Search Results - "WALAWANDER, C. A"

Hemodynamic effects of propofol : data from over 25,000 patients by HUG, C. C, MCLESKEY, C. H, NAHRWOLD, M. L, ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WALAWANDER, C. A, WHITE, P. F, APFELBAUM, J. L, GRASELA, T. H

“…To investigate clinically important hypotension and bradycardia after induction of anesthesia with propofol, we analyzed data from a Phase IV stepwise study…”
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Symptomatic Cardiotoxicity Associated with 5-Fluorouracil by Meyer, Christine C., Calis, Karim Anton, Burke, Laurie B., Walawander, Cynthia A., Grasela, Thaddeus H.

“…A prospective cohort study was conducted in 35 hospitals with oncology units to determine the incidence of symptomatic cardiotoxicity in patients receiving…”
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The Clinical Evaluation of New Drugs for Sepsis: A Prospective Study Design Based on Survival Analysis by Knaus, William A, Harrell, Frank E, Fisher, Charles J, Wagner, Douglas P, Opal, Steven M, Sadoff, Jerald C, Draper, Elizabeth A, Walawander, Cynthia A, Conboy, Kathleen, Grasela, Thaddeus H

“…Objective.—To develop a survival model and severity assessment method to estimate the 28-day mortality risk for patients with sepsis syndrome entering phase 2…”
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The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol : characteristics associated with prolonged time to awakening by APFELBAUM, J. L, GRASELA, T. H, HUG, C. C, MCLESKEY, C. H, NAHRWOLD, M. L, ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WALAWANDER, C. A, WHITE, P. F

“…In October 1989, propofol underwent Phase IV Food and Drug Administration testing that involved 25,981 patients, 1722 institutions, and 1819 anesthesiologists…”
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Pretreatment Regimens for Adverse Events Related to Infusion of Amphotericin B by Goodwin, S. Diane, Cleary, John D., Walawander, Cynthia A., Taylor, Jerry W., Grasela, Thaddeus H.

“…Infusion-related adverse events (IRAEs) such as nausea, vomiting, fever, chills, and thrombophlebitis that are associated with amphotericin B therapy often…”
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Adverse events in a multicenter phase IV study of propofol : evaluation by anesthesiologists and postanesthesia care unit nurses by MCLESKEY, C. H, WALAWANDER, C. A, NAHRWOLD, M. L, ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WHITE, P. F, APFELBAUM, J. L, GRASELA, T. H, HUG, C. C

“…Phase II and III studies are tightly controlled trials investigating adverse effects before government approval of a new drug. However, because postapproval…”
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Analysis of Potential Risk Factors Associated with the Development of Pancreatitis in Phase I Patients with AIDS or AIDS-Related Complex Receiving Didanosine by Grasela, Thaddeus H., Walawander, Cynthia A., Beltangady, Mohan, Knupp, Catherine A., Martin, Russell R., Dunkle, Lisa M., Barbhaiya, Rashmi H., Pittman, Kenneth A., Dolin, Raphael, Valentine, Fred T., Liebman, Howard A.

“…Phase I dose-escalating trials of didanosine revealeddose-limiting toxicities, including pancreatitis, and established a total daily dose of 12.5 mg/kg/day as…”
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Sepsis syndrome and associated sequelae in patients at high risk for gram-negative sepsis by Conboy, K, Welage, L S, Walawander, C A, Duffy, L C, Welliver, R C, Zielezny, M A, DiPiro, J T, Raebel, M A, Grasela, T H

“…We conducted a prospective surveillance study of 80 hospitals across the United States to determine the incidence of sepsis syndrome and its associated…”
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Phase IV study of propofol : validation of the data set by NAHRWOLD, M. L, ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WALAWANDER, C. A, WHITE, P. F, APFELBAUM, J. L, GRASELA, T. H, HUG, C. C, MCLESKEY, C. H

“…In 1989-1990, Stuart Pharmaceuticals conducted a Phase IV study of propofol on over 26,000 patients, later making the large data base available to a team of…”
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Effects on recovery when isoflurane is used to supplement propofol-nitrous oxide anesthesia by WHITE, P. F, STANLEY, T. H, APFELBAUM, J. L, GRASELA, T. H, HUG, C. C, MCLESKEY, C. H, NAHRWOLD, M. L, ROIZEN, M. F, THISTED, R. A, WALAWANDER, C. A

“…During propofol-nitrous oxide (N2O) anesthesia, volatile anesthetics are frequently administered to treat signs of inadequate anesthesia and to decrease the…”
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Adverse drug reaction reporting in a multicenter surveillance study by Timm, E G, Welage, L S, Walawander, C A, Sayers, J F, Karpiuk, E L, Davis, T D, Grasela, Jr, T H

“…To evaluate the performance of a multicenter, prospective surveillance program in identifying adverse events, and to seek explanations for misclassification…”
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The role of pharmacoepidemiology research in postmarketing surveillance and anesthesia practice/critical care medicine by GRASELA, T. H, WATKINS, W. D, APFELBAUM, J. L, HUG, C. C, MCLESKEY, C. H, NAHRWOLD, M. L, ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WALAWANDER, C. A, WHITE, P. F

“…Despite tremendous efforts to ensure the safety and effectiveness of newly marketed medications, a number of these have had significant problems after…”
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How do anesthesiologists select patients when introducing a new drug into practice ? by ROIZEN, M. F, STANLEY, T. H, THISTED, R. A, WALAWANDER, C. A, WHITE, P. F, APFELBAUM, J. L, GRASELA, T. H, HUG, C. C, MCLESKEY, C. H, HAHRWOLD, M. L

“…As part of the marketing strategy for the anesthetic drug propofol (Diprivan), Stuart Pharmaceuticals began a Phase IV postmarketing study soon after the drug…”
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Capability of hospital computer systems in performing drug-use evaluations and adverse drug event monitoring by Grasela, T H, Walawander, C A, Kennedy, D L, Jolson, H M

“…A survey to determine the extent of computerization in key areas of hospitals, the information being collected in the databases, and the capabilities of the…”
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Risk factors for acute renal insufficiency in patients with suspected or documented bacterial pneumonia by Welage, L S, Walawander, C A, Timm, E G, Grasela, T H

“…To describe the incidence of acute renal insufficiency and identify potential risk factors associated with this adverse medical event. A cohort analytic study…”
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Alternatives to intravenous tetracycline hydrochloride for malignant pleural effusions by Grasela, T H, Walawander, C A, Jolson, H M, Kennedy, D L

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Prospective evaluation of risk factors for antibiotic-associated bleeding in critically ill patients by Goss, T F, Walawander, C A, Grasela, Jr, T H, Meisel, S, Katona, B, Jaynes, K

“…A prospective surveillance program was initiated to determine the relative role of antibiotics containing N-methylthiotetrazole (NMTT) versus patient risk…”
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The influence of intravenous cimetidine dosage regimens on the disposition of theophylline by Gutfeld, M B, Welage, L S, Walawander, C A, Wilton, J H, Harrison, N J

“…The influence of the method of cimetidine administration on theophylline disposition was studied in nine healthy, cigarette smoking male volunteers. The…”
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A nationwide survey of antibiotic prescribing patterns and clinical outcomes in patients with bacterial pneumonia by Grasela, Jr, T H, Welage, L S, Walawander, C A, Timm, E G, Pelter, M A, Poirier, T I, Walters, J K

“…Antibiotic prescribing information was prospectively collected on 1822 hospitalized patients treated for suspected or documented bacterial pneumonia…”
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Applying epidemiology-based outcomes research to clinical decision-making. A hypothetical model of biotechnology therapy in gram-negative sepsis by Wang, E C, Grasela, T H, Walawander, C A

“…Sepsis occurs in a heterogeneous population. A prospective nationwide surveillance study found that populations stratified by infection type had significant…”
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