Search Results - "WAELKENS, E."

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice by Lemaire, K, Ravier, M.A, Schraenen, A, Creemers, J.W.M, Van de Plas, R, Granvik, M, Van Lommel, L, Waelkens, E, Chimienti, F, Rutter, G.A, Gilon, P, Veld, P.A. in't, Schuit, F.C

“…Zinc co-crystallizes with insulin in dense core secretory granules, but its role in insulin biosynthesis, storage and secretion is unknown. In this study we…”
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Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis by Vodolazkaia, A., El-Aalamat, Y., Popovic, D., Mihalyi, A., Bossuyt, X., Kyama, C.M., Fassbender, A., Bokor, A., Schols, D., Huskens, D., Meuleman, C., Peeraer, K., Tomassetti, C., Gevaert, O., Waelkens, E., Kasran, A., De Moor, B., D'Hooghe, T.M.

“…Background At present, the only way to conclusively diagnose endometriosis is laparoscopic inspection, preferably with histological confirmation. This…”
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Sequencing refractory regions in bird genomes are hotspots for accelerated protein evolution by Huttener, R, Thorrez, L, Veld, T. In't, Granvik, M, Van Lommel, L, Waelkens, E, Derua, R, Lemaire, K, Goyvaerts, L, De Coster, S, Buyse, J, Schuit, F

“…Abstract Background Approximately 1000 protein encoding genes common for vertebrates are still unannotated in avian genomes. Are these genes evolutionary lost…”
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Combined mRNA microarray and proteomic analysis of eutopic endometrium of women with and without endometriosis by Fassbender, A., Verbeeck, N., Börnigen, D., Kyama, C.M., Bokor, A., Vodolazkaia, A., Peeraer, K., Tomassetti, C., Meuleman, C., Gevaert, O., Van de Plas, R., Ojeda, F., De Moor, B., Moreau, Y., Waelkens, E., D'Hooghe, T.M.

“…BACKGROUND An early semi-invasive diagnosis of endometriosis has the potential to allow early treatment and minimize disease progression but no such test is…”
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An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis by Lara, R, Mauri, F A, Taylor, H, Derua, R, Shia, A, Gray, C, Nicols, A, Shiner, R J, Schofield, E, Bates, P A, Waelkens, E, Dallman, M, Lamb, J, Zicha, D, Downward, J, Seckl, M J, Pardo, O E

“…We performed a kinome-wide siRNA screen and identified 70 kinases altering cell migration in A549 lung cancer cells. In particular, ribosomal S6 kinase 1…”
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Discovery of endometriosis biomarkers in menstrual plasma samples using a proteomics approach by O, D, Waelkens, E, Peterse, D.P, Vanhie, A, Meuleman, C, D'Hooghe, T, Fassbender, A

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The metabolic response of cultured tomato cells to low oxygen stress by Ampofo-Asiama, J., Baiye, V. M. M., Hertog, M. L. A. T. M., Waelkens, E., Geeraerd, A. H., Nicolai, B. M.

“…The storage of fruits and vegetables under a controlled atmosphere can induce low oxygen stress, which can lead to post-harvest losses through the induction of…”
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The lectin‐like domain of thrombomodulin interferes with complement activation and protects against arthritis by VAN DE WOUWER, M., PLAISANCE, S., DE VRIESE, A., WAELKENS, E., COLLEN, D., PERSSON, J., DAHA, M. R., CONWAY, E. M.

“…Background: Thrombomodulin (TM) is predominantly a vascular endothelial cell plasma membrane glycoprotein that, via distinct structural domains, interacts with…”
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Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons by Morawski, M, Nuytens, K, Juhasz, T, Zeitschel, U, Seeger, G, Waelkens, E, Regal, L, Schulz, I, Arendt, T, Szeltner, Z, Creemers, J, Roßner, S

“…Graphical abstract Highlights ► PREPL deficiency affects the abundance of cytoskeletal proteins. ► PREPL is co-localized with cytoskeletal proteins in mouse…”
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Platelet Gs hypofunction and abnormal morphology resulting from a heterozygous RGS2 mutation by NOÉ, L., DI MICHELE, M., GIETS, E., THYS, C., WITTEVRONGEL, C., DE VOS, R., OVERBERGH, L., WAELKENS, E., JAEKEN, J., VAN GEET, C., FRESON, K.

“…Background: Regulator of G‐protein signaling (RGS) 2 negatively regulates Gs signaling by inhibiting the activation of adenylyl cyclase (AC). RGS2 mRNA…”
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A proteomic approach on the effects of TX527, a 1α,25-dihydroxyvitamin D3 analog, in human T lymphocytes by Ferreira, G.B., Baeke, F., Verstuyf, A., De Clercq, P., Waelkens, E., Mathieu, C., Overbergh, L.

“…•TX527, a 1α,25(OH)2D3 analog, alters the global protein profile of human T cells.•TX527 affects proteins involved in energy/protein metabolism and…”
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Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype by SWINNEN, Johannes V, BECKERS, Annelies, DE SCHRIJVER, Ellen, VAN DE SANDE, Tine, NOËL, Agnès, FOUFELLE, Fabienne, VERHOEVEN, Guido, BRUSSELMANS, Koen, ORGANE, Sophie, SEGERS, Joanna, TIMMERMANS, Leen, VANDERHOYDONC, Frank, DEBOEL, Ludo, DERUA, Rita, WAELKENS, Etienne

“…Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took…”
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Purification of Porcine Brain Protein Phosphatase 2A Leucine Carboxyl Methyltransferase and Cloning of the Human Homologue by De Baere, I, Derua, R, Janssens, V, Van Hoof, C, Waelkens, E, Merlevede, W, Goris, J

“…The carboxyl methyltransferase, which is claimed to exclusively methylate the carboxyl group of the C-terminal leucine residue of the catalytic subunit of…”
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Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: A key to study an angiogenic marker in vivo? by Wynendaele, W., Derua, R., Hoylaerts, M. F., Pawinski, A., Waelkens, E., de Bruijn, E. A., Paridaens, R., Merlevede, W., van Oosterom, A. T.

“…Background: Serum VEGF levels are elevated in cancer patients and are used as a tumor marker in different malignancies. We have measured VEGF levels in…”
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Metabolic profiling of the response of tomato cells to oxygen stress by Ampofo-Asiama, J, Hertog, M.L.A.T.M, Geeraerd, A.H, Nicolaï, B.M, Waelkens, E

“…To cope with postharvest storage under controlled atmosphere (CA) conditions, plant metabolism must be able to adapt to varying levels of oxygen, carbon…”
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Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A by Cayla, X, Van Hoof, C, Bosch, M, Waelkens, E, Vandekerckhove, J, Peeters, B, Merlevede, W, Goris, J

“…PTPA, or phosphotyrosyl phosphatase activator, is a protein that stimulates the tyrosyl phosphatase activity of protein phosphatase 2A in an ATP,…”
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Biomarkers of endometriosis by Fassbender, Amelie, Ph.D, Vodolazkaia, Alexandra, Ph.D., M.D, Saunders, Philippa, Ph.D, Lebovic, Dan, M.D, Waelkens, Etienne, Ph.D., M.D, De Moor, Bart, Ph.D, D'Hooghe, Thomas, Ph.D., M.D

“…A noninvasive test for endometriosis would be useful for the early detection of endometriosis in symptomatic women who have pelvic pain and/or subfertility…”
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Non‐small cell lung cancer is characterized by dramatic changes in phospholipid profiles by Marien, Eyra, Meister, Michael, Muley, Thomas, Fieuws, Steffen, Bordel, Sergio, Derua, Rita, Spraggins, Jeffrey, Van de Plas, Raf, Dehairs, Jonas, Wouters, Jens, Bagadi, Muralidhararao, Dienemann, Hendrik, Thomas, Michael, Schnabel, Philipp A., Caprioli, Richard M., Waelkens, Etienne, Swinnen, Johannes V.

“…Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death globally. To develop better diagnostics and more effective treatments, research in the…”
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Purification and properties of polycation-stimulated phosphorylase phosphatases from rabbit skeletal muscle by Waelkens, E, Goris, J, Merlevede, W

“…Four types of polycation-stimulated (PCS) phosphorylase phosphatases have been isolated from rabbit skeletal muscle. They are called PCSH (390 kDa), PCSM (250…”
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In Vitro and In Vivo Evaluation of Hypericin for Photodynamic Therapy of Equine Sarcoids by MARTENS, A., MOOR, A.D.E., WAELKENS, E., MERLEVEDE, W., DE WITTE, P.

“…The therapeutic potential of the photodynamic compound, hypericin, in the treatment of equine sarcoids was evaluated. The in vitro cytotoxicity was assessed…”
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