Search Results - "W Byl, Jo Ann"

Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases by Jian, Jeffrey Y, McCarty, Kevin D, Byl, Jo Ann W, Guengerich, F Peter, Neuman, Keir C, Osheroff, Neil

“…Abstract To perform double-stranded DNA passage, type II topoisomerases generate a covalent enzyme-cleaved DNA complex (i.e. cleavage complex). Although this…”
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Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci by Yu, Xiang, Davenport, James W, Urtishak, Karen A, Carillo, Marie L, Gosai, Sager J, Kolaris, Christos P, Byl, Jo Ann W, Rappaport, Eric F, Osheroff, Neil, Gregory, Brian D, Felix, Carolyn A

“…Type II topoisomerases orchestrate proper DNA topology, and they are the targets of anti-cancer drugs that cause treatment-related leukemias with balanced…”
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Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks by Dauda, Soziema E, Collins, Jessica A, Byl, Jo Ann W, Lu, Yanran, Yalowich, Jack C, Mitton-Fry, Mark J, Osheroff, Neil

“…Novel bacterial topoisomerase inhibitors (NBTIs) are an emerging class of antibacterials that target gyrase and topoisomerase IV. A hallmark of NBTIs is their…”
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Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination by Heintzman, Darren R., Campos, Lillian V., Byl, Jo Ann W., Osheroff, Neil, Dewar, James M.

“…Termination of DNA replication occurs when two replication forks converge upon the same stretch of DNA. Resolution of topological stress by topoisomerases is…”
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Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II by Hawtin, Rachael E, Stockett, David E, Byl, Jo Ann W, McDowell, Robert S, Nguyen, Tan, Arkin, Michelle R, Conroy, Andrew, Yang, Wenjin, Osheroff, Neil, Fox, Judith A

“…Topoisomerase II is critical for DNA replication, transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including…”
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DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA by Lee, Sanghwa, Jung, Seung-Ryoung, Heo, Kang, Byl, Jo Ann W, Deweese, Joseph E, Osheroff, Neil, Hohng, Sungchul

“…Topoisomerase II resolves intrinsic topological problems of double-stranded DNA. As part of its essential cellular functions, the enzyme generates DNA breaks,…”
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Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events by Kristoffersen, Emil L, Givskov, Asger, Jørgensen, Line A, Jensen, Pia W, W Byl, Jo Ann, Osheroff, Neil, Andersen, Anni H, Stougaard, Magnus, Ho, Yi-Ping, Knudsen, Birgitta R

“…DNA nano-structures present appealing new means for monitoring different molecules. Here, we demonstrate the assembly and utilization of a surface-attached…”
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Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids by Huseman, Eric D, Byl, Jo Ann W, Chapp, Scott M, Schley, Nathan D, Osheroff, Neil, Townsend, Steven D

“…The arimetamycin A glycan governs the compound’s cytotoxicity (IC50). To study this branched, deoxy-amino disaccharide, we designed and synthesized a modified…”
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Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation by Furniss, Katherine L, Tsai, Hung-Ji, Byl, Jo Ann W, Lane, Andrew B, Vas, Amit C, Hsu, Wei-Shan, Osheroff, Neil, Clarke, Duncan J

“…By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes…”
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Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms by Van Ravenstein, Sabrina X, Mehta, Kavi P, Kavlashvili, Tamar, Byl, Jo Ann W, Zhao, Runxiang, Osheroff, Neil, Cortez, David, Dewar, James M

“…Topoisomerase II (TOP2) unlinks chromosomes during vertebrate DNA replication. TOP2 “poisons” are widely used chemotherapeutics that stabilize TOP2 complexes…”
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Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity by Govender, Preshendren, Müller, Rudolf, Singh, Kawaljit, Reddy, Virsinha, Eyermann, Charles J., Fienberg, Stephen, Ghorpade, Sandeep R., Koekemoer, Lizbé, Myrick, Alissa, Schnappinger, Dirk, Engelhart, Curtis, Meshanni, Jaclynn, Byl, Jo Ann W., Osheroff, Neil, Singh, Vinayak, Chibale, Kelly, Basarab, Gregory S.

“…New antibiotics with either a novel mode of action or novel mode of inhibition are urgently needed to overcome the threat of drug-resistant tuberculosis (TB)…”
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First Ruthenium Organometallic Complex of Antibacterial Agent Ofloxacin. Crystal Structure and Interactions with DNA by Turel, Iztok, Kljun, Jakob, Perdih, Franc, Morozova, Elena, Bakulev, Vladimir, Kasyanenko, Nina, Byl, Jo Ann W, Osheroff, Neil

“…An organometallic ruthenium complex of quinolone antibacterial agent ofloxacin, [(η6-p-cymene)RuCl(O,O-oflo)]·2.8H2O (1·2.8H2O), was isolated, and its crystal…”
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Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β by Ortega, Jose Antonio, Arencibia, Jose M, Minniti, Elirosa, Byl, Jo Ann W, Franco-Ulloa, Sebastian, Borgogno, Marco, Genna, Vito, Summa, Maria, Bertozzi, Sine Mandrup, Bertorelli, Rosalia, Armirotti, Andrea, Minarini, Anna, Sissi, Claudia, Osheroff, Neil, De Vivo, Marco

“…We disclose a novel class of 6-amino-tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of anticancer drugs. In…”
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Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα by Minniti, Elirosa, Byl, Jo Ann W., Riccardi, Laura, Sissi, Claudia, Rosini, Michela, De Vivo, Marco, Minarini, Anna, Osheroff, Neil

“…[Display omitted] It has been proposed that xanthone derivatives with anticancer potential act as topoisomerase II inhibitors because they interfere with the…”
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Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ by Smith, Nicholas A, Byl, Jo Ann W, Mercer, Susan L, Deweese, Joseph E, Osheroff, Neil

“…Etoposide is a topoisomerase II poison that is utilized to treat a broad spectrum of human cancers. Despite its wide clinical use, 2–3% of patients treated…”
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Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA by Jang, Yunsu, Son, Heyjin, Lee, Sang-Wook, Hwang, Wonseok, Jung, Seung-Ryoung, Byl, Jo Ann W, Osheroff, Neil, Lee, Sanghwa

“…Topoisomerase II cleaves DNA at preferred sequences with different efficiencies; however, the mechanism of cleavage site selection is not known. Here we used…”
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A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase by Byl, Jo Ann W., Mueller, Rudolf, Bax, Ben, Basarab, Gregory S., Chibale, Kelly, Osheroff, Neil

“…The rise in drug-resistant tuberculosis has necessitated the search for alternative antibacterial treatments. Spiropyrimidinetriones (SPTs) represent an…”
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Epimerization of Green Tea Catechins during Brewing Does Not Affect the Ability to Poison Human Type II Topoisomerases by Timmel, M. Anne, Byl, Jo Ann W, Osheroff, Neil

“…(−)-Epigallocatechin gallate (EGCG) is the most abundant and biologically active polyphenol in green tea (Camellia sinensis) leaves, and many of its cellular…”
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Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia by Mays, Ashley N., Osheroff, Neil, Xiao, Yuanyuan, Wiemels, Joseph L., Felix, Carolyn A., Byl, Jo Ann W., Saravanamuttu, Kandeepan, Peniket, Andrew, Corser, Robert, Chang, Cherry, Hoyle, Christine, Parker, Anne N., Hasan, Syed K., Lo-Coco, Francesco, Solomon, Ellen, Grimwade, David

“…Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17)(q22;q21) involving the PML and RARA genes is associated with exposure to agents targeting…”
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Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis by Hasan, Syed Khizer, Mays, Ashley N., Ottone, Tiziana, Ledda, Antonio, La Nasa, Giorgio, Cattaneo, Chiara, Borlenghi, Erika, Melillo, Lorella, Montefusco, Enrico, Cervera, José, Stephen, Christopher, Satchi, Gnanam, Lennard, Anne, Libura, Marta, Byl, Jo Ann W., Osheroff, Neil, Amadori, Sergio, Felix, Carolyn A., Voso, Maria Teresa, Sperr, Wolfgang R., Esteve, Jordi, Sanz, Miguel A., Grimwade, David, Lo-Coco, Francesco

“…Therapy-related acute promyelocytic leukemia (t-APL) with t(15;17) translocation is a well-recognized complication of cancer treatment with agents targeting…”
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