Search Results - "WAI-YEE CHAN"

MicroRNAs: Key Regulators in the Central Nervous System and Their Implication in Neurological Diseases by Cao, Dan-Dan, Li, Lu, Chan, Wai-Yee

“…MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate gene expression post-transcriptionally. They have been demonstrated to…”
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Long noncoding RNA HCP5 participates in premature ovarian insufficiency by transcriptionally regulating MSH5 and DNA damage repair via YB1 by Wang, Xiaoyan, Zhang, Xinyue, Dang, Yujie, Li, Duan, Lu, Gang, Chan, Wai-Yee, Leung, Peter C K, Zhao, Shidou, Qin, Yingying, Chen, Zi-Jiang

“…The genetic etiology of premature ovarian insufficiency (POI) has been well established to date, however, the role of long noncoding RNAs (lncRNAs) in POI is…”
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Fertility factors affect the vaginal microbiome in women of reproductive age by Xu, Jieying, Bian, Gaorui, Zheng, Min, Lu, Gang, Chan, Wai‐Yee, Li, Weiping, Yang, Kaiping, Chen, Zi‐Jiang, Du, Yanzhi

“…Problem For women of reproductive age, achieving a successful pregnancy requires both the normal functioning of reproductive endocrine and the health of the…”
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A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes by Li, Qiuhong, Hutchins, Andrew P., Chen, Yong, Li, Shengbiao, Shan, Yongli, Liao, Baojian, Zheng, Dejin, Shi, Xi, Li, Yinxiong, Chan, Wai-Yee, Pan, Guangjin, Wei, Shicheng, Shu, Xiaodong, Pei, Duanqing

“…Reprogramming has been shown to involve EMT–MET; however, its role in cell differentiation is unclear. We report here that in vitro differentiation of hESCs to…”
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Maternal obesity: A potential disruptor of female fertility and current interventions to reduce associated risks by Muhammad, Tahir, Wan, Yanling, Lv, Yue, Li, Hanzhen, Naushad, Wasifa, Chan, Wai-Yee, Lu, Gang, Chen, Zi-Jiang, Liu, Hongbin

“…Currently, obesity has achieved epidemic levels in reproductive-aged women with a myriad of consequences. Obesity is susceptible to several reproductive…”
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The Role of microRNAs in Ovarian Granulosa Cells in Health and Disease by Tu, Jiajie, Cheung, Albert Hoi-Hung, Chan, Clement Leung-Kwok, Chan, Wai-Yee

“…The granulosa cell (GC) is a critical somatic component of the ovary. It is essential for follicle development by supporting the developing oocyte,…”
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Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation by Li, Wei, Long, Qi, Wu, Hao, Zhou, Yanshuang, Duan, Lifan, Yuan, Hao, Ding, Yingzhe, Huang, Yile, Wu, Yi, Huang, Jinyu, Liu, Delong, Chen, Baodan, Zhang, Jian, Qi, Juntao, Du, Shiwei, Li, Linpeng, Liu, Yang, Ruan, Zifeng, Liu, Zihuang, Liu, Zichao, Zhao, Yifan, Lu, Jianghuan, Wang, Junwei, Chan, Wai-Yee, Liu, Xingguo

“…Pluripotent stem cells hold great promise in regenerative medicine and developmental biology studies. Mitochondrial metabolites, including tricarboxylic acid…”
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The single-cell chromatin landscape in gonadal cell lineage specification by Suen, Hoi Ching, Ou, Fanghong, Miu, Kai-Kei, Wang, Zhangting, Chan, Wai-Yee, Liao, Jinyue

“…Gonad development includes sex determination and divergent maturation of the testes and ovaries. Recent advances in measuring gene expression in single cells…”
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Long noncoding RNAs in spermatogenesis: insights from recent high-throughput transcriptome studies by Luk, Alfred Chun-Shui, Chan, Wai-Yee, Rennert, Owen M, Lee, Tin-Lap

“…Spermatogenesis is a complex developmental process in which undifferentiated spermatogonia are differentiated into spermatocytes and spermatids through two…”
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WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome by Tian, Yuyao, Wang, Wuming, Lautrup, Sofie, Zhao, Hui, Li, Xiang, Law, Patrick Wai Nok, Dinh, Ngoc-Duy, Fang, Evandro Fei, Cheung, Hoi Hung, Chan, Wai-Yee

“…Werner Syndrome (WS) is an autosomal recessive disorder characterized by premature aging due to mutations of the WRN gene. A classical sign in WS patients is…”
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SPIDR is required for homologous recombination during mammalian meiosis by Huang, Tao, Wu, Xinyue, Wang, Shiyu, Bao, Ziyou, Wan, Yanling, Wang, Ziqi, Li, Mengjing, Yu, Xiaochen, Lv, Yue, Liu, Zhaojian, Chen, Xiangfeng, Chan, Wai-Yee, Gao, Fei, Lu, Gang, Chen, Zi-Jiang, Liu, Hongbin

“…Abstract Meiotic recombinases RAD51 and DMC1 mediate strand exchange in the repair of DNA double-strand breaks (DSBs) by homologous recombination. This is a…”
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Melatonin as Potential Targets for Delaying Ovarian Aging by Yang, Yanzhou, Cheung, Hoi-Hung, Zhang, Cheng, Wu, Ji, Chan, Wai-Yee

“…In previous studies, oxidative stress damage has been solely considered to be the mechanism of ovarian aging, and several antioxidants have been used to delay…”
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Flexible and versatile as a chameleon-sophisticated functions of microRNA-199a by Gu, Shen, Chan, Wai-Yee

“…Although widely studied in the past decade, our knowledge of the functional role of microRNAs (miRNAs) remains limited. Among the many miRNAs identified in…”
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Genetic correction of Werner syndrome gene reveals impaired pro‐angiogenic function and HGF insufficiency in mesenchymal stem cells by Tu, Jiajie, Wan, Chao, Zhang, Fengjie, Cao, Lianbao, Law, Patrick Wai Nok, Tian, Yuyao, Lu, Gang, Rennert, Owen M., Chan, Wai‐Yee, Cheung, Hoi‐Hung

“…WRN mutation causes a premature aging disease called Werner syndrome (WS). However, the mechanism by which WRN loss leads to progeroid features evident with…”
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Changes in the vaginal microbiota associated with primary ovarian failure by Wang, Juan, Xu, Jieying, Han, Qixin, Chu, Weiwei, Lu, Gang, Chan, Wai-Yee, Qin, Yingying, Du, Yanzhi

“…Primary ovarian failure (POF) is defined as follicular failure in women of reproductive age. Although many factors are speculated to contribute to the…”
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Single-Oocyte Gene Expression Suggests That Curcumin Can Protect the Ovarian Reserve by Regulating the PTEN-AKT-FOXO3a Pathway by Lv, Yue, Cao, Rui-Can, Liu, Hong-Bin, Su, Xian-Wei, Lu, Gang, Ma, Jin-Long, Chan, Wai-Yee

“…A better understanding of the mechanism of primordial follicle activation will help us better understand the causes of premature ovarian insufficiency (POI),…”
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LRRC46 Accumulates at the Midpiece of Sperm Flagella and Is Essential for Spermiogenesis and Male Fertility in Mouse by Yin, Yingying, Mu, Wenyu, Yu, Xiaochen, Wang, Ziqi, Xu, Ke, Wu, Xinyue, Cai, Yuling, Zhang, Mingyu, Lu, Gang, Chan, Wai-Yee, Ma, Jinlong, Huang, Tao, Liu, Hongbin

“…The sperm flagellum is essential for male fertility. Multiple morphological abnormalities of the sperm flagella (MMAF) is a severe form of…”
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A miR-199a/miR-214 Self-Regulatory Network via PSMD10, TP53 and DNMT1 in Testicular Germ Cell Tumor by Chen, Bi-Feng, Suen, Yick-Keung, Gu, Shen, Li, Lu, Chan, Wai-Yee

“…It was previously demonstrated that microRNA-199a (miR-199a) was down-regulated in testicular germ cell tumor (TGCT) partially caused by hypermethylation of…”
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An epigenetic regulator: methyl-CpG-binding domain protein 1 (MBD1) by Li, Lu, Chen, Bi-Feng, Chan, Wai-Yee

“…DNA methylation is an important form of epigenetic regulation in both normal development and cancer. Methyl-CpG-binding domain protein 1 (MBD1) is highly…”
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Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming by Wu, Yasong, Li, Yuan, Zhang, Hui, Huang, Yinghua, Zhao, Ping, Tang, Yujia, Qiu, Xiaohui, Ying, Yue, Li, Wen, Ni, Su, Zhang, Meng, Liu, Longqi, Xu, Yan, Zhuang, Qiang, Luo, Zhiwei, Benda, Christina, Song, Hong, Liu, Baohua, Lai, Liangxue, Liu, Xingguo, Tse, Hung-Fat, Bao, Xichen, Chan, Wai-Yee, A. Esteban, Miguel, Qin, Baoming, Pei, Duanqing

“…We describe robust induction of autophagy during the reprogramming of mouse fibroblasts to induced pluripotent stem cells by four reprogramming factors (Sox2,…”
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