Search Results - "W Busby, Jr"

Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes by T Arai, A Parker, W Busby, Jr, D R Clemmons

“…The mechanisms by which insulin-like growth factor-I (IGF-I) is released from insulin-like growth factor binding proteins (IGFBPs) and then binds to its…”
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An Insulin-Like Growth Factor (IGF) Binding Protein Enhances the Biologic Response to IGF-I by Elgin, R. G., Busby, W. H., Clemmons, D. R.

“…The insulin-like growth factors IGF-I and IGF-II circulate in blood bound to carrier proteins. The higher molecular mass IGF-binding protein complex (150 kDa)…”
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Purification of a 31,000-dalton insulin-like growth factor binding protein from human amniotic fluid. Isolation of two forms with different biologic actions by Busby, W H, Klapper, D G, Clemmons, D R

“…Human amniotic fluid has been shown to contain a protein that binds insulin-like growth factor I and II (IGF-I and IGF-II). Partially purified preparations of…”
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An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes by Busby, W H, Quackenbush, G E, Humm, J, Youngblood, W W, Kizer, J S

“…The mechanism for the post-translational conversion of glutamine to pyroglutamic acid on the N terminus of newly synthesized peptides and proteins is unknown…”
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A highly conserved insulin-like growth factor-binding protein (IGFBP-5) is expressed during myoblast differentiation by James, P.L., Jones, S.B., Busby, W H, Clemmons, D.R., Rotwein, P

“…Insulin-like growth factor-binding proteins (IGFBPs) are a family of secreted proteins that bind insulin-like growth factors I and II (IGFs I and II) and are…”
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Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence by J I Jones, A Gockerman, W H Busby, Jr, G Wright, D R Clemmons

“…Insulin-like growth factor (IGF)-binding protein 1 (IGFBP-1) contains an Arg-Gly-Asp (RGD) integrin recognition sequence. In vitro mutagenesis was used to…”
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Identification of the sites of phosphorylation in insulin-like growth factor binding protein-1. Regulation of its affinity by phosphorylation of serine 101 by J I Jones, W H Busby, Jr, G Wright, C E Smith, N M Kimack, D R Clemmons

“…Serine phosphorylation of insulin-like growth factor binding protein-1 (IGFBP-1) has been shown to alter its affinity for the insulin-like growth factors…”
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Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion by C Camacho-Hubner, W H Busby, Jr, R H McCusker, G Wright, D R Clemmons

“…Human fibroblasts secrete insulin-like growth factor-binding proteins (IGFBPs) that can modify insulin-like growth factor (IGF) I action. We have determined…”
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The Complement Component C1s Is the Protease That Accounts for Cleavage of Insulin-like Growth Factor-binding Protein-5 in Fibroblast Medium by Busby, Walker H., Nam, Taek-Jeong, Moralez, Anna, Smith, Christine, Jennings, Michael, Clemmons, David R.

“…Cultured fibroblasts secrete an 88-kDa serine protease that cleaves insulin-like growth factor binding protein-5 (IGFBP-5). Because IGFBP-5 has been shown to…”
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Dose-response relationships of the tumorigenicity of cyclopenta[cd]pyrene, benzo[a]pyrene and 6-nitrochrysene in a newborn mouse lung adenoma bioassay by Busby, Jr, W F, Stevens, E K, Kellenbach, E R, Cornelisse, J, Lugtenburg, J

“…Cyclopenta[cd]pyrene (CPP) was a potent tumorigen when tested over a 5-fold dose range in the newborn mouse assay. A 20-fold increase in lung tumor…”
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Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects by Clemmons, D R, Snyder, D K, Busby, Jr, W H

“…Insulin-like growth factor binding protein-2 (IGFBP-2) is one of a family of IGFBPs that are present in extracellular fluids, and binds both IGF-II and IGF-I…”
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Nonenzymatic peptide alpha-amidation. Implications for a novel enzyme mechanism by Bateman, R C, Youngblood, W W, Busby, W H, Kizer, J S

“…An abiotic system is described which chemically catalyzes the formation of less than Glu-His-Pro-NH2 (thyrotropin-releasing hormone) from less than…”
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Biochemical and functional analysis of a conserved IGF-binding protein isolated from rainbow trout (Oncorhynchus mykiss) hepatoma cells by Bauchat, Busby WH, Garmong, A, Swanson, P, Moore, J, Lin, M, Duan, C

“…Rainbow trout (Oncorhynchus mykiss) serum contains several IGF-binding proteins (IGFBPs) that specifically bind to IGFs. The structures of these fish IGFBPs…”
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Purification and characterization of a peptidyl glycine monooxygenase from porcine pituitary by Kizer, J S, Bateman, Jr, R C, Miller, C R, Humm, J, Busby, Jr, W H, Youngblood, W W

“…A peptide alpha-amidating enzyme was purified to apparent homogeneity from porcine pituitary. This enzyme is a glycoprotein with a mol wt of 64,000, a metal…”
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Identification of the Extracellular Matrix Binding Sites for Insulin-like Growth Factor-binding Protein 5 by Parker, Alex, Clarke, Jane Badley, Busby, Walker H., Clemmons, David R.

“…Fibroblast extracellular matrix (ECM) contains two forms of insulin-like growth factor-binding proteins (IGFBPs), IGFBP-3 and IGFBP-5. These studies were…”
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Tumorigenicity of fluoranthene in a newborn mouse lung adenoma bioassay by Busby, Jr, W F, Goldman, M E, Newberne, P M, Wogan, G N

“…A 24 week lung adenoma bioassay using newborn mice was employed to determine the tumorigenicity of fluoranthene, a common environmental polynuclear aromatic…”
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Comparative lung tumorigenicity of parent and mononitro-polynuclear aromatic hydrocarbons in the BLU:Ha newborn mouse assay by Busby, Jr, W F, Stevens, E K, Martin, C N, Chow, F L, Garner, R C

“…A BLU:Ha newborn mouse lung adenoma bioassay was employed to compare the tumorigenicity of selected mononitroarenes and unsubstituted parent compounds 6 months…”
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Carcinogenicity in rats of the nitrosated bile acid conjugates N-nitrosoglycocholic acid and N-nitrosotaurocholic acid by BUSBY, W. F. JR, SHUKER, D. E. G, CHARNLEY, G, NEWBERNE, P. M, TANNENBAUM, S. R, WOGAN, G. N

“…Two nitrosated bile acid conjugates, N-nitrosoglycocholic acid and N-nitrosotaurocholic acid, were examined for carcinogenicity in a 2-year study with male…”
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Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): comparison of its structural and functional properties with IGFBP-1 by Bourner, M J, Busby, Jr, W H, Siegel, N R, Krivi, G G, McCusker, R H, Clemmons, D R

“…Insulin-like growth factor binding proteins (IGFBPs) are secreted by several cell types and can modify IGF actions. Mandin-Darby Bovine Kidney (MDBK) cells…”
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Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA-expressed human cytochromes P-450 by BUSBY, W. F, ACKERMANN, J. M, CRESPI, C. L

“…The effects of methanol, ethanol, dimethyl sulfoxide (DMSO), and acetonitrile were studied in vitro on nine individual, cDNAexpressed cytochrome P-450…”
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