Search Results - "WAGNER, Alan C"

A novel approach to oral apoA-I mimetic therapy[S] by Chattopadhyay, Arnab, Navab, Mohamad, Hough, Greg, Gao, Feng, Meriwether, David, Grijalva, Victor, Springstead, James R., Palgnachari, Mayakonda N., Namiri-Kalantari, Ryan, Su, Feng, Van Lenten, Brian J., Wagner, Alan C., Anantharamaiah, G.M., Farias-Eisner, Robin, Reddy, Srinivasa T., Fogelman, Alan M.

“…Transgenic tomato plants were constructed with an empty vector (EV) or a vector expressing an apoA-I mimetic peptide, 6F. EV or 6F tomatoes were harvested,…”
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Anti-inflammatory apoA-I-mimetic peptides bind oxidized lipids with much higher affinity than human apoA-I by Van Lenten, Brian J., Wagner, Alan C., Jung, Chun-Ling, Ruchala, Piotr, Waring, Alan J., Lehrer, Robert I., Watson, Andrew D., Hama, Susan, Navab, Mohamad, Anantharamaiah, G.M., Fogelman, Alan M.

“…4F is an anti-inflammatory, apolipoprotein A-I (apoA-I)-mimetic peptide that is active in vivo at nanomolar concentrations in the presence of a large molar…”
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Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis by Navab, Mohamad, Chattopadhyay, Arnab, Hough, Greg, Meriwether, David, Fogelman, Spencer I., Wagner, Alan C., Grijalva, Victor, Su, Feng, Anantharamaiah, G.M., Hwang, Lin H., Faull, Kym F., Reddy, Srinivasa T., Fogelman, Alan M.

“…We previously reported that i) a Western diet increased levels of unsaturated lysophosphatidic acid (LPA) in small intestine and plasma of LDL receptor null…”
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Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid[S] by Navab, Mohamad, Hough, Greg, Buga, Georgette M., Su, Feng, Wagner, Alan C., Meriwether, David, Chattopadhyay, Arnab, Gao, Feng, Grijalva, Victor, Danciger, Janet S., Van Lenten, Brian J., Org, Elin, Lusis, Aldons J., Pan, Calvin, Anantharamaiah, G.M., Farias-Eisner, Robin, Smyth, Susan S., Reddy, Srinivasa T., Fogelman, Alan M.

“…We recently reported that levels of unsaturated lysophosphatidic acid (LPA) in the small intestine significantly correlated with the extent of aortic…”
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Lipoprotein inflammatory properties and serum amyloid A levels but not cholesterol levels predict lesion area in cholesterol-fed rabbits by Van Lenten, Brian J., Wagner, Alan C., Navab, Mohamad, Anantharamaiah, G.M., Hama, Susan, Reddy, Srinivasa T., Fogelman, Alan M.

“…Rabbits on a 1% cholesterol diet received injections of vehicle with or without D-4F or L-4F. After 1 month, the percent of aorta with atherosclerotic lesions…”
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High-density lipoprotein loses its anti-inflammatory properties during acute Influenza A infection by VAN LENTEN, Brian J, WAGNER, Alan C, NAYAK, Debi P, HAMA, Susan, NAVAB, Mohamad, FOGELMAN, Alan M

“…Viruses have been identified as one of a variety of potential agents that are implicated in atherogenesis. C57BL/6J mice were killed before or 2, 3, 5, 7, or 9…”
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An Oral ApoJ Peptide Renders HDL Antiinflammatory in Mice and Monkeys and Dramatically Reduces Atherosclerosis in Apolipoprotein E–Null Mice by Navab, Mohamad, Anantharamaiah, G M, Reddy, Srinivasa T, Van Lenten, Brian J, Wagner, Alan C, Hama, Susan, Bachini, Greg Hough Eugene, Garber, David W, Mishra, Vinod K, Palgunachari, Mayakonda N, Fogelman, Alan M

“…OBJECTIVE—To determine the properties of a peptide synthesized from D-amino acids corresponding to residues 113 to 122 in apolipoprotein (apo) J. METHODS AND…”
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L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL in mice by Imaizumi, Satoshi, Grijalva, Victor, Navab, Mohamad, Van Lenten, Brian J, Wagner, Alan C, Anantharamiah, G M, Fogelman, Alan M, Reddy, Srinivasa T

“…To determine in vivo if L-4F differentially alters plasma levels of oxidized fatty acids resulting in more anti-inflammatory HDL. Injecting L-4F into apoE null…”
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High-Density Lipoprotein and 4F Peptide Reduce Systemic Inflammation by Modulating Intestinal Oxidized Lipid Metabolism: Novel Hypotheses and Review of Literature by Navab, Mohamad, Reddy, Srinivasa T, Van Lenten, Brian J, Buga, Georgette M, Hough, Greg, Wagner, Alan C, Fogelman, Alan M

“…Oxidized phospholipids are found in the vasculature of animal models of atherosclerosis, in human atherosclerotic lesions, and in other inflammatory diseases…”
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Oral D-4F causes formation of pre-β high-density lipoprotein and improves high-density lipoprotein-mediated cholesterol efflux and reverse cholesterol transport from macrophages in apolipoprotein E-null mice by NAVAB, Mohamad, ANANTHARAMAIAH, G. M, FOGELMAN, Alan M, REDDY, Srinivasa T, HAMA, Susan, HOUGH, Greg, GRIJALVA, Victor R, WAGNER, Alan C, FRANK, Joy S, DATTA, Geeta, GARBER, David

“…These studies were designed to determine the mechanism of action of an oral apolipoprotein (apo) A-I mimetic peptide, D-4F, which previously was shown to…”
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Apolipoprotein A-I mimetic peptides by Van Lenten, Brian J., Wagner, Alan C., Anantharamaiah, G. M., Navab, Mohamad, Reddy, Srinivasa T., Buga, Georgette M., Fogelman, Alan M.

“…Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids…”
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D-4F, an apolipoprotein A-I mimetic peptide, inhibits the inflammatory response induced by influenza A infection of human type II pneumocytes by Van Lenten, Brian J, Wagner, Alan C, Navab, Mohamad, Anantharamaiah, G M, Hui, Eric Ka-Wai, Nayak, Debi P, Fogelman, Alan M

“…Evidence suggests that apolipoprotein A-I (apoA-I) and HDL play important roles in modulating inflammation. We previously reported that an apoA-I mimetic…”
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Influenza infection promotes macrophage traffic into arteries of mice that is prevented by D-4F, an apolipoprotein A-I mimetic peptide by VAN LENTEN, Brian J, WAGNER, Alan C, ANANTHARAMAIAH, G. M, GARBER, David W, FISHBEIN, Michael C, ADHIKARY, Lopa, NAYAK, Debi P, HAMA, Susan, NAVAB, Mohamad, FOGELMAN, Alan M

“…We reported that HDL loses its antiinflammatory properties during acute influenza A infection in mice, and we hypothesized that these changes might be…”
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The double jeopardy of HDL by Navab, Mohamad, Ananthramaiah, G M, Reddy, Srinivasa T, Van Lenten, Brian J, Ansell, Benjamin J, Hama, Susan, Hough, Greg, Bachini, Eugene, Grijalva, Victor R, Wagner, Alan C, Shaposhnik, Zory, Fogelman, Alan M

“…The ability of high-density lipoprotein (HDL) to promote cholesterol efflux is thought to be important in its protection against cardiovascular disease…”
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Treatment with an apolipoprotein A-1 mimetic peptide in combination with pravastatin inhibits collagen-induced arthritis by Charles-Schoeman, Christina, Banquerigo, Mona Lisa, Hama, Susan, Navab, Mohamad, Park, Grace S, Van Lenten, Brian J, Wagner, Alan C, Fogelman, Alan M, Brahn, Ernest

“…Abstract To evaluate the therapeutic potential of an apolipoprotein A-1 (apoA-1) mimetic peptide, D-4F, in combination with pravastatin in collagen-induced…”
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Oxidized Phospholipids Induce Changes in Hepatic Paraoxonase and ApoJ but Not Monocyte Chemoattractant Protein-1 via Interleukin-6 by Van Lenten, Brian J., Wagner, Alan C., Navab, Mohamad, Fogelman, Alan M.

“…In this study, we tested if interleukin-6 (IL-6) plays a role in mediating the effects of oxidized phospholipids (OXPL). Treatment of HepG2 cells with oxidized…”
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Abstract 9179: Free Oxidized Fatty Acids Contribute to Pro-Inflammatory HDL by Van Lenten, Brian J, Wagner, Alan C, Reddy, Srinivasa T, Navab, Mohamad, Fogelman, Alan M

“…Abstract only Background: Based on previous studies we thought it likely that the content of oxidized phospholipids would be elevated in pro-inflammatory HDL…”
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