Search Results - "WAGENFELD, Andrea"

Selective progesterone receptor modulators (SPRMs): progesterone receptor action, mode of action on the endometrium and treatment options in gynecological therapies by Wagenfeld, Andrea, Saunders, Philippa T K, Whitaker, Lucy, Critchley, Hilary O D

“…The progesterone receptor plays an essential role in uterine physiology and reproduction. Selective progesterone receptor modulators (SPRMs) have emerged as a…”
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Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies by Möller, Carsten, Bone, Wilhelm, Cleve, Arwed, Klar, Ulrich, Rotgeri, Andrea, Rottmann, Antje, Schultze‐Mosgau, Marcus‐Hillert, Wagenfeld, Andrea, Schwede, Wolfgang

“…Progesterone plays an important role in the female reproductive system. However, there is also evidence that gynecologic disorders/diseases such as uterine…”
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The oral IRAK4 inhibitors zabedosertib and BAY1830839 suppress local and systemic immune responses in a randomized trial in healthy male volunteers by Jodl, Stefan J., Voorde, Wouter, Klein, Stefan, Wagenfeld, Andrea, Zollmann, Frank S., Feldmüller, Maximilian, Klarenbeek, Naomi B., Bruin, Digna T., Jansen, Manon A. A., Rissmann, Robert, Rohde, Beate, Moerland, Matthijs

“…This study evaluated and characterized the pharmacological activity of the orally administered interleukin‐1 receptor‐associated kinase 4 (IRAK4) inhibitors…”
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Sperm Volume Regulation: Maturational Changes in Fertile and Infertile Transgenic Mice and Association with Kinematics and Tail Angulation by YEUNG, Ching-Hei, ANAPOLSKI, Michael, SIPILÄ, Petra, WAGENFELD, Andrea, POUTANEN, Matti, HUHTANIEMI, Ilpo, NIESCHLAG, Eberhard, COOPER, Trevor G

“…Laser light scatter analyzed by flow cytometry was used to monitor the volume of viable maturing murine spermatozoa. Upon release, dispersion, and dilution,…”
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Molecular Cloning and Expression of Rat Contraception Associated Protein 1 (CAP1), a Protein Putatively Involved in Fertilization by Wagenfeld, Andrea, Gromoll, Jörg, Cooper, Trevor G.

“…Epididymal fluid from rats rendered infertile by oral administration of ornidazole contains a protein CAP1 (contraception-associated protein 1) that is absent…”
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Gene and Protein Expression in the Epididymis of Infertile c-ros Receptor Tyrosine Kinase-Deficient Mice by COOPER, Trevor G, WAGENFELD, Andrea, YEUNG, Ching-Hei, CORNWALL, Gail A, HSIA, Nelson, SIN TAK CHU, ORGEBIN-CRIST, Marie-Claire, DREVET, Joel, VERNET, Patrick, AVRAM, Cosmina, NIESCHLAG, Eberhard

“…Transgenic male mice bearing inactive mutations of the receptor tyrosine kinase c- ros lack the initial segment of the epididymis and are infertile. Several…”
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Sodium-Inorganic Phosphate Cotransporter NaPi-IIb in the Epididymis and Its Potential Role in Male Fertility Studied in a Transgenic Mouse Model by YAOXIAN XU, YEUNG, Ching-Hei, SETIAWAN, Iwan, AVRAM, Cosmina, BIBER, Jürg, WAGENFELD, Andrea, LANG, Florian, COOPER, Trevor G

“…Analysis by cDNA microarrays showed that in the murine epididymis, NaP i -IIb was the predominantly expressed epithelial isoform of the sodium-inorganic…”
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Gene and Protein Expression in the Epididymis of Infertile c-ros Receptor Tyrosine Kinase-Deficient Mice1 by Cooper, Trevor G, Wagenfeld, Andrea, Cornwall, Gail A, Hsia, Nelson, Chu, Sin Tak, Orgebin-Crist, Marie-Claire, Drevet, Joel, Vernet, Patrick, Avram, Cosmina, Nieschlag, Eberhard, Yeung, Ching-Hei

“…Transgenic male mice bearing inactive mutations of the receptor tyrosine kinase c-ros lack the initial segment of the epididymis and are infertile. Several…”
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Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women by Panknin, Olaf, Wagenfeld, Andrea, Bone, Wilhelm, Bender, Eckhard, Nowak-Reppel, Katrin, Fernández-Montalván, Amaury E, Nubbemeyer, Reinhard, Bäurle, Stefan, Ring, Sven, Schmees, Norbert, Prien, Olaf, Schäfer, Martina, Friedrich, Christian, Zollner, Thomas M, Steinmeyer, Andreas, Mueller, Thomas, Langer, Gernot

“…The growth of uterine fibroids is sex hormone-dependent and commonly associated with highly incapacitating symptoms. Most treatment options consist of the…”
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The Cause of Infertility of Male c-ros Tyrosine Kinase Receptor Knockout Mice1 by Yeung, Ching-Hei, Wagenfeld, Andrea, Nieschlag, Eberhard, Cooper, Trevor G

“…Male homozygous transgenic c-ros knockout mice are sterile by natural mating, lack a part of their epididymis, and the epididymal sperm exhibit tail angulation…”
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Front Cover: Discovery of Vilaprisan (BAY 1002670): A Highly Potent and Selective Progesterone Receptor Modulator Optimized for Gynecologic Therapies (ChemMedChem 21/2018) by Möller, Carsten, Bone, Wilhelm, Cleve, Arwed, Klar, Ulrich, Rotgeri, Andrea, Rottmann, Antje, Schultze‐Mosgau, Marcus‐Hillert, Wagenfeld, Andrea, Schwede, Wolfgang

“…The Front Cover shows vilaprisan, a highly selective progesterone receptor modulator (SPRM), bound to the progesterone receptor (PR). Gynecologic diseases such…”
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Expression and Cellular Localization of Contraception‐Associated Protein 1 by WAGENFELD, ANDREA, YEUNG, CHING‐HEI, SHIVAJI, SISINTHI, SUNDARESWARAN, VETAIKORUMAGAN R., ARIGA, HIROYOSHI, COOPER, TREVOR G.

“…Treatment of male rats with ornidazole results in reversible infertility, which is associated with the detection of the contraception‐associated protein 1…”
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BAY 1002670: a novel, highly potent and selective progesterone receptor modulator for gynaecological therapies by Wagenfeld, Andrea, Bone, Wilhelm, Schwede, Wolfgang, Fritsch, Martin, Fischer, Oliver M., Moeller, Carsten

“…STUDY QUESTION Does the novel progesterone receptor (PR) modulator BAY 1002670, based on its preclinical pharmacological profile, offer a potential novel…”
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Inhibition of Proliferation and Fibrosis by Vitamin D Agonists—Impact for Uterine Leiomyoma by Wagenfeld, Andrea, Moeller, Carsten, Sandner, Peter, Schwede, Wolfgang, Steinmeyer, Andreas, Zuegel, Ulrich

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Transcriptional Profiling of the Hormone-Responsive Stages of Spermatogenesis Reveals Cell-, Stage-, and Hormone-Specific Events by O'Donnell, Liza, Pratis, Kyriakos, Wagenfeld, Andrea, Gottwald, Ulrich, Müller, Jörg, Leder, Gabriele, McLachlan, Robert I, Stanton, Peter G

“…Spermatogenesis occurs within the highly complex seminiferous epithelium. This cyclic process is accompanied by dynamic stage-specific transcriptional changes…”
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Mouse models of infertility due to swollen spermatozoa by Cooper, Trevor G, Yeung, Ching-Hei, Wagenfeld, Andrea, Nieschlag, Eberhard, Poutanen, Matti, Huhtaniemi, Ilpo, Sipilä, Petra

“…Transgenic mice with male infertility, the c- ros knockout (KO) and GPX5-Tag2 transgenic mouse models, are compared. Both exhibit severely angulated sperm…”
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The Cause of Infertility of Male c-ros Tyrosine Kinase Receptor Knockout Mice by YEUNG, C.-H, WAGENFELD, A, NIESCHLAG, E, COOPER, T. G

“…Male homozygous transgenic c- ros knockout mice are sterile by natural mating, lack a part of their epididymis, and the epididymal sperm exhibit tail…”
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Sodium-Inorganic Phosphate Cotransporter NaPi-IIb in the Epididymis and Its Potential Role in Male Fertility Studied in a Transgenic Mouse Model1 by Xu, Yaoxian, Yeung, Ching-Hei, Setiawan, Iwan, Avram, Cosmina, Biber, Jürg, Wagenfeld, Andrea, Lang, Florian, Cooper, Trevor G

“…Analysis by cDNA microarrays showed that in the murine epididymis, NaPi-IIb was the predominantly expressed epithelial isoform of the sodium-inorganic…”
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Male contraception—a topic with many facets by John Lye, R, Sipilä, Petra, Vernet, Patrick, Wagenfeld, Andrea

“…In addition to the scientific issues associated with male contraception, there are a variety of other concerns that must be addressed before new male…”
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Shedding of a rat epididymal sperm protein associated with infertility induced by ornidazole and alpha-chlorohydrin by WAGENFELD, A, YEUNG, C.-H, STRUPAT, K, COOPER, T. G

“…The protein composition of epididymal fluid and sperm extracts of rats treated with the nitroimidazole compound ornidazole was investigated by two-dimensional…”
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