Search Results - "W. Dalby-Brown"

Vasorelaxant effects of novel Kv7.4 channel enhancers ML213 and NS15370 by Jepps, T A, Bentzen, B H, Stott, J B, Povstyan, O V, Sivaloganathan, K, Dalby‐Brown, W, Greenwood, I A

“…Background and Purpose The KCNQ‐encoded voltage‐gated potassium channel family (Kv7.1‐Kv7.5) are established regulators of smooth muscle contractility, where…”
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Activation of KV7 channels stimulates vasodilatation of human placental chorionic plate arteries by Mills, T.A., Greenwood, S.L., Devlin, G., Shweikh, Y., Robinson, M., Cowley, E., Hayward, C.E., Cottrell, E.C., Tropea, T., Brereton, M.F., Dalby-Brown, W., Wareing, M.

“…Potassium (K+) channels are key regulators of vascular smooth muscle cell (VSMC) excitability. In systemic small arteries, Kv7 channel expression/activity has…”
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Activation of K V 7 channels stimulates vasodilatation of human placental chorionic plate arteries by Mills, T.A., Greenwood, S.L., Devlin, G., Shweikh, Y., Robinson, M., Cowley, E., Hayward, C.E., Cottrell, E.C., Tropea, T., Brereton, M.F., Dalby-Brown, W., Wareing, M.

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Salicylate- and quinine-induced tinnitus and effects of memantine by Lobarinas, E., Yang, G., Sun, W., Ding, D., Mirza, N., Dalby-Brown, W., Hilczmayer, E., Fitzgerald, S., Zhang, Liyan, Salvi, R.

“…Conclusion: Memantine, an antiglutamatergic drug, has been proposed as a treatment for tinnitus. Objectives: The purpose of this study was to determine if…”
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Retigabine: Chemical Synthesis to Clinical Application by Blackburn‐Munro, G., Dalby‐Brown, W., Mirza, N. R., Mikkelsen, J. D., Blackburn‐Munro, R. E.

“…ABSTRACT Retigabine [D23129; N‐(2‐amino‐4‐(4‐fluorobenzylamino)‐phenyl)carbamic acid ethyl ester] is an antiepileptic drug with a recently described novel…”
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Vasorelaxant effects of novel K v 7.4 channel enhancers ML 213 and NS 15370 by Jepps, T A, Bentzen, B H, Stott, J B, Povstyan, O V, Sivaloganathan, K, Dalby‐Brown, W, Greenwood, I A

“…Background and Purpose The KCNQ ‐encoded voltage‐gated potassium channel family ( K v 7.1‐ K v 7.5) are established regulators of smooth muscle contractility,…”
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Blockade of oncogenic notch1 with the new serca inhibitor cad204520 in t-cell acute lymphoblastic leukemia by M. Marchesini, A. Gherli, A. Montanaro, C. Sorrentino, L. Pagliaro, C. Rompietti, S. Kitara, F. Rizzi, D. Stilli, R. La Starza, C. Mecucci, K. Stegmaier, A.M. Lund Winter, P. Sportoletti, M. Bublitz, W. Dalby-Brown, G. Roti

“…The discovery of the P-type ATPase Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) as a bidirectional modulator of oncogenic NOTCH1 suggests an innovative…”
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Activation of KV 7 channels stimulates vasodilatation of human placental chorionic plate arteries by Mills, T.A, Greenwood, S.L, Devlin, G, Shweikh, Y, Robinson, M, Cowley, E, Hayward, C.E, Cottrell, E.C, Tropea, T, Brereton, M.F, Dalby-Brown, W, Wareing, M

“…Abstract Introduction Potassium (K+ ) channels are key regulators of vascular smooth muscle cell (VSMC) excitability. In systemic small arteries, Kv 7 channel…”
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PF158 TARGETING ONCOGENIC NOTCH1 IN T‐CELL ACUTE LYMPHOBLASTIC LEUKEMIA WITH A NEW SELECTIVE SERCA INHIBITOR CAD204520 by Marchesini, M., Gherli, A., Winter, A.‐M. Lund, Patrizi, L., Kitara, S., Montanaro, A., Rompietti, C., Sorrentino, C., Stilli, D., Rizzi, F., Loiacono, C., Pagliaro, L., La Starza, R., Mecucci, C., Aversa, F., Sportoletti, P., Dalby‐Brown, W., Roti, G.

“…Background: Several studies support the development of NOTCH1 inhibitors for targeted cancer therapy. This idea is most compelling for T‐cell acute…”
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Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370 by Jepps, T A, Bentzen, B H, Stott, J B, Povstyan, O V, Sivaloganathan, K, Dalby-Brown, W, Greenwood, I A

“…The KCNQ-encoded voltage-gated potassium channel family (Kv 7.1-Kv 7.5) are established regulators of smooth muscle contractility, where Kv 7.4 and Kv 7.5…”
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