Search Results - "WAKIOKA, T"

APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl by WAKIOKA, T, SASAKI, A, MITSUI, K, YOKOUCHI, M, INOUE, A, KOMIYA, S, YOSHIMURA, A

“…We cloned a novel adaptor protein, APS (adaptor molecule containing Pleckstrin homology (PH) and Src Homology-2 (SH2) domains), which was tyrosine…”
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Spred is a Sprouty-related suppressor of Ras signalling by Yoshimura, Akihiko, Wakioka, Toru, Sasaki, Atsuo, Kato, Reiko, Shouda, Takanori, Matsumoto, Akira, Miyoshi, Kanta, Tsuneoka, Makoto, Komiya, Setsuro, Baron, Roland

“…Cellular proliferation, and differentiation of cells in response to extracellular signals, are controlled by the signal transduction pathway of Ras, Raf and…”
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Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis by Shouda, T, Yoshida, T, Hanada, T, Wakioka, T, Oishi, M, Miyoshi, K, Komiya, S, Kosai, K, Hanakawa, Y, Hashimoto, K, Nagata, K, Yoshimura, A

“…Immune and inflammatory systems are controlled by multiple cytokines, including ILs and INFs. These cytokines exert their biological functions through Janus…”
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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop by Yasukawa, Hideo, Misawa, Hiroyuki, Sakamoto, Hiroshi, Masuhara, Masaaki, Sasaki, Atsuo, Wakioka, Toru, Ohtsuka, Satoshi, Imaizumi, Tsutomu, Matsuda, Tadashi, Ihle, James N., Yoshimura, Akihiko

“…The Janus family of protein tyrosine kinases (JAKs) regulate cellular processes involved in cell growth, differentiation and transformation through their…”
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Identification of a Dominant Negative Mutant of Sprouty That Potentiates Fibroblast Growth Factor- but Not Epidermal Growth Factor-induced ERK Activation by Sasaki, Atsuo, Taketomi, Takaharu, Wakioka, Toru, Kato, Reiko, Yoshimura, Akihiko

“…Various mitogenic stimuli such as epidermal growth factor (EGF), fibroblast growth factor (FGF), and phorbol 12,13-dibutyrate (PDBu) activate the…”
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The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization by MIYOSHI, Kanta, WAKIOKA, Toru, NISHINAKAMURA, Hitomi, KAMIO, Masaki, LU YANG, INOUE, Makoto, HASEGAWA, Mamoru, YONEMITSU, Yoshikazu, KOMIYA, Setsuro, YOSHIMURA, Akihiko

“…Sprouty and the Sprouty-related protein, Spred (Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology-1 (EVH1) domain-containing protein), inhibit…”
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Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation by Kato, Reiko, Nonami, Atsushi, Taketomi, Takaharu, Wakioka, Toru, Kuroiwa, Asato, Matsuda, Yoichi, Yoshimura, Akihiko

“…We have reported on Spred-1 and Spred-2, which inhibit MAP kinase activation by interacting with c-kit and ras/raf. Here, we report the cloning of a third…”
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Cloning and Characterization of Novel CIS Family Genes by Masuhara, Masaaki, Sakamoto, Hiroshi, Matsumoto, Akira, Suzuki, Ritsu, Yasukawa, Hideo, Mitsui, Kaoru, Wakioka, Toru, Tanimura, Shyu, Sasaki, Atsuo, Misawa, Hiroyuki, Yokouchi, Masahiro, Ohtsubo, Motoaki, Yoshimura, Akihiko

“…We have reported two JAK-signaling modulators, CIS (cytokine-inducible SH2 protein) and JAB (JAK2 binding protein), which are structurally related. Here we…”
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CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells by SUZUKI, R, SAKAMOTO, H, YASUKAWA, H, MASUHARA, M, WAKIOKA, T, SASAKI, A, YUGE, K, KOMIYA, S, INOUE, A, YOSHIMURA, A

“…We have reported JAK-signaling modulators, CIS1 (cytokine-inducible SH2 protein-1), CIS3 and JAB (JAK2 binding protein), which are structurally related. In M1…”
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APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis by YOKOUCHI, M, WAKIOKA, T, YOSHIMURA, A, SAKAMOTO, H, YASUKAWA, H, OHTSUKA, S, SASAKI, A, OHTSUBO, M, VALIUS, M, INOUE, A, KOMIYA, S

“…Previously we cloned a novel adaptor protein, APS (adaptor molecules containing PH and SH2 domains) which was tyrosine phosphorylated in response to c-kit or B…”
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