Search Results - "WACKER, D. A"

Site-specific incorporation of nonnatural residues during in vitro protein biosynthesis with semisynthetic aminoacyl-tRNAs by BAIN, J. D, DIALA, E. S, GLABE, C. G, WACKER, D. A, LYTTLE, M. H, DIX, T. A, CHAMBERLIN, A. R

“…A method is presented for the incorporation of nonnatural amino acids into proteins during in vitro cell-free translation. A combination of chemical synthesis…”
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Irreversible Inhibition of High‐Affinity [3H]Kainate Binding by a Novel Photoactivatable Analogue: (2′S,3′S,4′R)‐2′‐Carboxy‐4′‐(2‐Diazo‐1‐Oxo‐3,3,3‐Trifluoropropyl)‐3′‐Pyrrolidinyl Acetate by Willis, Colin L., Wacker, Dean A., Bartlett, Richard D., Bleakman, David, Lodge, David, Chamberlin, A. Richard, Bridges, Richard J.

“…: A photolabile trifluoromethyldiazoketone derivative of kainate (KA), (2′S,3′S,4′R)‐2′‐carboxy‐4′‐(2‐diazo‐1‐oxo‐3,3,3‐trifluoropropyl)‐3′‐pyrrolidinyl…”
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Specific Contributions of Histone Tails and their Acetylation to the Mechanical Stability of Nucleosomes by Brower-Toland, Brent, Wacker, David A., Fulbright, Robert M., Lis, John T., Kraus, W. Lee, Wang, Michelle D.

“…The distinct contributions of histone tails and their acetylation to nucleosomal stability were examined by mechanical disruption of individual nucleosomes in…”
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Efficient solid-phase synthesis of 2,3-substituted indoles by Wacker, Dean A, Kasireddy, Padmaja

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Discovery and development of 5-HT(₂C) receptor agonists for obesity: is there light at the end of the tunnel? by Miller, Keith J, Wacker, Dean A

“…Ever since the observation of late-onset obesity during the phenotypic characterization of the 5-HT(₂C) knock-out mouse, the serotonin 5-HT(₂C) receptor has…”
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Discovery of CC Chemokine Receptor-3 (CCR3) Antagonists with Picomolar Potency by De Lucca, George V, Kim, Ui Tae, Vargo, Brian J, Duncia, John V, Santella, Joseph B, Gardner, Daniel S, Zheng, Changsheng, Liauw, Ann, Wang, Zhang, Emmett, George, Wacker, Dean A, Welch, Patricia K, Covington, Maryanne, Stowell, Nicole C, Wadman, Eric A, Das, Anuk M, Davies, Paul, Yeleswaram, Swamy, Graden, Danielle M, Solomon, Kimberly A, Newton, Robert C, Trainor, George L, Decicco, Carl P, Ko, Soo. S

“…Starting with our previously described20 class of CC chemokine receptor-3 (CCR3) antagonist, we improved the potency by replacing the phenyl linker of 1 with a…”
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Patient Outcomes and Unit Composition With Transition to a High-Intensity ICU Staffing Model: A Before-and-After Study by Proper, Jennifer L, Wacker, David A, Shaker, Salma, Heisdorffer, Jamie, Shaker, Rami M, Shiue, Larissa T, Pendleton, Kathryn M, Siegel, Lianne K, Reilkoff, Ronald A

“…Provider staffing models for ICUs are generally based on pragmatic necessities and historical norms at individual institutions. A better understanding of the…”
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Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases by Wacker, Dean A, Miller, Keith J

“…The serotonin 5-HT2C receptor is a G-protein-coupled receptor and is one of the 14 subtypes that constitutes the serotonin receptor family. Agonists of 5-HT2C…”
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Discovery of (R)-9-Ethyl-1,3,4,10b-tetrahydro-7- trifluoromethylpyrazino[2,1-a]isoindol- 6(2H)-one, a Selective, Orally Active Agonist of the 5-HT sub(2C) Receptor by Wacker, DA, Varnes, J G, Malmstrom, SE, Cao, X, Hung, C-P, Ung, T, Wu, G, Zhang, G, Zuvich, E, Thomas, MA, Keim, W J, Cullen, MJ, Rohrbach, K W, Qu, Q

“…Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the…”
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Discovery of N-propylurea 3-benzylpiperidines as selective CC chemokine receptor-3 (CCR3) antagonists by Varnes, Jeffrey G, Gardner, Daniel S, Santella, Joseph B, Duncia, John V, Estrella, Melissa, Watson, Paul S, Clark, Cheryl M, Ko, Soo S, Welch, Patricia, Covington, Maryanne, Stowell, Nicole, Wadman, Eric, Davies, Paul, Solomon, Kimberley, Newton, Robert C, Trainor, George L, Decicco, Carl P, Wacker, Dean A

“…The discovery of novel and selective small molecule antagonists of the CC Chemokine Receptor-3 (CCR3) is presented. Simple conversion from a 4- to…”
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CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure–activity relationships by Wacker, Dean A, Santella, III, Joseph B, Gardner, Daniel S, Varnes, Jeffrey G, Estrella, Melissa, DeLucca, George V, Ko, Soo S, Tanabe, Keiichi, Watson, Paul S, Welch, Patricia K, Covington, Maryanne, Stowell, Nicole C, Wadman, Eric A, Davies, Paul, Solomon, Kimberly A, Newton, Robert C, Trainor, George L, Friedman, Steven M, Decicco, Carl P, Duncia, John V

“…CCR3 antagonist leads with IC 50 values in the μM range were converted into low nM binding compounds that displayed in vitro inhibition of human eosinophil…”
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N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists by Batt, Douglas G., Houghton, Gregory C., Roderick, John, Santella, Joseph B., Wacker, Dean A., Welch, Patricia K., Orlovsky, Yevgeniya I., Wadman, Eric A., Trzaskos, James M., Davies, Paul, Decicco, Carl P., Carter, Percy H.

“…The synthesis and structure–activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented…”
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Shock by Wacker, David A., MD, PhD, Winters, Michael E., MD

“…Critically ill patients with undifferentiated shock are complex and challenging cases in the ED. A systematic approach to assessment and management is…”
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Preparation of chemically misacylated semisynthetic nonsense suppressor tRNAs employed in biosynthetic incorporation of non-natural residues into proteins by Bain, J. D, Wacker, Dean A, Kuo, Eric E, Lyttle, Matthew H, Chamberlin, A. Richard

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Facile preparation of chloromethylaryl solid supports using methanesulfonyl chloride and Hunig's base by Nugiel, David A, Wacker, Dean A, Nemeth, Gregory A

“…Several commercially available hydroxymethylaryl resins were converted to their corresponding chloromethyl analogs by simple treatment with methanesulfonyl…”
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Irreversible inhibition of high-affinity [ super(3)H] kainate binding by a novel photoactivatable analogue: (2' S,3' S,4' R)-2'-carboxy-4'-(2-diazo-1-oxo-3,3,3-trifluoropropyl)-3'-pyrrolid inyl acetate by Willis, CL, Wacker, DA, Bartlett, R D, Bleakman, D, Lodge, D, Chamberlin, A R, Bridges, R J

“…A photolabile trifluoromethyldiazoketone derivative of kainate (KA), (2' S,3' S,4' R)-2'-carboxy-4'-(2-diazo-1-oxo-3,3,3-trifluoropropyl)-3'-pyrrolid i nyl…”
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Solid-Phase Synthesis of Alkyl Aryl Ethers via the Ullmann Condensation by Xiao, Li, Rongshi, Hurst, David, Zhuang, Hui, Shi, Shuhao, Czarnik, Anthony W, Robichaud, Albert J, Wacker, Dean A, Robertson, David W

“…Alkyl aryl ether formation is a frequently employed reaction in organic synthesis. Ullmann condensation is an alternative method to the widely used Mitsunobu…”
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