Search Results - "WADKINS, R. M"

Biochemical and molecular analysis of carboxylesterase‐mediated hydrolysis of cocaine and heroin by Hatfield, MJ, Tsurkan, L, Hyatt, JL, Yu, X, Edwards, CC, Hicks, LD, Wadkins, RM, Potter, PM

“…Background and purpose:  Carboxylesterases (CEs) metabolize a wide range of xenobiotic substrates including heroin, cocaine, meperidine and the anticancer…”
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Targeting DNA secondary structures by Wadkins, R M

“…DNA secondary structures containing regions of single-stranded DNA have now been identified in the genomic DNA of a number of prokaryotic and eukaryotic…”
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The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase by MORTON, C. L, WADKINS, R. M, DANKS, M. K, POTTER, P. M

“…Patients treated with high doses of CPT-11 rapidly develop a cholinergic syndrome that can be alleviated by atropine. Although CPT-11 was not a substrate for…”
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Detection of multiple toxic agents using a planar array immunosensor by Wadkins, Randy M., Golden, Joel P., Pritsiolas, Leo M., Ligler, Frances S.

“…A planar array immunosensor, equipped with a charge-coupled device (CCD) as a detector, was used to simultaneously detect 3 toxic analytes. Wells approximately…”
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Identification and Characterization of Novel Benzil (Diphenylethane-1,2-dione) Analogues as Inhibitors of Mammalian Carboxylesterases by Wadkins, Randy M, Hyatt, Janice L, Wei, Xin, Yoon, Kyoung Jin P, Wierdl, Monika, Edwards, Carol C, Morton, Christopher L, Obenauer, John C, Damodaran, Komath, Beroza, Paul, Danks, Mary K, Potter, Philip M

“…Carboxylesterases (CE) are ubiquitous enzymes responsible for the metabolism of xenobiotics. Because the structural and amino acid homology among esterases of…”
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Water soluble 20(S)-glycinate esters of 10,11-methylenedioxycamptothecins are highly active against human breast cancer xenografts by WADKINS, R. M, POTTER, P. M, VLADU, B, MARTY, J, MANGOLD, G, WEITMAN, S, MANIKUMAR, G, WANI, M. C, WALL, M. E, VON HOFF, D. D

“…Water-soluble 20(S)-glycinate esters of two highly potent 10,11-methylenedioxy analogues of camptothecin (CPT) have been synthesized and evaluated for their…”
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Actinomycin D and 7-aminoactinomycin D binding to single-stranded DNA by Wadkins, Randy M, Jovin, Thomas M

“…The potent RNA polymerase inhibitors actinomycin D and 7-aminoactinomycin D are shown to bind to single-stranded DNAs. The binding occurs with particular DNA…”
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7-Azidoactinomycin D: a novel probe for examining actinomycin D-DNA interactions by Graves, D E, Wadkins, R M

“…The technique of photoaffinity labeling is applied to the actinomycin D system to provide a novel probe for the examination of the interactions of actinomycin…”
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A combinatorial approach to the selective capture of circulating malignant epithelial cells by peptide ligands by Aggarwal, Saurabh, Janssen, Samuel, Wadkins, Randy M., Harden, James L., Denmeade, Samuel R.

“…Early detection is critical in the administration of definitive and curative therapy of cancer. However, current detection methods are ineffective at…”
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Thermodynamics of the interactions of m-AMSA and o-AMSA with nucleic acids: influence of ionic strength and DNA base composition by WADKINS, R. M, GRAVES, D. E

“…The equilibrium binding of the antitumor agent m-AMSA and its biologically inactive analog o-AMSA to native and synthetic DNAs are compared over a wide range…”
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Structural constraints affect the metabolism of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) by carboxylesterases by Wadkins, R M, Morton, C L, Weeks, J K, Oliver, L, Wierdl, M, Danks, M K, Potter, P M

“…7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin [CPT-11 (irinotecan)] is a water-soluble camptothecin-derived prodrug that is activated by…”
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Interactions of anilinoacridines with nucleic acids: effects of substituent modifications on DNA-binding properties by Wadkins, Randy M, Graves, David E

“…Spectroscopic methods are used to probe the interactions of several anilinoacridine analogues with calf thymus DNA over a wide range of temperatures and sodium…”
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Actinomycin D Binds to Metastable Hairpins in Single-Stranded DNA by Wadkins, Randy M, Vladu, Bogdan, Tung, Chang-Shung

“…We have examined the role of DNA composition in the binding of actinomycin D to single-stranded DNA. By using the fluorescent analogue 7-aminoactinomycin D, we…”
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Kinetics of cellular permeability of phenoxazine and its dependence on P-glycoprotein expression by Wadkins, Randy M., Houghton, Peter J.

“…We present here the initial characterization of the mechanism of reversal of cellular resistance to Vinca alkaloids by phenoxazine (PZ). Changes in…”
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7- and 10-substituted camptothecins: dependence of topoisomerase I-DNA cleavable complex formation and stability on the 7- and 10-substituents by Vladu, B, Woynarowski, J M, Manikumar, G, Wani, M C, Wall, M E, Von Hoff, D D, Wadkins, R M

“…7-Alkyl, 7-alkyl-10-hydroxy, 7-alkyl-10-methoxy, and 7-alkyl-10, 11-methylenedioxy analogs of camptothecin have been synthesized and evaluated for their…”
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The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase by Harel, Michal, Hyatt, Janice L., Brumshtein, Boris, Morton, Christopher L., Wadkins, Randy M., Silman, Israel, Sussman, Joel L., Potter, Philip M.

“…The anticancer prodrug CPT-11 is a highly effective camptothecin analog that has been approved for the treatment of colon cancer. The 2.6 Å resolution crystal…”
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Cooperative binding of m-AMSA to nucleic acids by ELMORE, R. H, WADKINS, R. M, GRAVES, D. E

“…The equilibrium binding of the antitumor agent m-AMSA (4'-(9-acridinylamino) methane-sulfon-m-ansidide) has been examined by optical methods. These studies…”
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The Role of the Loop in Binding of an Actinomycin D Analog to Hairpins Formed by Single-Stranded DNA by Wadkins, Randy M., Tung, Chang-Shung, Vallone, Peter M., Benight, Albert S.

“…Our recent work has indicated that the potent antibiotic and antitumor agent actinomycin D has the ability to selectively bind and stabilize single-stranded…”
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Apple Corps by Wadkins, Randy M., Ahern, Kevin

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Characterization of Topotecan-Mediated Redistribution of DNA Topoisomerase I by Digital Imaging Microscopy by Wadkins, Randy M., Danks, Mary K., Horowitz, Lisa, Baker, Sharyn D.

“…Topographical image measures have been used to characterize the subnuclear distribution of DNA topoisomerase I in human tumor cell lines. This topographical…”
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