Search Results - "WAHLSTRÖM, Jan"

Immunogenetics of Disease-Causing Inflammation in Sarcoidosis by Grunewald, Johan, Spagnolo, Paolo, Wahlström, Jan, Eklund, Anders

“…Sarcoidosis is a systemic inflammatory disorder characterised by tissue infiltration by mononuclear phagocytes and lymphocytes with associated non-caseating…”
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Bronchoalveolar lavage fluid cell subsets associate with the disease course in Löfgren's and non-Löfgren's sarcoidosis patients by Abo Al Hayja, Muntasir, Wahlström, Jan, Kullberg, Susanna, Darlington, Pernilla, Eklund, Anders, Grunewald, Johan

“…Sarcoidosis is a multisystem granulomatous inflammatory disorder, that predominantly involves the lungs. Patients with Löfgren's syndrome (LS) are…”
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A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease by Östensson, Malin, Montén, Caroline, Bacelis, Jonas, Gudjonsdottir, Audur H, Adamovic, Svetlana, Ek, Johan, Ascher, Henry, Pollak, Elisabet, Arnell, Henrik, Browaldh, Lars, Agardh, Daniel, Wahlström, Jan, Nilsson, Staffan, Torinsson-Naluai, Åsa

“…Celiac disease is a common autoimmune disorder characterized by an intestinal inflammation triggered by gluten, a storage protein found in wheat, rye and…”
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Enhanced CD8+ cytolytic T cell responses in the peripheral circulation of patients with sarcoidosis and non-Löfgren's disease by Parasa, Venkata Ramanarao, Forsslund, Helena, Enger, Tobias, Lorenz, Daniel, Kullberg, Susanna, Eklund, Anders, Sköld, Magnus, Wahlström, Jan, Grunewald, Johan, Brighenti, Susanna

“…The role of CD4+ T cells in the immunopathogenesis of pulmonary sarcoidosis is well-established, while less is known about the phenotype and function of CD8+…”
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Immune cell activation and cytokine release after stimulation of whole blood with pneumococcal C-polysaccharide and capsular polysaccharides by Sundberg-Kövamees, Marianne, Grunewald, Johan, Wahlström, Jan

“…Highlights • CWPS and the three pneumococcal capsular polysaccharides tested (type 3, type 9 and type 23) activated all leukocyte cell types tested but to…”
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T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis by Öckinger, Johan, Hagemann-Jensen, Michael, Kullberg, Susanna, Engvall, Benita, Eklund, Anders, Grunewald, Johan, Piehl, Fredrik, Olsson, Tomas, Wahlström, Jan

“…Abstract Cigarette smoking is a risk factor for multiple sclerosis (MS), and the risk is further multiplied for HLA-DRB1*15 + smokers. To define the…”
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Higher Monocyte Expression of TLR2 and TLR4, and Enhanced Pro-inflammatory Synergy of TLR2 with NOD2 Stimulation in Sarcoidosis by Wikén, Maria, Grunewald, Johan, Eklund, Anders, Wahlström, Jan

“…Introduction Sarcoidosis is an inflammatory disease of unknown etiology. However, an infectious cause has been proposed suggesting a role for…”
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Tolerability and efficacy of the monoaminergic stabilizer (-)-OSU6162 (PNU-96391A) in Huntington's disease: a double-blind cross-over study by Kloberg, Angelica, Constantinescu, Radu, Nilsson, Marie Karin Lena, Carlsson, Maria Lizzie, Carlsson, Arvid, Wahlström, Jan, Haghighi, Sara

“…To evaluate the safety (primary objective) and efficacy (secondary objective) of (-)-OSU6162 in Huntington's disease (HD). In a double-blind, cross-over trial,…”
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Autosomal Dominant Myopathy: Missense Mutation (Gly-706 → Lys) in the Myosin Heavy Chain IIa Gene by Martinsson, T, Oldfors, A, Darin, N, Berg, K, Tajsharghi, H, Kyllerman, M, Wahlstrom, J

“…We here report on a human myopathy associated with a mutation in a fast myosin heavy chain (MyHC) gene, and also the genetic defect in a hereditary inclusion…”
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Meta-analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling by Upreti, Vijay V., Wahlstrom, Jan L.

“…The accurate prediction of pharmacokinetics (PK) is fundamental to underwriting safety and efficacy in pediatric clinical trials; age‐dependent PK may be…”
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Analysis of Chromosome 5q31–32 and Psoriasis: Confirmation of a Susceptibility Locus but no Association with SNPs within SLC22A4 and SLC22A5 by Friberg, Camilla, Björck, Karin, Nilsson, Staffan, Inerot, Annica, Wahlström, Jan, Samuelsson, Lena

“…We have previously reported a region on chromosome 5q as a possible susceptibility region for psoriasis. This cytokine cluster-rich region has also been…”
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T cell receptor-Vβ repertoires in lung and blood CD4+ and CD8+ T cells of pulmonary sarcoidosis patients by Ahlgren, Kerstin M, Ruckdeschel, Tina, Eklund, Anders, Wahlström, Jan, Grunewald, Johan

“…Sarcoidosis patients have accumulations of activated CD4+ T cells in affected organs, such as the lungs. T cell receptor (TCR) Vβ-chain usage has been…”
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Familial Dyslexia in a Large Swedish Family: A Whole Genome Linkage Scan by Svensson, Idor, Nilsson, Staffan, Wahlström, Jan, Jernås, Margareta, Carlsson, Lena M., Hjelmquist, Erland

“…There is a compelling body of evidence that developmental dyslexia runs in families and seems to be highly inheritable. Several investigations during the last…”
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Absorption, Distribution, Metabolism, and Excretion of [ 14 C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism by Dahal, Upendra P, Rock, Brooke M, Rodgers, John, Shen, Xiaomeng, Wang, Zhe, Wahlstrom, Jan L

“…Sotorasib is a first-in-class, targeted covalent inhibitor of Kirsten rat sarcoma viral oncogene homolog (KRAS) approved by the FDA to treat patients with…”
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Association Between Genotypes and Phenotypes in Coeliac Disease by Gudjónsdóttir, Audur H, Nilsson, Staffan, Naluai, Åsa Torinsson, Ek, Johan, Amundsen, Silja S, Wahlström, Jan, Ascher, Henry

“…ABSTRACT Background: Coeliac disease (CD) is a genetically driven immunological intolerance to dietary gluten with a wide range of clinical presentations. The…”
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Genome-wide linkage scan for breast cancer susceptibility loci in Swedish hereditary non-BRCA1/2 families: Suggestive linkage to 10q23.32-q25.3 by Bergman, Annika, Karlsson, Per, Berggren, Jonna, Martinsson, Tommy, Björck, Karin, Nilsson, Staffan, Wahlström, Jan, Wallgren, Arne, Nordling, Margareta

“…The two breast cancer genes BRCA1 and BRCA2 were identified more than 10 years ago and, depending on population, mutations in these genes are responsible for a…”
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Distribution of T-Cell Subsets in BAL Fluid of Patients With Mild to Moderate COPD Depends on Current Smoking Status and Not Airway Obstruction by Forsslund, Helena, MSc, Mikko, Mikael, PhD, Karimi, Reza, MD, Grunewald, Johan, MD, PhD, Wheelock, Åsa M., PhD, Wahlström, Jan, PhD, Sköld, C. Magnus, MD, PhD

“…Background COPD is characterized by chronic inflammation. CD8+ T cells and CD4+ T cells have both been implicated in the inflammatory response. We investigated…”
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Selection of Alternative CYP3A4 Probe Substrates for Clinical Drug Interaction Studies Using In Vitro Data and In Vivo Simulation by FOTI, Robert S, ROCK, Dan A, WIENKERS, Larry C, WAHLSTROM, Jan L

“…Understanding the potential for cytochrome P450-mediated drug-drug interactions (DDIs) is a critical step in the drug discovery process. DDIs of CYP3A4 are of…”
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Searching for genes influencing a complex disease: the case of coeliac disease by NALUAI, Asa Torinsson, ASCHER, Henry, NILSSON, Staffan, WAHLSTRÖM, Jan

“…Recently, a few genes have been reported to be causative in inflammatory diseases. Still, we are waiting for the vast majority to be discovered. New tools for…”
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Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden by Enlund, F, Samuelsson, L, Enerbäck, C, Inerot, A, Wahlström, J, Yhr, M, Torinsson, A, Riley, J, Swanbeck, G, Martinsson, T

“…We have performed a pair-wise linkage study in the search for psoriasis susceptibility regions. A preliminary scan was performed on 20 families. In this set we…”
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