gerard J. M, FALLER, Thomas, WIEGAND, Hansjörg, SCHWEITZER, Alain, NICK, Hanspeter, SCHNEIDER, Josef, BOERNSEN, K.-Olaf, WALDMEIER, Felix

“…Deferasirox (Exjade, ICL670, CGP72670) is an iron-chelating drug for p.o. treatment of transfusional iron overload in patients with β-thalassemia or sickle…”
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Metabolism and Disposition of Vatalanib (PTK787/ZK-222584) in Cancer Patients by JOST, Lorenz M, GSCHWIND, Hans-Peter, MASSON, Eric, LAURENT, Dirk, JALAVA, Tarja, YONGYU WANG, GUENTHER, Clemens, SOUPPART, Claire, ROTTMANN, Antje, DENNER, Karsten, WALDMEIER, Felix, GROSS, Gerhard

“…Vatalanib (PTK787/ZK-222584) is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under…”
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PIMECROLIMUS: ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION IN HEALTHY VOLUNTEERS AFTER A SINGLE ORAL DOSE AND SUPPLEMENTARY INVESTIGATIONS IN VITRO by ZOLLINGER, Markus, WALDMEIER, Felix, GRASSBERGER, Maximilian A, HARTMANN, Stefan, ZENKE, Gerhard, ZIMMERLIN, Alfred G, GLAENZEL, Ulrike, BALDECK, Jean-Pierre, SCHWEITZER, Alain, BERTHIER, Stephane, MOENIUS, Thomas

“…The absorption and disposition of pimecrolimus, a calcineurin inhibitor developed for the treatment of inflammatory skin diseases, was investigated in four…”
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Pharmacokinetics, Metabolism, and Disposition of Deferasirox in β-Thalassemic Patients with Transfusion-Dependent Iron Overload Who Are at Pharmacokinetic Steady State by WALDMEIER, Felix, BRUIN, Gerard J, GLAENZEL, Ulrike, HAZELL, Katharine, SECHAUD, Romain, WARRINGTON, Steve, PORTER, John B

“…Deferasirox (ICL670) is a novel once-daily, orally administered iron chelator to treat chronic iron overload in patients with transfusion-dependent anemias…”
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Safety and Pharmacokinetics of a Single 1500-mg Dose of Famciclovir in Adolescents With Recurrent Herpes Labialis by Block, Stan L, Yogev, Ram, Waldmeier, Felix, Hamed, Kamal

“…An open-label study evaluated the safety (n = 53) and pharmacokinetics (n = 8) of single-dose therapy with 1500 mg famciclovir (prodrug of penciclovir) for…”
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A microplate solid scintillation counter as a radioactivity detector for high performance liquid chromatography in drug metabolism: Validation and applications by Bruin, Gerard J., Waldmeier, Felix, Boernsen, K. Olaf, Pfaar, Ulrike, Gross, Gerhard, Zollinger, Markus

“…Sensitive radioactivity detection following high performance liquid chromatography (HPLC) separation remains a challenge in many drug metabolism studies with…”
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Pimecrolimus: Skin disposition after topical administration in minipigs in vivo and in human skin in vitro by Gschwind, Hans-Peter, Waldmeier, Felix, Zollinger, Markus, Schweitzer, Alain, Grassberger, Maximilian

“…The dermal disposition of pimecrolimus, a non-steroid, anti-inflammatory calcineurin inhibitor used for the treatment of atopic dermatitis, was evaluated in…”
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Metabolism of patupilone in patients with advanced solid tumor malignancies by Kelly, Kevin R., Zollinger, Markus, Lozac’h, Frédéric, Tan, Eugene, Mita, Alain, Waldmeier, Felix, Urban, Patrick, Anand, Suraj, Wang, Yanfeng, Swart, Piet, Takimoto, Chris, Mita, Monica

“…Summary A phase 1, open-label, non-randomized, single center study was conducted to determine the pharmacokinetics, distribution, metabolism, elimination, and…”
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The Pharmacokinetics and Pharmacodynamics of Zoledronic Acid in Cancer Patients with Varying Degrees of Renal Function by Skerjanec, Andrej, Berenson, James, Hsu, ChyiHung, Major, Pierre, Miller Jr, Wilson H., Ravera, Christina, Schran, Horst, Seaman, John, Waldmeier, Felix

“…An open‐label pharmacokinetic and pharmacodynamic study of zoledronic acid (Zometaθ) was performed in 19 cancer patients with bone metastases and known,…”
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Metabolism and disposition of the oral absorption enhancer 14C-radiolabeled 8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC) in healthy postmenopausal women and supplementary investigations in vitro by Gschwind, Hans-Peter, Glaenzel, Ulrike, Waldmeier, Felix, Wirz, Bernard, Sabia, Helene D., Picard, Franck, Markus Weiss, H., Choi, Leslie, Swart, Pieter Jacob, Vasudevan, Ajithkumar, Azria, Moïse

“…8-(N-2-hydroxy-5-chlorobenzoyl)-amino-caprylic acid (5-CNAC), a compound lacking pharmacological activity enhances the absorption of salmon calcitonin, when…”
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Percutaneous absorption of pimecrolimus is not increased in patients with moderate to severe atopic dermatitis when pimecrolimus cream 1% is applied under occlusion by Thaçi, Diamant, Kaufmann, Roland, Bieber, Thomas, Hanfland, Julia, Hauffe, Suzanne, Koehne-Voss, Stephan, Waldmeier, Felix

“…To evaluate the systemic exposure of pimecrolimus cream 1% applied under occlusion in atopic dermatitis (AD) patients. A noncomparative, open-label study…”
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Pharmacokinetics of valsartan in patients with liver disease by Brookman, Laurence J., Rolan, Paul E., Benjamin, Irving S., Palmer, Kelvin R., Wyld, Peter J., Lloyd, Peter, Flesch, Gérard, Waldmeier, Felix, Sioufi, Antoine, Mullins, Frank

“…Objectives Valsartan (CGP 48933), an orally active angiotensin II antagonist, is eliminated mainly by hepatic clearance. To characterize the compound(s)…”
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Pharmacokinetics and metabolism of formestane in breast cancer patients by Lønning, Per Eystein, Geisler, Jürgen, Johannessen, Dag Clement, Gschwind, Hans-Peter, Waldmeier, Felix, Schneider, Werner, Galli, Bruno, Winkler, Tammo, Blum, Wolfgang, Kriemler, Hans-Peter, Miller, William Russell, Faigle, Johann Werner

“…Formestane (Lentaron®, 4-hydroxyandrostenedione) is a steroidal aromatase inhibitor used for treatment of advanced breast cancer. Clinically, it is…”
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