Search Results - "WAGNER, Roland"

CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain by D'Osualdo, Andrea, Weichenberger, Christian X, Wagner, Roland N, Godzik, Adam, Wooley, John, Reed, John C

“…The "Function to Find Domain" (FIIND)-containing proteins CARD8 (Cardinal; Tucan) and NLRP1 (NALP1; NAC) are well known components of inflammasomes,…”
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Stop codon readthrough as a treatment option for epidermolysis bullosa—Where we are and where we are going by Zandanell, Johanna, Wießner, Michael, Bauer, Johann W., Wagner, Roland N.

“…In the context of rare genetic diseases caused by nonsense mutations, the concept of induced stop codon readthrough (SCR) represents an attractive avenue in…”
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Emerging Personalized Opportunities for Enhancing Translational Readthrough in Rare Genetic Diseases and Beyond by Wagner, Roland N, Wießner, Michael, Friedrich, Andreas, Zandanell, Johanna, Breitenbach-Koller, Hannelore, Bauer, Johann W

“…Nonsense mutations trigger premature translation termination and often give rise to prevalent and rare genetic diseases. Consequently, the pharmacological…”
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Evaluation of Nod-like receptor (NLR) effector domain interactions by Wagner, Roland N, Proell, Martina, Kufer, Thomas A, Schwarzenbacher, Robert

“…Members of the Nod-like receptor (NLR) family recognize intracellular pathogens and recruit a variety of effector molecules, including pro-caspases and…”
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Epigenetic and metabolic regulation of epidermal homeostasis by Wagner, Roland N., Piñón Hofbauer, Josefina, Wally, Verena, Kofler, Barbara, Schmuth, Matthias, De Rosa, Laura, De Luca, Michele, Bauer, Johann W.

“…Continuous exposure of the skin to environmental, mechanical and chemical stress necessitates constant self‐renewal of the epidermis to maintain its barrier…”
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HIV-1 protease cleaves the serine-threonine kinases RIPK1 and RIPK2 by Wagner, Roland N, Reed, John C, Chanda, Sumit K

“…HIV-1 protease (PR) is essential for viral infectivity as it cleaves Gag and Gag-Pol polyprotein precursors during viral maturation. Recent evidence suggests…”
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Improved Double-Nicking Strategies for COL7A1-Editing by Homologous Recombination by Kocher, Thomas, Wagner, Roland N., Klausegger, Alfred, Guttmann-Gruber, Christina, Hainzl, Stefan, Bauer, Johann W., Reichelt, Julia, Koller, Ulrich

“…Current gene-editing approaches for treatment of recessive dystrophic epidermolysis bullosa (RDEB), an inherited, severe form of blistering skin disease,…”
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Development of a Clonal and High-Yield Mammalian Cell Line for the Manufacturing of a Hyperactive Human DNase I with Extended Plasma Half-Life Using PASylation ® Technology by Stamm, Serge M, Wagner, Roland, Lang, Dietmar A, Skerra, Arne, Gebauer, Michaela

“…Cumulative evidence from several pre-clinical studies suggests that restoration of plasma DNase activity in a thrombo-inflammatory state may improve clinical…”
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Mutational analysis of human NOD1 and NOD2 NACHT domains reveals different modes of activation by Zurek, Birte, Proell, Martina, Wagner, Roland N, Schwarzenbacher, Robert, Kufer, Thomas A

“…Nucleotide-binding oligomerization domain-containing protein (NOD)1 and NOD2 are intracellular pattern recognition receptors (PRRs) of the nucleotide-binding…”
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Structural and Functional Analysis of the NLRP4 Pyrin Domain by Eibl, Clarissa, Grigoriu, Simina, Hessenberger, Manuel, Wenger, Julia, Puehringer, Sandra, Pinheiro, Anderson S, Wagner, Roland N, Proell, Martina, Reed, John C, Page, Rebecca, Diederichs, Kay, Peti, Wolfgang

“…NLRP4 is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family of cytosolic receptors and a member of an inflammation signaling…”
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Time-Resolved Monitoring of the Oxygen Transfer Rate of Chinese Hamster Ovary Cells Provides Insights Into Culture Behavior in Shake Flasks by Ihling, Nina, Munkler, Lara Pauline, Berg, Christoph, Reichenbächer, Britta, Wirth, Johannes, Lang, Dietmar, Wagner, Roland, Büchs, Jochen

“…Cultivations of mammalian cells are routinely conducted in shake flasks. In contrast to instrumented bioreactors, reliable options for non-invasive,…”
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Mercury's geochronology revised by applying Model Production Function to Mariner 10 data: Geological implications by Massironi, Matteo, Cremonese, Gabriele, Marchi, Simone, Martellato, Elena, Mottola, Stefano, Wagner, Roland J.

“…Model Production Function (MPF) chronology uses dynamic models of the Main Belt Asteroids (MBAs) and Near Earth Objects (NEOs) to derive the impactor flux to a…”
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Enceladus: An estimate of heat flux and lithospheric thickness from flexurally supported topography by Giese, Bernd, Wagner, Roland, Hussmann, Hauke, Neukum, Gerhard, Perry, Jason, Helfenstein, Paul, Thomas, Peter C.

“…We have identified flexural uplift along a rift zone of the Harran Sulci, Enceladus, using Cassini images and stereo‐derived topography. On the assumption that…”
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Asymmetric Craters on the Dwarf Planet Ceres—Results of Second Extended Mission Data Analysis by Krohn, Katrin, Jaumann, Ralf, Wickhusen, Kai, Otto, Katharina, Kersten, Elke, Stephan, Katrin, Wagner, Roland, Raymond, Carol, Russell, Christopher

“…After almost three years of successful operation on Ceres, the Dawn spacecraft entered its last orbits around the dwarf planet and obtained a set of…”
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Rift zone volcanism and associated cinder cone field in Utopia Planitia, Mars by Lanz, Julia K., Wagner, Roland, Wolf, Ursula, Kröchert, Jörg, Neukum, Gerhard

“…We analyzed a small cone field in SW Utopia Planitia that shows striking similarities to volcanic rift zones on Earth. This is of particular interest as the…”
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Tethys: Lithospheric thickness and heat flux from flexurally supported topography at Ithaca Chasma by Giese, Bernd, Wagner, Roland, Neukum, Gerhard, Helfenstein, Paul, Thomas, Peter C.

“…We have identified flexural uplift along the flanks of Tethys' Ithaca Chasma using Cassini stereo‐derived topography. Modeling the topography as a broken…”
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Guest Editorial: Advanced Technologies and Services for Multimedia Big Data Processing by Jeong, Young-Sik, Shyu, Mei-Ling, Xu, Guandong, Wagner, Roland R.

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Iapetus: Unique Surface Properties and a Global Color Dichotomy from Cassini Imaging by Denk, Tilmann, Neukum, Gerhard, Roatsch, Thomas, Porco, Carolyn C, Burns, Joseph A, Galuba, Götz G, Schmedemann, Nico, Helfenstein, Paul, Thomas, Peter C, Wagner, Roland J, West, Robert A

“…Since 2004, Saturn's moon Iapetus has been observed repeatedly with the Imaging Science Subsystem of the Cassini spacecraft. The images show numerous impact…”
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Animal Cell Biotechnology by Hansjörg Hauser, Roland Wagner, Hansjörg Hauser, Roland Wagner

“…This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell…”
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Evaluating thermal response tests using parameter estimation for thermal conductivity and thermal capacity by Wagner, Roland, Clauser, Christoph

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