Search Results - "WALDEGGER, Siegfried"

Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization by Hou, Jianghui, Renigunta, Aparna, Yang, Jing, Waldegger, Siegfried, Burg, Maurice B.

“…Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. The paracellular pathway in the collecting duct of the kidney…”
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Disease Recurrence-The Sword of Damocles in Kidney Transplantation for Primary Focal Segmental Glomerulosclerosis by Kienzl-Wagner, Katrin, Waldegger, Siegfried, Schneeberger, Stefan

“…A major obstacle in kidney transplantation for primary focal segmental glomerulosclerosis (FSGS) is the risk of disease recurrence. Recurrent FSGS affects up…”
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Twelve-month outcome in juvenile proliferative lupus nephritis: results of the German registry study by Suhlrie, Adriana, Hennies, Imke, Gellermann, Jutta, Büscher, Anja, Hoyer, Peter, Waldegger, Siegfried, Wygoda, Simone, Beetz, Rolf, Lange-Sperandio, Bärbel, Klaus, Günter, Konrad, Martin, Holder, Martin, Staude, Hagen, Rascher, Wolfgang, Oh, Jun, Pape, Lars, Tönshoff, Burkhard, Haffner, Dieter

“…Background Children presenting with proliferative lupus nephritis (LN) are treated with intensified immunosuppressive protocols. Data on renal outcome and…”
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Claudin-16 and claudin-19 interaction is required for their assembly into tight junctions and for renal reabsorption of magnesium by Hou, Jianghui, Renigunta, Aparna, Gomes, Antonio S, Hou, Mingli, Paul, David L, Waldegger, Siegfried, Goodenough, Daniel A

“…Claudins are tight junction integral membrane proteins that are key regulators of the paracellular pathway. Defects in claudin-16 (CLDN16) and CLDN19 function…”
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Claudin-16 and claudin-19 interact and form a cation-selective tight junction complex by Hou, Jianghui, Renigunta, Aparna, Konrad, Martin, Gomes, Antonio S, Schneeberger, Eveline E, Paul, David L, Waldegger, Siegfried, Goodenough, Daniel A

“…Tight junctions (TJs) play a key role in mediating paracellular ion reabsorption in the kidney. Familial hypomagnesemia with hypercalciuria and…”
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TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury by Peters, Dorothea M, Vadász, István, Wujak, Lukasz, Wygrecka, Malgorzata, Olschewski, Andrea, Becker, Christin, Herold, Susanne, Papp, Rita, Mayer, Konstantin, Rummel, Sebastian, Brandes, Ralph P, Günther, Andreas, Waldegger, Siegfried, Eickelberg, Oliver, Seeger, Werner, Morty, Rory E

“…TGF-β is a pathogenic factor in patients with acute respiratory distress syndrome (ARDS), a condition characterized by alveolar edema. A unique TGF-β pathway…”
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Disruption of TRPM6/TRPM7 Complex Formation by a Mutation in the TRPM6 Gene Causes Hypomagnesemia with Secondary Hypocalcemia by Chubanov, Vladimir, Waldegger, Siegfried, Michael Mederos y Schnitzler, Vitzthum, Helga, Sassen, Martin C., Seyberth, Hannsjörg W., Konrad, Martin, Gudermann, Thomas, Jan, Lily Y.

“…Impaired magnesium reabsorption in patients with TRPM6 gene mutations stresses an important role of TRPM6 (melastatin-related TRP cation channel) in epithelial…”
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Functional Significance of Cell Volume Regulatory Mechanisms by LANG, FLORIAN, BUSCH, GILLIAN L, RITTER, MARKUS, VOLKL, HARALD, WALDEGGER, SIEGFRIED, GULBINS, ERICH, HAUSSINGER, DIETER

“…FLORIAN LANG , GILLIAN L. BUSCH , MARKUS RITTER , HARALD VÖLKL , SIEGFRIED WALDEGGER , ERICH GULBINS , AND DIETER HÄUSSINGER Institute of Physiology,…”
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Colocalization of KCNQ1/KCNE channel subunits in the mouse gastrointestinal tract by Dedek, K, Waldegger, S

“…The KCNQI potassium channel alpha-subunit can associate with various KCNE beta-subunits that drastically influence channel gating. Here we show that in the…”
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Hypomagnesemia with Secondary Hypocalcemia due to a Missense Mutation in the Putative Pore-forming Region of TRPM6 by Chubanov, Vladimir, Schlingmann, Karl P., Wäring, Janine, Heinzinger, Jolanta, Kaske, Silke, Waldegger, Siegfried, Schnitzler, Michael Mederos y, Gudermann, Thomas

“…Hypomagnesemia with secondary hypocalcemia is an autosomal recessive disorder caused by mutations in the TRPM6 gene. Current experimental evidence suggests…”
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Intracellular Anions as the Voltage Sensor of Prestin, the Outer Hair Cell Motor Protein by Oliver, Dominik, David Z. Z. He, Klöcker, Nikolaj, Ludwig, Jost, Schulte, Uwe, Waldegger, Siegfried, Ruppersberg, J. P., Dallos, Peter, Fakler, Bernd

“…Outer hair cells (OHCs) of the mammalian cochlea actively change their cell length in response to changes in membrane potential. This electromotility, thought…”
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A constitutively open potassium channel formed by KCNQ1 and KCNE3 by Jentsch, Thomas J, Schroeder, Björn C, Waldegger, Siegfried, Fehr, Susanne, Bleich, Markus, Warth, Richard, Greger, Rainer

“…Mutations in all four known KCNQ potassium channel α-subunit genes lead to human diseases. KCNQ1 (KvLQT1) interacts with the β-subunit KCNE1 (IsK, minK) to…”
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Successful management of recurrent focal segmental glomerulosclerosis by Kienzl-Wagner, Katrin, Rosales, Alejandra, Scheidl, Stefan, Giner, Thomas, Bösmüller, Claudia, Rudnicki, Michael, Oberhuber, Rupert, Margreiter, Christian, Soleiman, Afschin, Öfner, Dietmar, Waldegger, Siegfried, Schneeberger, Stefan

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Cloning and Characterization of a Putative Human Serine/Threonine Protein Kinase Transcriptionally Modified during Anisotonic and Isotonic Alterations of Cell Volume by Waldegger, Siegfried, Barth, Petra, Raber, Gertraud, Lang, Florian

“…Hepatic metabolism and gene expression are among other regulatory mechanisms controlled by the cellular hydration state, which changes rapidly in response to…”
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Salt handling in the distal nephron: lessons learned from inherited human disorders by Jeck, Nikola, Schlingmann, Karl P, Reinalter, Stephan C, Kömhoff, Martin, Peters, Melanie, Waldegger, Siegfried, Seyberth, Hannsjörg W

“…The molecular basis of inherited salt-losing tubular disorders with secondary hypokalemia has become much clearer in the past two decades. Two distinct…”
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Late-onset manifestation of antenatal bartter syndrome as a result of residual function of the mutated renal Na+-K+-2Cl- co-transporter by PRESSLER, Carsten A, HEINZINGER, Jolanta, JECK, Nikola, WALDEGGER, Petra, PECHMANN, Ulla, REINALTER, Stephan, KONRAD, Martin, BEETZ, Rolf, SEYBERTH, Hannsjörg W, WALDEGGER, Siegfried

“…Genetic defects of the Na+-K+-2Cl- (NKCC2) sodium potassium chloride co-transporter result in severe, prenatal-onset renal salt wasting accompanied by…”
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Functional and Structural Analysis of ClC-K Chloride Channels Involved in Renal Disease by Waldegger, Siegfried, Jentsch, Thomas J.

“…ClC-K channels belong to the CLC family of chloride channels and are predominantly expressed in the kidney. Genetic evidence suggests their involvement in…”
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A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity by Jeck, Nikola, Waldegger, Petra, Doroszewicz, Jolanta, Seyberth, Hannsjörg, Waldegger, Siegfried

“…A common sequence variation of the CLCNKB gene strongly activates ClC-Kb chloride channel activity. Tubular transepithelial reabsorption of chloride along the…”
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Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine by Busch, A E, Karbach, U, Miska, D, Gorboulev, V, Akhoundova, A, Volk, C, Arndt, P, Ulzheimer, J C, Sonders, M S, Baumann, C, Waldegger, S, Lang, F, Koepsell, H

“…Recently, we cloned the human cation transporter hOCT2, a member of a new family of polyspecific transporters from kidney, and demonstrated electrogenic uptake…”
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Salt wasting and deafness resulting from mutations in two chloride channels by SCHLINGMANN, Karl P, KONRAD, Martin, JECK, Nikola, WALDEGGER, Petra, REINALTER, Stephan C, HOLDER, Martin, SEYBERTH, Hannsjörg W, WALDEGGER, Siegfried

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