Search Results - "Würthwein, G."

Serial assessment of pulmonary lesion volume by computed tomography allows survival prediction in invasive pulmonary aspergillosis by Vehreschild, J. J., Heussel, C. P., Groll, A. H., Vehreschild, M. J. G. T., Silling, G., Würthwein, G., Brecht, M., Cornely, O. A.

“…Background Serial chest CT is the standard of care to establish treatment success in invasive pulmonary aspergillosis (IPA). Data are lacking how response…”
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Phase II Dose Escalation Study of Caspofungin for Invasive Aspergillosis by COMELY, O. A, VEHRESCHILD, J. J, HARNISCHMACHER, U, WILKENS, A, FAROWSKI, F, KARTHAUS, M, LEHRNBECHER, T, ULLMANN, A. J, HALLEK, M, GROLL, A. H, VEHRESCHILD, M. J. G. T, WÜRTHWEIN, G, ARENZ, D, SCHWARTZ, S, HEUSSEL, C. P, SILLING, G, MAHNE, M, FRANKLIN, J

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Continuous or repeated prolonged cisplatin infusions in children: A prospective study on ototoxicity, platinum concentrations, and standard serum parameters by Lanvers-Kaminsky, C., Krefeld, B., Dinnesen, A.G., Deuster, D., Seifert, E., Würthwein, G., Jaehde, U., Pieck, A.C., Boos, J.

“…Background To overcome the ototoxicity of cisplatin, single bolus infusions were replaced by repeated prolonged infusions of lower doses or by continuous…”
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Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations by Boos, J., Werber, G., Ahlke, E., Schulze-Westhoff, P., Nowak-Göttl, U., Würthwein, G., Verspohl, E.J., Ritter, J., Jürgens, H.

“…The antileukaemic enzyme l-asparaginase is used to achieve the greatest possible reduction in blood levels of the amino acid asparagine, an essential factor…”
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Serum asparaginase activities and asparagine concentrations in the cerebrospinal fluid after a single infusion of 2,500 IU/m(2) PEG asparaginase in children with ALL treated according to protocol COALL-06-97 by Vieira Pinheiro, J P, Wenner, K, Escherich, G, Lanvers-Kaminsky, C, Würthwein, G, Janka-Schaub, G, Boos, J

“…Pharmacological surrogate parameters are considered a useful tool in estimating the treatment intensity of asparaginase (ASNase) preparations. When a pegylated…”
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Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses by Mühlisch, J, Bajanowski, T, Rickert, C H, Roggendorf, W, Würthwein, G, Jürgens, H, Frühwald, M C

“…Certain risk groups among tumors of the central nervous system (CNS) in children take an almost inevitably fatal course. The elucidation of molecular…”
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Inhibition of Smoking-Induced Platelet Aggregation by Aspirin and Pycnogenol by Pütter, M., Grotemeyer, K.H.M., Würthwein, G., Araghi-Niknam, M., Watson, R.R., Hosseini, S., Rohdewald, P.

“…The effects of a bioflavonoid mixture, Pycnogenol, were assessed on platelet function in humans. Cigarette smoking increased heart rate and blood pressure…”
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Monitoring paracetamol metabolism after single and repeated administration in pediatric patients with neoplastic diseases by Koling, S, Hempel, G, Lanvers, C, Boos, J, Würthwein, G

“…Paracetamol (PCM) is frequently used in pediatric patients with neoplastic disease. It is metabolized mainly by conjugation, but at therapeutic concentrations,…”
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Asparagine synthetase activity in paediatric acute leukaemias: AML‐M5 subtype shows lowest activity by Dübbers, A., Würthwein, G., Müller, H. J., Schulze‐Westhoff, P., Winkelhorst, M., Kurzknabe, E., Lanvers, C., Pieters, R., Kaspers, G. J. L., Creutzig, U., Ritter, J., Boos, J.

“…Lack of sufficient cellular activity of asparagine synthetase (AS) in blast cells compared with normal tissue is thought to be the basis of the antileukaemic…”
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Drug monitoring of low‐dose PEG‐asparaginase (Oncaspartm) in children with relapsed acute lymphoblastic leukaemia by Vieira Pinheiro, J. P, Müller, H. J., Schwabe, D., Gunkel, M., Casimiro da Palma, J., Henze, G., Von Schütz, V., Winkelhorst, M., Würthwein, G., Boos, J.

“…Use of asparaginase (ASNase) in the treatment of relapsed childhood acute lymphoblastic leukaemia (ALL) is associated with a high rate of hypersensitive…”
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Frequent but borderline methylation of p16 INK4a and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses by Mühlisch, J., Bajanowski, T., Rickert, C. H., Roggendorf, W., Würthwein, G., Jürgens, H., Frühwald, M. C.

“…Certain risk groups among tumors of the central nervous system (CNS) in children take an almost inevitably fatal course. The elucidation of molecular…”
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Dose reduction of asparaginase under pharmacokinetic and pharmacodynamic control during induction therapy in children with acute lymphoblastic leukaemia by AHLKE, ELVIRA, NOWAK‐GO¨TTL, ULRIKE, SCHULZE‐WESTHOFF, PETRA, WERBER, GISELA, BO¨RSTE, HEDWIG, WU¨RTHWEIN, GUDRUN, JU¨RGENS, HERBERT, BOOS, JOACHIM

“…The enzyme asparaginase is an important element in the therapy of acute lymphoblastic leukaemia (ALL). The usual asparaginase dose as prescribed in the…”
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Serum asparaginase activities and asparagine concentrations in the cerebrospinal fluid after a single infusion of 2,500 IU/m2 PEG asparaginase in children with ALL treated according to protocol COALL-06-97 by Vieira Pinheiro, J.P., Wenner, K., Escherich, G., Lanvers-Kaminsky, C., Würthwein, G., Janka-Schaub, G., Boos, J.

“…Background and Procedure Pharmacological surrogate parameters are considered a useful tool in estimating the treatment intensity of asparaginase (ASNase)…”
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Monitoring of mycophenolic acid in the plasma of transplant patients by capillary electrophoresis by ÜNSALAN, S, HEMPEL, G, FOBKER, M, WÜRTHWEIN, G, BOOS, J

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Simulation tool for schedule-dependent etoposide exposure based on pharmacokinetic findings published in the literature by Würthwein, Gudrun, Boos, Joachim

“…It is the aim of this study to establish a simulation tool for etoposide (Eto) which can be used to interpret drug monitoring data in clinical practice and to…”
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Drug Monitoring of PEG-Asparaginase Treatment in Childhood Acute Lymphoblastic Leukemia and Non-Hodgkin's Lymphoma by Pinheiro, J.P. Vieira, Lanvers, C., Würthwein, G., Beier, R., Casimiro da Palma, J., von Stackelberg, A., Boos, J.

“…This is an updated review of the pharmacokinetic profile of PEG-asparaginase (PEG-ASNase) in childhood acute lymphoblastic leukemia (ALL) or non-Hodgkin's…”
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Activation of beclomethasone dipropionate by hydrolysis to beclomethasone-17-monopropionate by Würthwein, G, Rohdewald, P

“…The relative affinity of beclomethasone (B), beclomethasone-17-monopropionate (17-BMP), beclomethasone-21-monopropionate (21-BMP), and beclomethasone…”
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The stability of doxorubicin and idarubicin in plasma and whole blood by LAUBROCK, N, HEMPEL, G, SCHULZE-WESTHOFF, P, WÜRTHWEIN, G, FLEQE, S, BOOS, J

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Population pharmacokinetic approach to compare oral and i.v. administration of etoposide by Würthwein, G, Krümpelmann, S, Tillmann, B, Real, E, Schulze-Westhoff, P, Jürgens, H, Boos, J

“…The antitumor effect of etoposide (ETO) may be related to duration of exposure to a relatively low serum level while myelosuppression may be dependent on peak…”
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Frequent but borderline methylation of p16INK4a and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses by Mühlisch, J, Bajanowski, T, Rickert, C H, Roggendorf, W, Würthwein, G, Jürgens, H, Frühwald, M C

“…Certain risk groups among tumors of the central nervous system (CNS) in children take an almost inevitably fatal course. The elucidation of molecular…”
Get full text