Search Results - "WAGNER, Larry"
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A history of Wind Erosion Prediction Models in the United States Department of Agriculture: The Wind Erosion Prediction System (WEPS)
Published in Aeolian research (01-09-2013)“…Development of the Wind Erosion Prediction System (WEPS) was officially inaugurated in 1985 by United States Department of Agriculture-Agricultural Research…”
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Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
Published in Cell death and differentiation (01-04-2022)“…Anti-apoptotic Bcl-2-family members not only act at mitochondria but also at the endoplasmic reticulum, where they impact Ca 2+ dynamics by controlling IP 3…”
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The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING–p53 signaling
Published in Nature immunology (01-02-2022)“…The volume-regulated anion channel (VRAC) is formed by LRRC8 proteins and is responsible for the regulatory volume decrease (RVD) after hypotonic cell…”
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Evaluating the ability of the Wind Erosion Prediction System (WEPS) to simulate near-surface wind speeds in the Inland Pacific Northwest, USA
Published in Scientific reports (10-10-2024)“…Wind speed is one of the main control factors of wind erosion and dust emissions, which are major problems in arid and semiarid regions of the world…”
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Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms
Published in The Journal of clinical investigation (01-05-2022)“…As blood transitions from steady laminar flow (S-flow) in healthy arteries to disturbed flow (D-flow) in aneurysmal arteries, platelets are subjected to…”
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Differential regulation of the InsP3 receptor type‐1 and ‐2 single channel properties by InsP3, Ca2+ and ATP
Published in The Journal of physiology (01-07-2012)“…Key points • Three family members of inositol 1,4,5‐trisphosphate receptors (InsP3Rs) represent ubiquitously expressed intracellular Ca2+ release channels…”
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Bok regulates mitochondrial fusion and morphology
Published in Cell death and differentiation (01-12-2019)“…Bok (Bcl-2-related ovarian killer) is a member of the Bcl-2 protein family that governs the intrinsic apoptosis pathway, but the cellular role that Bok plays…”
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Ca2+ tunneling architecture and function are important for secretion
Published in The Journal of cell biology (06-01-2025)“…Ca2+ tunneling requires both store-operated Ca2+ entry (SOCE) and Ca2+ release from the endoplasmic reticulum (ER). Tunneling expands the SOCE microdomain…”
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MCMC Estimation of Markov Models for Ion Channels
Published in Biophysical journal (20-04-2011)“…Ion channels are characterized by inherently stochastic behavior which can be represented by continuous-time Markov models (CTMM). Although methods for…”
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Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors
Published in Proceedings of the National Academy of Sciences - PNAS (27-09-2022)“…Inositol 1,4,5-trisphosphate receptors (IP Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca )…”
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Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs
Published in The Journal of biological chemistry (04-03-2016)“…The ability of inositol 1,4,5-trisphosphate receptors (IP3R) to precisely initiate and generate a diverse variety of intracellular Ca2+ signals is in part…”
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Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function
Published in The Journal of clinical investigation (01-11-2016)“…Eccrine sweat glands are essential for sweating and thermoregulation in humans. Loss-of-function mutations in the Ca2+ release-activated Ca2+ (CRAC) channel…”
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Protein Kinase A Increases Type-2 Inositol 1,4,5-Trisphosphate Receptor Activity by Phosphorylation of Serine 937
Published in The Journal of biological chemistry (11-09-2009)“…Protein kinase A (PKA) phosphorylation of inositol 1,4,5-trisphosphate receptors (InsP3Rs) represents a mechanism for shaping intracellular Ca2+ signals…”
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Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity
Published in The Journal of biological chemistry (14-07-2017)“…The inositol 1,4,5 trisphosphate receptor (IP3R) is an intracellular Ca2+ release channel expressed predominately on the membranes of the endoplasmic…”
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IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin‐43 hemichannels
Published in Acta Physiologica (01-03-2024)“…Aim Inositol 1,4,5‐trisphosphate receptors (IP3Rs) are intracellular Ca2+‐release channels with crucial roles in cell function. Current IP3R inhibitors suffer…”
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Sex-Specific Platelet Activation Through Protease-Activated Receptors Reverses in Myocardial Infarction
Published in Arteriosclerosis, thrombosis, and vascular biology (01-01-2021)“…OBJECTIVE:The platelet phenotype in certain patients and clinical contexts may differ from healthy conditions. We evaluated platelet activation through…”
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Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes
Published in Nature communications (02-08-2022)“…Two-pore channels are endo-lysosomal cation channels with malleable selectivity filters that drive endocytic ion flux and membrane traffic. Here we show that…”
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The BRCA1 Tumor Suppressor Binds to Inositol 1,4,5-Trisphosphate Receptors to Stimulate Apoptotic Calcium Release
Published in The Journal of biological chemistry (13-03-2015)“…The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitously expressed endoplasmic reticulum (ER)-resident calcium channel. Calcium release mediated by…”
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Akt Kinase Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors
Published in The Journal of biological chemistry (10-02-2006)“…A consensus RXRXX(S/T) substrate motif for Akt kinase is conserved in the C-terminal tail of all three inositol 1,4,5-trisphosphate (IP3) receptor (IP3R)…”
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CREB regulates the expression of type 1 inositol 1,4,5-trisphosphate receptors
Published in Journal of cell science (15-10-2021)“…Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) play a central role in regulating intracellular Ca2+ signals in response to a variety of internal and…”
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