Search Results - "WALDMANN, Thomas A"

The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design by Waldmann, Thomas A

“…Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death of lymphocytes. Although their heterotrimeric receptors have two…”
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The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy by Waldmann, Thomas A

“…IL2 and IL15, members of the 4α-helix bundle family of cytokines, play pivotal roles in the control of the life and death of lymphocytes. Although their…”
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Interleukin-15 biology and its therapeutic implications in cancer by Steel, Jason C, Waldmann, Thomas A, Morris, John C

“…Cancer immunotherapy is designed to stimulate the immune system to reject and destroy tumors. Recently, interleukin-15 (IL-15), a member of the four α-helix…”
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IL-15 in the Combination Immunotherapy of Cancer by Waldmann, Thomas A, Dubois, Sigrid, Miljkovic, Milos D, Conlon, Kevin C

“…We completed clinical trials of rhIL-15 by bolus, subcutaneous, and continuous intravenous infusions (CIV). IL-15 administered by CIV at 2 mcg/kg/day yielded a…”
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Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear Phagocytes by Yu, Huifeng, Sui, Yongjun, Wang, Yichuan, Sato, Noriko, Frey, Blake, Xia, Zheng, Waldmann, Thomas A, Berzofsky, Jay

“…Interleukin (IL)-15 has multiple roles in innate and adaptive immunity, especially regarding CD8+ T cells and natural killer cells. However, the role of IL-15…”
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Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma by Yang, Yibin, Shaffer, Arthur L., Emre, N.C. Tolga, Ceribelli, Michele, Zhang, Meili, Wright, George, Xiao, Wenming, Powell, John, Platig, John, Kohlhammer, Holger, Young, Ryan M., Zhao, Hong, Yang, Yandan, Xu, Weihong, Buggy, Joseph J., Balasubramanian, Sriram, Mathews, Lesley A., Shinn, Paul, Guha, Rajarshi, Ferrer, Marc, Thomas, Craig, Waldmann, Thomas A., Staudt, Louis M.

“…Knowledge of oncogenic mutations can inspire therapeutic strategies that are synthetically lethal, affecting cancer cells while sparing normal cells…”
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Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps by Mitra, Suman, Ring, Aaron M., Amarnath, Shoba, Spangler, Jamie B., Li, Peng, Ju, Wei, Fischer, Suzanne, Oh, Jangsuk, Spolski, Rosanne, Weiskopf, Kipp, Kohrt, Holbrook, Foley, Jason E., Rajagopalan, Sumati, Long, Eric O., Fowler, Daniel H., Waldmann, Thomas A., Garcia, K. Christopher, Leonard, Warren J.

“…Interleukin-2 (IL-2) regulates lymphocyte function by signaling through heterodimerization of the IL-2Rβ and γc receptor subunits. IL-2 is of considerable…”
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Gene regulation and suppression of type I interferon signaling by STAT3 in diffuse large B cell lymphoma by Lu, Li, Zhu, Fen, Zhang, Meili, Li, Yangguang, Drennan, Amanda C., Kimpara, Shuichi, Rumball, Ian, Selzer, Christopher, Cameron, Hunter, Kellicut, Ashley, Kelm, Amanda, Wang, Fangyu, Waldmann, Thomas A., Rui, Lixin

“…STAT3 is constitutively activated in many cancers and regulates gene expression to promote cancer cell survival, proliferation, invasion, and migration. In…”
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Cytokines in Cancer Immunotherapy by Waldmann, Thomas A

“…Cytokines that control the immune response were shown to have efficacy in preclinical murine cancer models. Interferon (IFN)-α is approved for treatment of…”
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Simultaneous Blockade of Multiple immune System Inhibitory Checkpoints Enhances Antitumor Activity Mediated by Interleukin-15 in a Murine Metastatic Colon Carcinoma Model by PING YU, STEEL, Jason C, MEILI ZHANG, MORRIS, John C, WALDMANN, Thomas A

“…Interleukin 15 (IL-15) is a promising cytokine for immunotherapy of cancer due to its ability to stimulate the immunity of natural killer, B, and T cells. Its…”
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The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use by Perera, Pin-Yu, Lichy, Jack H., Waldmann, Thomas A., Perera, Liyanage P.

“…Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the…”
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Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey by Waldmann, Thomas A

“…Twenty-five years ago, we reported the production of the monoclonal antibody, anti-Tac that identifies the IL-2 receptor alpha subunit and blocks the…”
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First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia by Cooley, Sarah, He, Fiona, Bachanova, Veronika, Vercellotti, Gregory M., DeFor, Todd E., Curtsinger, Julie M., Robertson, Paul, Grzywacz, Bartosz, Conlon, Kevin C., Waldmann, Thomas A., McKenna, David H., Blazar, Bruce R., Weisdorf, Daniel J., Miller, Jeffrey S.

“…In vivo expansion of haploidentical natural killer (NK) cell infusions with interleukin-2 (IL-2) can induce remission of refractory acute myeloid leukemia, but…”
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A20 and RBX1 Regulate Brentuximab Vedotin Sensitivity in Hodgkin Lymphoma Models by Wei, Wei, Lin, Yuquan, Song, Zhihui, Xiao, Wenming, Chen, Liqi, Yin, Jiejing, Zhou, Yan, Barta, Stefan K, Petrus, Michael, Waldmann, Thomas A, Yang, Yibin

“…For patients with refractory/relapsed Hodgkin lymphoma (roughly 20% of total cases), few effective therapeutic options exist. Currently, brentuximab vedotin…”
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Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance by Traba, Javier, Sack, Michael N, Waldmann, Thomas A, Anton, Olga M

“…Constitutive activity of the immune surveillance system detects and kills cancerous cells, although many cancers have developed strategies to avoid detection…”
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Cytokine receptor signaling is required for the survival of ALK− anaplastic large cell lymphoma, even in the presence of JAK1/STAT3 mutations by Chen, Jing, Zhang, Yong, Petrus, Michael N., Xiao, Wenming, Nicolae, Alina, Raffeld, Mark, Pittaluga, Stefania, Bamford, Richard N., Nakagawa, Masao, Ouyang, Sunny Tianyi, Epstein, Alan L., Kadin, Marshall E., Del Mistro, Annarose, Woessner, Richard, Jaffe, Elaine S., Waldmann, Thomas A.

“…Activating Janus kinase (JAK) and signal transducer and activator of transcription (STAT) mutations have been discovered in many T-cell malignancies, including…”
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Interleukin 15 Pharmacokinetics and Consumption by a Dynamic Cytokine Sink by Hangasky, John A, Waldmann, Thomas A, Santi, Daniel V

“…Interleukin-15 (IL-15) is crucial for the proliferation and survival of NK and CD8 T memory cells, and of significant interest in immuno-oncology. Immune cell…”
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Essential role of the linear ubiquitin chain assembly complex and TAK1 kinase in A20 mutant Hodgkin lymphoma by Song, Zhihui, Wei, Wei, Xiao, Wenming, Al-Saleem, Essel D., Nejati, Reza, Chen, Liqi, Yin, Jiejing, Fabrizio, Joseph, Petrus, Michael N., Waldmann, Thomas A., Yang, Yibin

“…More than 70% of Epstein–Barr virus (EBV)-negative Hodgkin lymphoma (HL) cases display inactivation of TNFAIP3 (A20), a ubiquitin-editing protein that…”
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Regulation of normal B-cell differentiation and malignant B-cell survival by OCT2 by Hodson, Daniel J., Shaffer, Arthur L., Xiao, Wenming, Wright, George W., Schmitz, Roland, Phelan, James D., Yang, Yandan, Webster, Daniel E., Rui, Lixin, Kohlhammer, Holger, Nakagawa, Masao, Waldmann, Thomas A., Staudt, Louis M.

“…The requirement for the B-cell transcription factor OCT2 (octamer-binding protein 2, encoded by Pou2f2) in germinal center B cells has proved controversial…”
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Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2–dependent adult T-cell leukemia by Zhang, Meili, Griner, Lesley A. Mathews, Ju, Wei, Duveau, Damien Y., Guha, Rajarshi, Petrus, Michael N., Wen, Bernard, Maeda, Michiyuki, Shinn, Paul, Ferrer, Marc, Conlon, Kevin D., Bamford, Richard N., O’Shea, John J., Thomas, Craig J., Waldmann, Thomas A.

“…Adult T-cell leukemia (ATL) develops in individuals infected with human T-cell lymphotropic virus-1 (HTLV-1). Presently there is no curative therapy for ATL…”
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