Search Results - "WALCH, Axel"

MALDI Imaging mass spectrometry: current frontiers and perspectives in pathology research and practice by Aichler, Michaela, Walch, Axel

“…MALDI Imaging mass spectrometry has entered the field of tissue-based research by providing unique advantages for analyzing tissue specimen in an unprecedented…”
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Bioengineered bacterial vesicles as biological nano-heaters for optoacoustic imaging by Gujrati, Vipul, Prakash, Jaya, Malekzadeh-Najafabadi, Jaber, Stiel, Andre, Klemm, Uwe, Mettenleiter, Gabriele, Aichler, Michaela, Walch, Axel, Ntziachristos, Vasilis

“…Advances in genetic engineering have enabled the use of bacterial outer membrane vesicles (OMVs) to deliver vaccines, drugs and immunotherapy agents, as a…”
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Morphometric Cell Classification for Single‐Cell MALDI‐Mass Spectrometry Imaging by Ščupáková, Klára, Dewez, Frédéric, Walch, Axel K., Heeren, Ron M. A., Balluff, Benjamin

“…The large‐scale and label‐free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We…”
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Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma by Ravi, Vidhya M, Will, Paulina, Kueckelhaus, Jan, Sun, Na, Joseph, Kevin, Salié, Henrike, Vollmer, Lea, Kuliesiute, Ugne, von Ehr, Jasmin, Benotmane, Jasim K, Neidert, Nicolas, Follo, Marie, Scherer, Florian, Goeldner, Jonathan M, Behringer, Simon P, Franco, Pamela, Khiat, Mohammed, Zhang, Junyi, Hofmann, Ulrich G, Fung, Christian, Ricklefs, Franz L, Lamszus, Katrin, Boerries, Melanie, Ku, Manching, Beck, Jürgen, Sankowski, Roman, Schwabenland, Marius, Prinz, Marco, Schüller, Ulrich, Killmer, Saskia, Bengsch, Bertram, Walch, Axel K, Delev, Daniel, Schnell, Oliver, Heiland, Dieter Henrik

“…Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The…”
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Patch repair of deep wounds by mobilized fascia by Correa-Gallegos, Donovan, Jiang, Dongsheng, Christ, Simon, Ramesh, Pushkar, Ye, Haifeng, Wannemacher, Juliane, Kalgudde Gopal, Shruthi, Yu, Qing, Aichler, Michaela, Walch, Axel, Mirastschijski, Ursula, Volz, Thomas, Rinkevich, Yuval

“…Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism 1 – 5 . Here we show that skin scars originate from…”
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The target landscape of clinical kinase drugs by Klaeger, Susan, Heinzlmeir, Stephanie, Wilhelm, Mathias, Polzer, Harald, Vick, Binje, Koenig, Paul-Albert, Reinecke, Maria, Ruprecht, Benjamin, Petzoldt, Svenja, Meng, Chen, Zecha, Jana, Reiter, Katrin, Qiao, Huichao, Helm, Dominic, Koch, Heiner, Schoof, Melanie, Canevari, Giulia, Casale, Elena, Re Depaolini, Stefania, Feuchtinger, Annette, Wu, Zhixiang, Schmidt, Tobias, Rueckert, Lars, Becker, Wilhelm, Huenges, Jan, Garz, Anne-Kathrin, Gohlke, Bjoern-Oliver, Zolg, Daniel Paul, Kayser, Gian, Vooder, Tonu, Preissner, Robert, Hahne, Hannes, Tõnisson, Neeme, Kramer, Karl, Götze, Katharina, Bassermann, Florian, Schlegl, Judith, Ehrlich, Hans-Christian, Aiche, Stephan, Walch, Axel, Greif, Philipp A., Schneider, Sabine, Felder, Eduard Rudolf, Ruland, Juergen, Médard, Guillaume, Jeremias, Irmela, Spiekermann, Karsten, Kuster, Bernhard

“…Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug…”
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Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces by Fischer, Adrian, Koopmans, Tim, Ramesh, Pushkar, Christ, Simon, Strunz, Maximilian, Wannemacher, Juliane, Aichler, Michaela, Feuchtinger, Annette, Walch, Axel, Ansari, Meshal, Theis, Fabian J., Schorpp, Kenji, Hadian, Kamyar, Neumann, Philipp-Alexander, Schiller, Herbert B., Rinkevich, Yuval

“…Surgical adhesions are bands of scar tissues that abnormally conjoin organ surfaces. Adhesions are a major cause of post-operative and dialysis-related…”
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Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels by Sun, Na, Walch, Axel

“…Mass spectrometry imaging (MSI) is a rapidly evolving technology that yields qualitative and quantitative distribution maps of small pharmaceutical-active…”
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A Novel Antifibrotic Mechanism of Nintedanib and Pirfenidone. Inhibition of Collagen Fibril Assembly by Knüppel, Larissa, Ishikawa, Yoshihiro, Aichler, Michaela, Heinzelmann, Katharina, Hatz, Rudolf, Behr, Jürgen, Walch, Axel, Bächinger, Hans Peter, Eickelberg, Oliver, Staab-Weijnitz, Claudia A

“…Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular matrix, in particular, collagens. Two IPF therapeutics,…”
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Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice by Stark, Konstantin, Philippi, Vanessa, Stockhausen, Sven, Busse, Johanna, Antonelli, Antonella, Miller, Meike, Schubert, Irene, Hoseinpour, Parandis, Chandraratne, Sue, von Brühl, Marie-Luise, Gaertner, Florian, Lorenz, Michael, Agresti, Alessandra, Coletti, Raffaele, Antoine, Daniel J., Heermann, Ralf, Jung, Kirsten, Reese, Sven, Laitinen, Iina, Schwaiger, Markus, Walch, Axel, Sperandio, Markus, Nawroth, Peter P., Reinhardt, Christoph, Jäckel, Sven, Bianchi, Marco E., Massberg, Steffen

“…Deep venous thrombosis (DVT) is one of the most common cardiovascular diseases, but its pathophysiology remains incompletely understood. Although sterile…”
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Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19 by Paul, Tanja, Ledderose, Stephan, Bartsch, Harald, Sun, Na, Soliman, Sarah, Märkl, Bruno, Ruf, Viktoria, Herms, Jochen, Stern, Marcel, Keppler, Oliver T., Delbridge, Claire, Müller, Susanna, Piontek, Guido, Kimoto, Yuki Schneider, Schreiber, Franziska, Williams, Tracy Ann, Neumann, Jens, Knösel, Thomas, Schulz, Heiko, Spallek, Ria, Graw, Matthias, Kirchner, Thomas, Walch, Axel, Rudelius, Martina

“…Progressive respiratory failure and hyperinflammatory response is the primary cause of death in the coronavirus disease 2019 (COVID-19) pandemic. Despite…”
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Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo by von Brühl, Marie-Luise, Stark, Konstantin, Steinhart, Alexander, Chandraratne, Sue, Konrad, Ildiko, Lorenz, Michael, Khandoga, Alexander, Tirniceriu, Anca, Coletti, Raffaele, Köllnberger, Maria, Byrne, Robert A, Laitinen, Iina, Walch, Axel, Brill, Alexander, Pfeiler, Susanne, Manukyan, Davit, Braun, Siegmund, Lange, Philipp, Riegger, Julia, Ware, Jerry, Eckart, Annekathrin, Haidari, Selgai, Rudelius, Martina, Schulz, Christian, Echtler, Katrin, Brinkmann, Volker, Schwaiger, Markus, Preissner, Klaus T, Wagner, Denisa D, Mackman, Nigel, Engelmann, Bernd, Massberg, Steffen

“…Deep vein thrombosis (DVT) is a major cause of cardiovascular death. The sequence of events that promote DVT remains obscure, largely as a result of the lack…”
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Proton Minibeam Radiation Therapy Reduces Side Effects in an In Vivo Mouse Ear Model by Girst, Stefanie, MS, Greubel, Christoph, PhD, Reindl, Judith, MSc, Siebenwirth, Christian, MS, Zlobinskaya, Olga, PhD, Walsh, Dietrich W.M., MSc, Ilicic, Katarina, MSc, Aichler, Michaela, PhD, Walch, Axel, PhD, Wilkens, Jan J., PhD, Multhoff, Gabriele, PhD, Dollinger, Günther, PhD, Schmid, Thomas E., PhD

“…Purpose Proton minibeam radiation therapy is a novel approach to minimize normal tissue damage in the entrance channel by spatial fractionation while keeping…”
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Mass Spectrometry Imaging Establishes 2 Distinct Metabolic Phenotypes of Aldosterone-Producing Cell Clusters in Primary Aldosteronism by Sun, Na, Meyer, Lucie S., Feuchtinger, Annette, Kunzke, Thomas, Knösel, Thomas, Reincke, Martin, Walch, Axel, Williams, Tracy Ann

“…Aldosterone-producing adenomas (APAs) are one of the main causes of primary aldosteronism and the most prevalent surgically correctable form of hypertension…”
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Efficient isolation of pure and functional mitochondria from mouse tissues using automated tissue disruption and enrichment with anti-TOM22 magnetic beads by Franko, Andras, Baris, Olivier R, Bergschneider, Eva, von Toerne, Christine, Hauck, Stefanie M, Aichler, Michaela, Walch, Axel K, Wurst, Wolfgang, Wiesner, Rudolf J, Johnston, Ian C D, de Angelis, Martin Hrabĕ

“…To better understand molecular mechanisms regulating changes in metabolism, as observed e.g. in diabetes or neuronal disorders, the function of mitochondria…”
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High-mass-resolution MALDI mass spectrometry imaging of metabolites from formalin-fixed paraffin-embedded tissue by Ly, Alice, Buck, Achim, Balluff, Benjamin, Sun, Na, Gorzolka, Karin, Feuchtinger, Annette, Janssen, Klaus-Peter, Kuppen, Peter J K, van de Velde, Cornelis J H, Weirich, Gregor, Erlmeier, Franziska, Langer, Rupert, Aubele, Michaela, Zitzelsberger, Horst, McDonnell, Liam, Aichler, Michaela, Walch, Axel

“…Formalin-fixed paraffin embedding (FFPE) of tissues has been assumed to alter the metabolite content or chemical state, hampering metabolomics studies. Here,…”
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Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis by Sato, Shogo, Dyar, Kenneth A., Treebak, Jonas T., Jepsen, Sara L., Ehrlich, Amy M., Ashcroft, Stephen P., Trost, Kajetan, Kunzke, Thomas, Prade, Verena M., Small, Lewin, Basse, Astrid Linde, Schönke, Milena, Chen, Siwei, Samad, Muntaha, Baldi, Pierre, Barrès, Romain, Walch, Axel, Moritz, Thomas, Holst, Jens J., Lutter, Dominik, Zierath, Juleen R., Sassone-Corsi, Paolo

“…Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a…”
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MALDI imaging mass spectrometry in cancer research: Combining proteomic profiling and histological evaluation by Schöne, Cédrik, Höfler, Heinz, Walch, Axel

“…Despite the tendency to regard tumors as a simple mass of cancer cells, tumors have a high degree of complexity that is difficult to access with most…”
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Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid by Düwel, Stephan, Hundshammer, Christian, Gersch, Malte, Feuerecker, Benedikt, Steiger, Katja, Buck, Achim, Walch, Axel, Haase, Axel, Glaser, Steffen J., Schwaiger, Markus, Schilling, Franz

“…Natural pH regulatory mechanisms can be overruled during several pathologies such as cancer, inflammation and ischaemia, leading to local pH changes in the…”
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Fluorescent blood–brain barrier tracing shows intact leptin transport in obese mice by Harrison, Luke, Schriever, Sonja C., Feuchtinger, Annette, Kyriakou, Eleni, Baumann, Peter, Pfuhlmann, Katrin, Messias, Ana C., Walch, Axel, Tschöp, Matthias H., Pfluger, Paul T.

“…Background/objectives Individuals carrying loss-of-function gene mutations for the adipocyte hormone leptin are morbidly obese, but respond favorably to…”
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