Search Results - "WAI LEE WONG"

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates by Shen, Ben-Quan, Xu, Keyang, Liu, Luna, Raab, Helga, Bhakta, Sunil, Kenrick, Margaret, Parsons-Reponte, Kathryn L, Tien, Janet, Yu, Shang-Fan, Mai, Elaine, Li, Dongwei, Tibbitts, Jay, Baudys, Jakub, Saad, Ola M, Scales, Suzie J, McDonald, Paul J, Hass, Philip E, Eigenbrot, Charles, Nguyen, Trung, Solis, Willy A, Fuji, Reina N, Flagella, Kelly M, Patel, Darshana, Spencer, Susan D, Khawli, Leslie A, Ebens, Allen, Wong, Wai Lee, Vandlen, Richard, Kaur, Surinder, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul, Junutula, Jagath R

“…Conjugating drugs to therapeutic antibodies is a promising strategy to increase their therapeutic efficacy. Shen et al. show that the local chemical…”
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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index by Junutula, Jagath R, Mallet, William, Raab, Helga, Clark, Suzanna, Bhakta, Sunil, Leipold, Douglas D, Weir, Sylvia, Chen, Yvonne, Simpson, Michelle, Tsai, Siao Ping, Dennis, Mark S, Lu, Yanmei, Meng, Y Gloria, Ng, Carl, Yang, Jihong, Lee, Chien C, Duenas, Eileen, Gorrell, Jeffrey, Katta, Viswanatham, Kim, Amy, McDorman, Kevin, Flagella, Kelly, Venook, Rayna, Ross, Sarajane, Spencer, Susan D, Lee Wong, Wai, Lowman, Henry B, Vandlen, Richard, Sliwkowski, Mark X, Scheller, Richard H, Polakis, Paul

“…Systemic toxicity associated with heterogeneity in the stoichiometries and sites of drug attachment is a major hurdle to developing antibody-drug conjugates…”
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Convergent and Divergent Ligand Specificity among PDZ Domains of the LAP and Zonula Occludens (ZO) Families by Zhang, Yingnan, Yeh, Sherry, Appleton, Brent A., Held, Heike A., Kausalya, P. Jaya, Phua, Dominic C.Y., Lee Wong, Wai, Lasky, Laurence A., Wiesmann, Christian, Hunziker, Walter, Sidhu, Sachdev S.

“…We present a detailed comparative analysis of the PDZ domains of the human LAP proteins Erbin, Densin-180, and Scribble and the MAGUK ZO-1. Phage-displayed…”
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The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin by Nguyen, Allen, Reyes, Arthur E., Zhang, Min, McDonald, Paul, Wong, Wai Lee T., Damico, Lisa A., Dennis, Mark S.

“…An AB.Fab (albumin-binding Fab) consists of a Fab and a phage-derived albumin-binding peptide. This molecule is capable of binding both antigen and albumin…”
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Total Antibody Quantification for MMAE-Conjugated Antibody–Drug Conjugates: Impact of Assay Format and Reagents by Kozak, Katherine R, Tsai, Siao Ping, Fourie-O’Donohue, Aimee, dela Cruz Chuh, Josefa, Roth, Leslie, Cook, Ryan, Chan, Elton, Chan, Pamela, Darwish, Martine, Ohri, Rachana, Raab, Helga, Zhang, Crystal, Lin, Kedan, Wong, Wai Lee T

“…Antibody–drug conjugates (ADCs) are target-specific anticancer agents consisting of cytotoxic drugs covalently linked to a monoclonal antibody. The number of…”
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Targeting HER2-positive breast cancer with trastuzumab-DM1, an antibody-cytotoxic drug conjugate by Lewis Phillips, Gail D, Li, Guangmin, Dugger, Debra L, Crocker, Lisa M, Parsons, Kathryn L, Mai, Elaine, Blättler, Walter A, Lambert, John M, Chari, Ravi V J, Lutz, Robert J, Wong, Wai Lee T, Jacobson, Frederic S, Koeppen, Hartmut, Schwall, Ralph H, Kenkare-Mitra, Sara R, Spencer, Susan D, Sliwkowski, Mark X

“…HER2 is a validated target in breast cancer therapy. Two drugs are currently approved for HER2-positive breast cancer: trastuzumab (Herceptin), introduced in…”
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Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration by Lu, Yanmei, Xiang, Hong, Liu, Peter, Tong, Raymond R., Watts, Ryan J., Koch, Alexander W., Sandoval, Wendy N., Damico, Lisa A., Wong, Wai Lee, Meng, Y. Gloria

“…Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer…”
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A New ELISA for Use in a 3-ELISA System to Assess Concentrations of VEGF Splice Variants and VEGF110 in Ovarian Cancer Tumors by Gutierrez, Johnny, Konecny, Gottfried E, Hong, Kyu, Burges, Alexander, Henry, Timothy D, Lambiase, Pier D, Lee Wong, Wai, Meng, Y. Gloria

“…Background: Vascular endothelial growth factor (VEGF), which affects tumor angiogenesis, is expressed as different splice variants, including the major…”
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Increased physical activity and the growth hormone-IGF-I axis in adolescent males by Eliakim, A, Brasel, J A, Mohan, S, Wong, W L, Cooper, D M

“…Insulin-like growth factor-I (IGF-I) is associated with muscle hypertrophy, and circulating IGF-I levels are correlated with fitness. To test the hypothesis…”
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Challenges in developing bioanalytical assays for characterization of antibody-drug conjugates by Stephan, Jean Philippe, Kozak, Katherine R, Wong, Wai Lee T

“…With more than 34 targets being investigated and nearly 20 clinical trials at various phases of development, antibody-drug conjugates (ADCs) hold a lot of…”
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Micro-volume wall-less immunoassays using patterned planar plates by Kozak, Katherine R, Wang, Jianyong, Lye, Melvin, Chuh, Josefa dela Cruz, Takkar, Rashi, Kim, Namyong, Lee, Hyunjae, Jeon, Noo Li, Lin, Kedan, Zhang, Crystal, Wong, Wai Lee T, DeForge, Laura E

“…Miniaturization of immunoassays has numerous potential advantages over traditional ELISAs. Here we present a novel approach using patterned planar plates…”
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Anti-CD22-MCC-DM1 and MC-MMAF Conjugates: Impact of Assay Format on Pharmacokinetic Parameters Determination by Stephan, Jean-Philippe, Chan, Pamela, Lee, Chien, Nelson, Christopher, Elliott, James Michael, Bechtel, Charity, Raab, Helga, Xie, David, Akutagawa, Jon, Baudys, Jakub, Saad, Ola, Prabhu, Saileta, Wong, Wai Lee T, Vandlen, Richard, Jacobson, Fred, Ebens, Allen

“…CD22 represents a promising target for antibody−drug conjugate therapy in the context of B cell malignancies since it rapidly internalizes, importing…”
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Evaluation of heterophilic antibody blocking agents in reducing false positive interference in immunoassays for IL-17AA, IL-17FF, and IL-17AF by DeForge, Laura E., Loyet, Kelly M., Delarosa, Donnie, Chinn, Jason, Zamanian, Fojan, Chuntharapai, Anan, Lee, James, Hass, Phil, Wei, Nathan, Townsend, Michael J., Wang, Jianyong, Wong, Wai Lee T.

“…IL-17AA, IL-17FF, and IL-17AF are proinflammatory cytokines that have been implicated in the pathogenesis of autoimmune diseases such as rheumatoid arthritis…”
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Identification and characterization of binding proteins for inhibin and activin in human serum and follicular fluids by Krummen, L A, Woodruff, T K, DeGuzman, G, Cox, E T, Baly, D L, Mann, E, Garg, S, Wong, W L, Cossum, P, Mather, J P

“…Inhibins and activins are produced by a variety of tissues and may have important endocrine and paracrine roles in development, reproduction, and…”
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Identification of IgG1 variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays by Lu, Yanmei, Vernes, Jean-Michel, Chiang, Nancy, Ou, Qinglin, Ding, Jiabing, Adams, Camellia, Hong, Kyu, Truong, Bao-Tran, Ng, Domingos, Shen, Amy, Nakamura, Gerald, Gong, Qian, Presta, Leonard G., Beresini, Maureen, Kelley, Bob, Lowman, Henry, Wong, Wai Lee, Meng, Y. Gloria

“…Clinical response to the anti-CD20 antibody rituximab has been demonstrated to correlate with the polymorphism in the FcγRIIIa receptor where patients…”
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HER2-Targeted Therapy Reduces Incidence and Progression of Midlife Mammary Tumors in Female Murine Mammary Tumor Virus huHER2-Transgenic Mice by FINKLE, David, ZHI RICKY QUAN, ERICKSON, Sharon, ASGHARI, Vida, KLOSS, Jessica, GHABOOSI, Nazli, MAI, Elaine, WAI LEE WONG, HOLLINGSHEAD, Philip, SCHWALL, Ralph, KOEPPEN, Hartmut

“…Purpose: This study examined the effectiveness of early and prolonged mu4D5 (the murine form of trastuzumab/Herceptin) treatment in transgenic mice that…”
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Ligand-mediated immunofunctional assay for quantitation of growth hormone-binding protein in human blood by Carlsson, L M, Rowland, A M, Clark, R G, Gesundheit, N, Wong, W L

“…Human serum contains a high affinity GH-binding protein (GHBP) whose amino-terminal sequence is identical to the extracellular domain of the GH receptor…”
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Design, Construction, and In Vitro Analyses of Multivalent Antibodies by Miller, Kathy, Meng, Gloria, Liu, Jun, Hurst, Amy, Hsei, Vanessa, Wong, Wai-Lee, Ekert, Rene, Lawrence, David, Sherwood, Steven, DeForge, Laura, Gaudreault, Jacques, Keller, Gilbert, Sliwkowski, Mark, Ashkenazi, Avi, Presta, Leonard

“…Some Abs are more efficacious after being cross-linked to form dimers or multimers, presumably as a result of binding to and clustering more surface target to…”
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A new ELISA for use in a 3-ELISA system to assess concentrations of VEGF splice variants and VEGF(110) in ovarian cancer tumors by Gutierrez, Johnny, Konecny, Gottfried E, Hong, Kyu, Burges, Alexander, Henry, Timothy D, Lambiase, Pier D, Lee Wong, Wai, Meng, Y Gloria

“…Vascular endothelial growth factor (VEGF), which affects tumor angiogenesis, is expressed as different splice variants, including the major isoforms VEGF(165)…”
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Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells : a model of glioblastoma multiforme pathophysiology by GOLDMAN, C. K, JIN KIM, WAI-LEE WONG, KING, V, BROCK, T, GILLESPIE, G. Y

“…Hypervascularity, focal necrosis, persistent cerebral edema, and rapid cellular proliferation are key histopathologic features of glioblastoma multiforme…”
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