Search Results - "W. Ronald Shehee"

Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion coupling by Roe, M W, Worley, 3rd, J F, Mittal, A A, Kuznetsov, A, DasGupta, S, Mertz, R J, Witherspoon, 3rd, S M, Blair, N, Lancaster, M E, McIntyre, M S, Shehee, W R, Dukes, I D, Philipson, L H

“…Voltage-dependent delayed rectifier K+ channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles…”
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Lethal Thalassemia After Insertional Disruption of the Mouse Major Adult β-Globin Gene by Shehee, W. Ronald, Oliver, Paula, Smithies, Oliver

“…Thalassemias are hereditary anemias caused by mutations that disturb the normal 1:1 balance of α- and β-globin chains that form hemoglobin. We have disrupted…”
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Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy by Detloff, P J, Lewis, J, John, S W, Shehee, W R, Langenbach, R, Maeda, N, Smithies, O

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Lethal thalassemia after insertional disruption of the mouse major adult (beta)-globin gene by Shehee, W Ronald, Oliver, Paula, Smithies, Oliver

“…Thalassemias are hereditary anemias caused by mutations that disturb the normal 1:1 balance of alpha- and beta-globin chains that form hemoglobin. The major…”
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Expression and Function of Pancreatic β-Cell Delayed Rectifier K+ Channels by Michael Wm. Roe, Jennings F. Worley III, Anshu A. Mittal, Andrey Kuznetsov, Sarmila DasGupta, Robert J. Mertz, Sam M. Witherspoon III, Nathaniel Blair, Mary E. Lancaster, Margaret S. McIntyre, W. Ronald Shehee, Iain D. Dukes, Louis H. Philipson

“…Voltage-dependent delayed rectifier K + channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles…”
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Expression and Function of Pancreatic β-Cell Delayed Rectifier K+ Channels by Roe, Michael Wm, Worley, Jennings F., Mittal, Anshu A., Kuznetsov, Andrey, DasGupta, Sarmila, Mertz, Robert J., Witherspoon, Sam M., Blair, Nathaniel, Lancaster, Mary E., McIntyre, Margaret S., Shehee, W. Ronald, Dukes, Iain D., Philipson, Louis H.

“…Voltage-dependent delayed rectifier K+ channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles…”
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Correction of a Human βS-Globin Gene by Gene Targeting by Shesely, Edward G., Kim, Hyung-Suk, Shehee, W. Ronald, Papayannopoulou, Thalia, Smithies, Oliver, Popovich, Bradley W.

“…As a step toward using gene targeting for gene therapy, we have corrected a human βS-globin gene to the normal βAallele by homologous recombination in the…”
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Determination of a functional ancestral sequence and definition of the 5' end of A-type mouse L1 elements by Shehee, W R, Chao, S F, Loeb, D D, Comer, M B, Hutchison, 3rd, C A, Edgell, M H

“…The complete nucleotide sequence of L1Md-A13, a 6372 base-pair (bp) member of the L1Md repetitive family isolated from a BALB/c mouse genomic DNA library, is…”
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Problems encountered in detecting a targeted gene by the polymerase chain reaction by Kim, H S, Popovich, B W, Shehee, W R, Shesely, E G, Smithies, O

“…We have investigated problems encountered when using the polymerase chain reaction (PCR) to detect recombinants in gene targeting experiments in which…”
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Rapid genotyping of mice with hemoglobinopathies and globin transgenes by Whitney, 3rd, J B, Leder, A, Lewis, J, Popp, R A, Paszty, C, Rubin, E M, Shehee, W R, Townes, T M, Smithies, O

“…The hematology of the laboratory mouse has been well characterized. Normal genetic differences at the alpha- and beta-globin gene loci serve as useful markers…”
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Deletion and Replacement of the Mouse Adult β-Globin Genes by a "Plug and Socket" Repeated Targeting Strategy by Detloff, Peter J., Lewis, Jada, John, Simon W. M., Shehee, W. Ronald, Langenbach, Robert, Maeda, Nobuyo, Smithies, Oliver

“…We describe a two-step strategy to alter any mouse locus repeatedly and efficiently by direct positive selection. Using conventional targeting for the first…”
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