Search Results - "WAGNER, Klaus"
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Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans
Published in PLoS medicine (01-11-2014)“…FK506 binding protein 51 (FKBP51) is an Hsp90 co-chaperone and regulator of the glucocorticoid receptor, and consequently of stress physiology. Clinical…”
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Frequency and Type of Situational Awareness Errors Contributing to Death and Brain Damage: A Closed Claims Analysis
Published in Anesthesiology (Philadelphia) (01-08-2017)“…Situational awareness errors may play an important role in the genesis of patient harm. The authors examined closed anesthesia malpractice claims for death or…”
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Situation Awareness in Anesthesia: Concept and Research
Published in Anesthesiology (Philadelphia) (01-03-2013)“…Accurate situation awareness (SA) of medical staff is integral for providing optimal performance during the treatment of patients. An understanding of SA and…”
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Regulation of the macrophage oxytocin receptor in response to inflammation
Published in American journal of physiology: endocrinology and metabolism (01-03-2017)“…It has been demonstrated that the neuropeptide oxytocin (OT) attenuates oxidative stress and inflammation in macrophages. In the current study, we examined the…”
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5
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
Published in Nature medicine (01-09-2007)“…Apo2L/TRAIL stimulates cancer cell death through the proapoptotic receptors DR4 and DR5, but the determinants of tumor susceptibility to this ligand are not…”
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Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss
Published in Nature neuroscience (01-06-2013)“…Early-life stress, acting through corticotrophin-releasing hormone (CRH) and its receptor CRHR1, can have long-lasting effects on animals' behavior. Nectin-3…”
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Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity
Published in PLoS biology (28-12-2017)“…Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currently, leading to uncertainty in medication selection,…”
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Depletion of FKBP51 in female mice shapes HPA axis activity
Published in PloS one (01-04-2014)“…Psychiatric disorders such as depressive disorders and posttraumatic stress disorder are a major disease burden worldwide and have a higher incidence in women…”
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Transcriptional Repression of Histone Deacetylase 3 by the Histone Demethylase KDM2A Is Coupled to Tumorigenicity of Lung Cancer Cells
Published in The Journal of biological chemistry (14-03-2014)“…Dysregulated expression of histone methyltransferases and demethylases is an emerging epigenetic mechanism underlying cancer development and metastasis. We…”
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10
Evidence supporting the match/mismatch hypothesis of psychiatric disorders
Published in European neuropsychopharmacology (01-06-2014)“…Abstract Chronic stress is one of the predominant environmental risk factors for a number of psychiatric disorders, particularly for major depression…”
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The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress
Published in Neuropharmacology (01-01-2012)“…Chronic stress is increasingly considered to be a main risk factor for the development of a variety of psychiatric diseases such as depression. This is further…”
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Interplay between diet-induced obesity and chronic stress in mice: potential role of FKBP51
Published in Journal of endocrinology (01-07-2014)“…While it is known that stress promotes obesity, the effects of stress within an obesogenic context are not so clear and molecular targets at the interface…”
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13
Situation awareness errors in anesthesia and critical care in 200 cases of a critical incident reporting system
Published in BMC anesthesiology (16-01-2016)“…A loss of adequate Situation Awareness (SA) may play a major role in the genesis of critical incidents in anesthesia and critical care. This observational…”
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The Metabolism and Disposition of the Oral Dipeptidyl Peptidase-4 Inhibitor, Linagliptin, in Humans
Published in Drug metabolism and disposition (01-04-2010)“…The pharmacokinetics and metabolism of linagliptin (BI1356,…”
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Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling
Published in Neurobiology of disease (01-06-2011)“…Abstract Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underlie spatial memory deficits…”
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The Runner's High: Opioidergic Mechanisms in the Human Brain
Published in Cerebral cortex (New York, N.Y. 1991) (01-11-2008)“…The runner's high describes a euphoric state resulting from long-distance running. The cerebral neurochemical correlates of exercise-induced mood changes have…”
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Development of a 13C NMR Chemical Shift Prediction Procedure Using B3LYP/cc-pVDZ and Empirically Derived Systematic Error Correction Terms: A Computational Small Molecule Structure Elucidation Method
Published in Journal of organic chemistry (19-05-2017)“…An accurate and efficient procedure was developed for performing 13C NMR chemical shift calculations employing density functional theory with the gauge…”
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Land Use in Flood-Prone Areas and Its Significance for Flood Risk Management—A Case Study of Alpine Regions in Austria
Published in Land (Basel) (01-03-2022)“…Increasing flood damage has led to a rising importance of land use in flood risk management policies, commonly referred to as the spatial turn in flood risk…”
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Opioid-Induced Nausea Involves a Vestibular Problem Preventable by Head-Rest
Published in PloS one (27-08-2015)“…Opioids are indispensable for pain treatment but may cause serious nausea and vomiting. The mechanism leading to these complications is not clear. We…”
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Preventing opioid-induced nausea and vomiting: Rest your head and close your eyes?
Published in PloS one (14-03-2017)“…Although opioid-induced nausea and vomiting (OINV) is common and debilitating, its mechanism is still unclear. Recently, we suggested that opioids affect…”
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