Search Results - "WADA, Yoh"

Exploring the Link between Vacuolar-Type Proton ATPase and Epithelial Cell Polarity by Sun-Wada, Ge-Hong, Wada, Yoh

“…Vacuolar-type H+-ATPase (V-ATPase) was first identified as an electrogenic proton pump that acidifies the lumen of intracellular organelles. Subsequently, it…”
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Role of vacuolar-type proton ATPase in signal transduction by Sun-Wada, Ge-Hong, Wada, Yoh

“…The vacuolar H+-ATPase (V-ATPase) was first identified as an electrogenic proton pump that acidifies the lumen of intra- and extracellular compartments. The…”
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The a subunit isoforms of vacuolar-type proton ATPase exhibit differential distribution in mouse perigastrulation embryos by Sun-Wada, Ge-Hong, Wada, Yoh

“…Vacuolar-type H + -ATPases (V-ATPases) are large multi-subunit complexes that play critical roles in the acidification of a variety of intracellular or…”
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Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm by Sun-Wada, Ge-Hong, Tabata, Hiroyuki, Wada, Yoh

“…The endocytic compartments keep their interior acidic through the inward flow of protons and anions from the cytosol. Acidification is mediated by a proton…”
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The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts by Matsumoto, Naomi, Sekiya, Mizuki, Sun-Wada, Ge-Hong, Wada, Yoh, Nakanishi-Matsui, Mayumi

“…We have shown previously that the lysosomal a3 isoform of the a subunit of vacuolar-type ATPase (V-ATPase) interacts with inactive (GDP-bound form) Rab7, a…”
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Role of the Cytosolic Domain of the a3 Subunit of V-ATPase in the Interaction with Rab7 and Secretory Lysosome Trafficking in Osteoclasts by Nakanishi-Matsui, Mayumi, Matsumoto, Naomi, Sun-Wada, Ge-Hong, Wada, Yoh

“…We previously reported that the a3 subunit of proton-pumping vacuolar-type ATPase (V-ATPase) interacts with Rab7 and its guanine nucleotide exchange factor,…”
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Vacuolar-type ATPase: A proton pump to lysosomal trafficking by FUTAI, Masamitsu, SUN-WADA, Ge-Hong, WADA, Yoh, MATSUMOTO, Naomi, NAKANISHI-MATSUI, Mayumi

“…Vacuolar-type ATPase (V-ATPase), initially identified in yeast and plant vacuoles, pumps protons into the lumen of organelles coupled with ATP hydrolysis. The…”
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Dynamic visualization of RANKL and Th17-mediated osteoclast function by Kikuta, Junichi, Wada, Yoh, Kowada, Toshiyuki, Wang, Ze, Sun-Wada, Ge-Hong, Nishiyama, Issei, Mizukami, Shin, Maiya, Nobuhiko, Yasuda, Hisataka, Kumanogoh, Atsushi, Kikuchi, Kazuya, Germain, Ronald N, Ishii, Masaru

“…Osteoclasts are bone resorbing, multinucleate cells that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursor cells. Although…”
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The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H+-ATPase Assembly in Murine Cardiomyocytes by Kinouchi, Kenichiro, Ichihara, Atsuhiro, Sano, Motoaki, Sun-Wada, Ge-Hong, Wada, Yoh, Kurauchi-Mito, Asako, Bokuda, Kanako, Narita, Tatsuya, Oshima, Yoichi, Sakoda, Mariyo, Tamai, Yoshitaka, Sato, Hiromu, Fukuda, Keiichi, Itoh, Hiroshi

“…RATIONALE:The (pro)renin receptor [(P)RR], encoded in ATP6AP2, plays a key role in the activation of local renin-angiotensin system (RAS). A truncated form of…”
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Rab7 localized on zymogen granules is involved in maturation but not in autophagy or regulated exocytosis in pancreatic acinar cells by Takahashi, Kenichi, Mashima, Hirosato, Sekine, Masanari, Uehara, Takeshi, Asano, Takeharu, Sun-Wada, Ge-Hong, Wada, Yoh, Ohnishi, Hirohide

“…Rab7 is known to function in the autophagy and endocytosis pathways in eukaryocytes and is related to various diseases. We recently reported that Rab7 plays a…”
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Functional complementation of V-ATPase a subunit isoforms in osteoclasts by Matsumoto, Naomi, Sekiya, Mizuki, Fujimoto, Yasuyuki, Haga, Satoshi, Sun-Wada, Ge-Hong, Wada, Yoh, Nakanishi-Matsui, Mayumi

“…In osteoclasts, the a3 isoform of the proton-pumping V-ATPase plays essential roles in anterograde trafficking of secretory lysosomes and extracellular…”
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Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells by McGuire, Christina M., Collins, Michael P., Sun-Wada, GeHong, Wada, Yoh, Forgac, Michael

“…The vacuolar H+-ATPase (V-ATPase) is an ATP-driven proton pump present in various intracellular membranes and at the plasma membrane of specialized cell types…”
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Characterization of Rab32- and Rab38-positive lysosome-related organelles in osteoclasts and macrophages by Noda, Kazuya, Lu, Shiou-Ling, Chen, Siyu, Tokuda, Kanako, Li, Yangjie, Hao, Feike, Wada, Yoh, Sun-Wada, Ge-Hong, Murakami, Shinya, Fukuda, Mitsunori, Itoh, Takashi, Noda, Takeshi

“…Both the biogenesis and functions of osteoclasts and macrophages involves dynamic membrane traffic. We screened transcript levels for Rab family small GTPases…”
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Direct recruitment of H+-ATPase from lysosomes for phagosomal acidification by Sun-Wada, Ge-Hong, Tabata, Hiroyuki, Kawamura, Nobuyuki, Aoyama, Minako, Wada, Yoh

“…The nascent phagosome progressively establishes an acidic milieu by acquiring a proton pump, the vacuolar-type ATPase (V-ATPase). However, the origin of…”
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V-ATPase a3 isoform mutations identified in osteopetrosis patients abolish its expression and disrupt osteoclast function by Matsumoto, Naomi, Matsukawa, Reina, Takahashi, Shohei, Kudo, Koshi, Sun-Wada, Ge-Hong, Wada, Yoh, Nakanishi-Matsui, Mayumi

“…The a3 isoform of vacuolar-type proton-pumping ATPase (V-ATPase) is essential for bone resorption by osteoclasts. Although more than 90 mutations of the human…”
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Prorenin Receptor Is Essential for Normal Podocyte Structure and Function by OSHIMA, Yoichi, KINOUCHI, Kenichiro, YAMADA, Taketo, TAKEMOTO, Minoru, SALEEM, Moin A, QUAGGIN, Susan E, ITOH, Hiroshi, ICHIHARA, Atsuhiro, SAKODA, Mariyo, KURAUCHI-MITO, Asako, BOKUDA, Kanako, NARITA, Tatsuya, KUROSAWA, Hideaki, SUN-WADA, Ge-Hong, WADA, Yoh

“…The prorenin receptor is an accessory subunit of the vacuolar H(+)-ATPase, suggesting that it has fundamental functions beyond activation of the local…”
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The a3 isoform vacuolar type H⁺-ATPase promotes distant metastasis in the mouse B16 melanoma cells by Nishisho, Toshihiko, Hata, Kenji, Nakanishi, Masako, Morita, Yoshihiro, Sun-Wada, Ge-Hong, Wada, Yoh, Yasui, Natsuo, Yoneda, Toshiyuki

“…Accumulating evidence indicates that the acidic microenvironments critically influence malignant behaviors of cancer including invasiveness, metastasis, and…”
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Rab32 and Rab38 maintain bone homeostasis by regulating intracellular traffic in osteoclasts by Tokuda, Kanako, Lu, Shiou-Ling, Zhang, Zidi, Kato, Yumiko, Chen, Siyu, Noda, Kazuya, Hirose, Katsutoshi, Usami, Yu, Uzawa, Narikazu, Murakami, Shinya, Toyosawa, Satoru, Fukuda, Mitsunori, Sun-Wada, Ge-Hong, Wada, Yoh, Noda, Takeshi

“…Osteoclasts play a crucial role in bone homeostasis by forming resorption pits on bone surfaces, resulting in bone resorption. The osteoclast expression of…”
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Loss of G2 subunit of vacuolar-type proton transporting ATPase leads to G1 subunit upregulation in the brain by Kawamura, Nobuyuki, Sun-Wada, Ge-Hong, Wada, Yoh

“…Vacuolar-type ATPase (V-ATPase) is a primary proton pump with versatile functions in various tissues. In nerve cells, V-ATPase is required for accumulation of…”
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Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment by Matsumoto, Naomi, Sekiya, Mizuki, Tohyama, Koujiro, Ishiyama-Matsuura, Eri, Sun-Wada, Ge-Hong, Wada, Yoh, Futai, Masamitsu, Nakanishi-Matsui, Mayumi

“…Secretory lysosomes are required for the specialised functions of various types of differentiated cells. In osteoclasts, the lysosomal proton pump V-ATPase…”
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