Search Results - "WAH CHIU"

Measurement of atom resolvability in cryo-EM maps with Q-scores by Pintilie, Grigore, Zhang, Kaiming, Su, Zhaoming, Li, Shanshan, Schmid, Michael F., Chiu, Wah

“…Cryogenic electron microscopy (cryo-EM) maps are now at the point where resolvability of individual atoms can be achieved. However, resolvability is not…”
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Designer nanoscale DNA assemblies programmed from the top down by Veneziano, Rémi, Ratanalert, Sakul, Zhang, Kaiming, Zhang, Fei, Yan, Hao, Chiu, Wah, Bathe, Mark

“…Scaffolded DNA origami is a versatile means of synthesizing complex molecular architectures. However, the approach is limited by the need to forward-design…”
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Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy by Guo, Sijin, Vieweger, Mario, Zhang, Kaiming, Yin, Hongran, Wang, Hongzhi, Li, Xin, Li, Shanshan, Hu, Shuiying, Sparreboom, Alex, Evers, B. Mark, Dong, Yizhou, Chiu, Wah, Guo, Peixuan

“…Paclitaxel is widely used in cancer treatments, but poor water-solubility and toxicity raise serious concerns. Here we report an RNA four-way junction…”
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Resolving individual atoms of protein complex by cryo-electron microscopy by Zhang, Kaiming, Pintilie, Grigore D., Li, Shanshan, Schmid, Michael F., Chiu, Wah

“…Breakthroughs in single-particle cryo-electron microscopy (cryo-EM) technology have made near-atomic resolution structure determination possible. Cryo-EM has…”
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An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump by Wang, Zhao, Fan, Guizhen, Hryc, Corey F, Blaza, James N, Serysheva, Irina I, Schmid, Michael F, Chiu, Wah, Luisi, Ben F, Du, Dijun

“…Bacterial efflux pumps confer multidrug resistance by transporting diverse antibiotics from the cell. In Gram-negative bacteria, some of these pumps form…”
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Assessment of structural features in Cryo-EM density maps using SSE and side chain Z-scores by Pintilie, Grigore, Chiu, Wah

“…We introduce a new method for assessing resolvability of structural features in density maps from Cryo-Electron Microscopy (Cryo-EM) using fitted or derived…”
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Capturing the swelling of solid-electrolyte interphase in lithium metal batteries by Zhang, Zewen, Li, Yuzhang, Xu, Rong, Zhou, Weijiang, Li, Yanbin, Oyakhire, Solomon T, Wu, Yecun, Xu, Jinwei, Wang, Hansen, Yu, Zhiao, Boyle, David T, Huang, William, Ye, Yusheng, Chen, Hao, Wan, Jiayu, Bao, Zhenan, Chiu, Wah, Cui, Yi

“…Although liquid-solid interfaces are foundational in broad areas of science, characterizing this delicate interface remains inherently difficult because of…”
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CryoEM reveals the stochastic nature of individual ATP binding events in a group II chaperonin by Zhao, Yanyan, Schmid, Michael F., Frydman, Judith, Chiu, Wah

“…Chaperonins are homo- or hetero-oligomeric complexes that use ATP binding and hydrolysis to facilitate protein folding. ATP hydrolysis exhibits both positive…”
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Convolutional neural networks for automated annotation of cellular cryo-electron tomograms by Chen, Muyuan, Dai, Wei, Sun, Stella Y, Jonasch, Darius, He, Cynthia Y, Schmid, Michael F, Chiu, Wah, Ludtke, Steven J

“…An algorithm and software tool automating the annotation of subcellular features in cryo-electron tomography data is presented. Cellular electron…”
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Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures by Kappel, Kalli, Zhang, Kaiming, Su, Zhaoming, Watkins, Andrew M., Kladwang, Wipapat, Li, Shanshan, Pintilie, Grigore, Topkar, Ved V., Rangan, Ramya, Zheludev, Ivan N., Yesselman, Joseph D., Chiu, Wah, Das, Rhiju

“…The discovery and design of biologically important RNA molecules is outpacing three-dimensional structural characterization. Here, we demonstrate that…”
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Structure of the AcrAB–TolC multidrug efflux pump by Du, Dijun, Wang, Zhao, James, Nathan R., Voss, Jarrod E., Klimont, Ewa, Ohene-Agyei, Thelma, Venter, Henrietta, Chiu, Wah, Luisi, Ben F.

“…Many bacteria are able to survive in the presence of antibiotics in part because they possess pumps that can remove a broad range of small molecules; here, the…”
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Emerging Roles of Calcium Signaling in the Development of Non-Alcoholic Fatty Liver Disease by Chen, Chien-Chih, Hsu, Li-Wen, Chen, Kuang-Den, Chiu, King-Wah, Chen, Chao-Long, Huang, Kuang-Tzu

“…The liver plays a central role in energy metabolism. Dysregulated hepatic lipid metabolism is a major cause of non-alcoholic fatty liver disease (NAFLD), a…”
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Decontamination of SARS-CoV‑2 and Other RNA Viruses from N95 Level Meltblown Polypropylene Fabric Using Heat under Different Humidities by Campos, Rafael K, Jin, Jing, Rafael, Grace H, Zhao, Mervin, Liao, Lei, Simmons, Graham, Chu, Steven, Weaver, Scott C, Chiu, Wah, Cui, Yi

“…In March of 2020, the World Health Organization declared a pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome…”
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Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution by Zhang, Kaiming, Li, Shanshan, Kappel, Kalli, Pintilie, Grigore, Su, Zhaoming, Mou, Tung-Chung, Schmid, Michael F., Das, Rhiju, Chiu, Wah

“…Specimens below 50 kDa have generally been considered too small to be analyzed by single-particle cryo-electron microscopy (cryo-EM). The high flexibility of…”
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Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome by Zhang, Kaiming, Zheludev, Ivan N., Hagey, Rachel J., Haslecker, Raphael, Hou, Yixuan J., Kretsch, Rachael, Pintilie, Grigore D., Rangan, Ramya, Kladwang, Wipapat, Li, Shanshan, Wu, Marie Teng-Pei, Pham, Edward A., Bernardin-Souibgui, Claire, Baric, Ralph S., Sheahan, Timothy P., D’Souza, Victoria, Glenn, Jeffrey S., Chiu, Wah, Das, Rhiju

“…Drug discovery campaigns against COVID-19 are beginning to target the SARS-CoV-2 RNA genome. The highly conserved frameshift stimulation element (FSE),…”
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Gating machinery of InsP3R channels revealed by electron cryomicroscopy by Fan, Guizhen, Baker, Matthew L., Wang, Zhao, Baker, Mariah R., Sinyagovskiy, Pavel A., Chiu, Wah, Ludtke, Steven J., Serysheva, Irina I.

“…Inositol-1,4,5-trisphosphate receptors (InsP 3 Rs) are ubiquitous ion channels responsible for cytosolic Ca 2+ signalling and essential for a broad array of…”
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Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy by Ranjbarvaziri, Sara, Kooiker, Kristina B., Ellenberger, Mathew, Fajardo, Giovanni, Zhao, Mingming, Vander Roest, Alison Schroer, Woldeyes, Rahel A., Koyano, Tiffany T., Fong, Robyn, Ma, Ning, Tian, Lei, Traber, Gavin M., Chan, Frandics, Perrino, John, Reddy, Sushma, Chiu, Wah, Wu, Joseph C., Woo, Joseph Y., Ruppel, Kathleen M., Spudich, James A., Snyder, Michael P., Contrepois, Kévin, Bernstein, Daniel

“…Hypertrophic cardiomyopathy (HCM) is a complex disease partly explained by the effects of individual gene variants on sarcomeric protein biomechanics. At the…”
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Full-length three-dimensional structure of the influenza A virus M1 protein and its organization into a matrix layer by Selzer, Lisa, Su, Zhaoming, Pintilie, Grigore D, Chiu, Wah, Kirkegaard, Karla

“…Matrix proteins are encoded by many enveloped viruses, including influenza viruses, herpes viruses, and coronaviruses. Underneath the viral envelope of…”
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Mapping the catalytic conformations of an assembly-line polyketide synthase module by Cogan, Dillon P, Zhang, Kaiming, Li, Xiuyuan, Li, Shanshan, Pintilie, Grigore D, Roh, Soung-Hun, Craik, Charles S, Chiu, Wah, Khosla, Chaitan

“…Assembly-line polyketide synthases, such as the 6-deoxyerythronolide B synthase (DEBS), are large enzyme factories prized for their ability to produce specific…”
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Cryo‐EM model validation using independent map reconstructions by DiMaio, Frank, Zhang, Junjie, Chiu, Wah, Baker, David

“…An increasing number of cryo‐electron microscopy (cryo‐EM) density maps are being generated with suitable resolution to trace the protein backbone and guide…”
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