Search Results - "Würgler, F E"

Inhibitory effects of heavy metals on cytochrome P4501A induction in permanent fish hepatoma cells by BRÜSCHWEILER, B. J, WÜRGLER, F. E, FENT, K

“…The interactions in vitro of heavy metals Cd(II), Co(II), Cu(II), Ni(II), Pb(II), and Zn(II) with cytochrome P4501A (CYP1A) induction response and enzyme…”
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Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae by Eugster, H P, Probst, M, Würgler, F E, Sengstag, C

“…Heterologous expression of cytochrome P-450 cDNAs in yeast is a potent instrument for the study of enzyme-specific parameters and can be used to answer…”
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High promutagen activating capacity of yeast microsomes containing human cytochrome P-450 1A and human NADPH-cytochrome P-450 reductase by Sengstag, C, Eugster, H P, Würgler, F E

“…Yeast Saccharomyces cerevisiae strains have been constructed that co-express cDNAs coding for the human cytochrome P-450 enzymes CYP1A1 or CYP1A2 in…”
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The potential genotoxicity of sorbates: effects on cell cycle in vitro in V79 cells and somatic mutations in Drosophila by Schlatter, J, Würgler, F E, Kränzlin, R, Maier, P, Holliger, E, Graf, U

“…Sodium sorbate, potassium sorbate and an oxidation product of sodium sorbate, 4,5-epoxy-2-hexenoic acid, were tested for their genotoxic potential in cultured…”
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Rapid assay of intrinsic radiosensitivity based on apoptosis in human CD4 and CD8 T-lymphocytes by Ozsahin, M, Ozsahin, H, Shi, Y, Larsson, B, Würgler, F E, Crompton, N E

“…An assay for radiosensitivity has numerous applications in the clinic. Avoidance of acute responses, prediction of normal tissue toxicity, and…”
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Heterologous expression of human microsomal epoxide hydrolase in Saccharomyces cerevisiae. Study of the valpromide-carbamazepine epoxide interaction by Eugster, H P, Sengstag, C, Hinnen, A, Meyer, U A, Würgler, F E

“…A cDNA of human microsomal epoxide hydrolase (hmEH) was constitutively and inducibly expressed in Saccharomyces cerevisiae. The heterologous enzyme was located…”
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Reversible inhibition of mammalian tubulin assembly in vitro and effects in Saccharomyces cerevisiae D61.M by mitomycin C by Albertini, S, Friederich, U, Würgler, F E

“…Gaulden reported a novel and unexpected mitomycin C (MMC) effect, namely a pronounced retardation of very late prophase and loss of chromosome orientation in…”
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Metabolism of promutagens catalyzed by Drosophila melanogaster CYP6A2 enzyme in Saccharomyces cerevisiae by Saner, Catherine, Weibel, Beatrice, Würgler, Friedrich E., Sengstag, Christian

“…The somatic mutation and recombination test (SMART) in Drosophila melanogaster allows screening of chemicals for genotoxicity in a multicellular organism. In…”
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Environmental effects of genotoxins (eco-genotoxicology) by Würgler, F E, Kramers, P G

“…Genotoxic chemicals can damage the genetic material of humans as well as that of organisms living in the environment. With respect to adverse effects,…”
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Aristolochic acid is mutagenic and recombinogenic in Drosophila genotoxicity tests by Frei, H, Wurgler, F.E, Juon, H, Hall, C.B, Graf, U

“…Aristolochic acid (AA) has been tested for genotoxic activity in three different assays with Drosophila melanogaster (i-iii). AA induced sex-linked recessive…”
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Salmonella/mammalian microsome assay with tetranitromethane and 3-nitro-L-tyrosine by Würgler, F E, Friederich, U, Fürer, E, Ganss, M

“…The nitrosating agent tetranitromethane (TNM) and the nitrosation product 3-nitro-L-tyrosine (NT) were tested for mutagenic activity in the…”
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Somatic mutation and recombination test in Drosophila melanogaster by Graf, U, Würgler, F E, Katz, A J, Frei, H, Juon, H, Hall, C B, Kale, P G

“…A novel test system for the detection of mutagenic and recombinogenic activity of chemicals is described in detail. Drosophila melanogaster larvae…”
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Structure/activity relationships of the genotoxic potencies of sixteen pyrrolizidine alkaloids assayed for the induction of somatic mutation and recombination in wing cells of Drosophila melanogaster by Frei, H, Lüthy, J, Brauchli, J, Zweifel, U, Würgler, F E, Schlatter, C

“…Sixteen pyrrolizidine alkaloids (PAs) were examined for their genotoxic potency in the wing spot test of Drosophila melanogaster following oral application…”
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Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster by Frei, Hansjörg, Würgler, Friedrich E.

“…Four inhibitors of eukaryotic topoisomerases were investigated for genotoxic effects in the wing spot test of Drosophila melanogaster. As a somatic mutation…”
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Detection of genotoxic activity in native hospital waste water by the umuC test by Giuliani, Francesca, Koller, Theo, Würgler, F.E., Widmer, Rosa Maria

“…The genotoxic potential of the waste water of a hospital was evaluated by the umuC test. Within 2 years over 800 native waste water samples were analysed…”
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Distinct area distribution differences of micronuclei induced by clastogenic and aneuploidogenic chemicals in the bone marrow of the CD-1 mouse by Schneider, B.M., Würgler, F.E., Romagna, F.

“…To distinguish between aneuploidogenic and clastogenic effects of test chemicals, area distributions of micronuclei (MN) in polychromatic erythrocytes (PE)…”
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The somatic white-ivory eye spot test does not detect the same spectrum of genotoxic events as the wing somatic mutation and recombination test in Drosophila melanogaster by Graf, Ulrich, Würgler, Friedrich E.

“…A group of six chemical compounds was tested in parallel in two different somatic genotoxicity assays in Drosophila melanogaster, the wing somatic mutation and…”
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The vicinal chloroalcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) are not genotoxic in vivo in the wing spot test of Drosophila melanogaster by Frei, Hansjörg, Würgler, Friedrich E

“…In this study, the vicinal chloroalcohols 1,3-dichloro-2-propanol (DC2P), 3-chloro-1,2-propanediol (3CPD) and 2-chloro-1,3-propanediol (2CPD) were investigated…”
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Phenobarbital induces aneuploidy in Saccharomyces cerevisiae and stimulates the assembly of porcine brain tubulin by Albertini, S, Friederich, U, Gröschel-Stewart, U, Zimmermann, F K, Würgler, F E

“…Phenobarbital (PB) specifically induces mitotic chromosomal malsegregation in the diploid Saccharomyces cerevisiae strain D61.M but no other genetic events…”
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Inhibition of cytochrome P4501A by organotins in fish hepatoma cells PLHC-1 by Bruschweiler, B.J. (EAWAG, Dubendorf, Switzerland.), Wurgler, F.E, Fent, K

“…Inhibitory effects of several organotin compounds on cytochrome P4501A (CYP1A) induction response and enzyme activity have been analyzed in fish hepatoma cells…”
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