Search Results - "Wünsch, Désirée"

Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes by Kiweler, Nicole, Wünsch, Désirée, Wirth, Matthias, Mahendrarajah, Nisintha, Schneider, Günter, Stauber, Roland H., Brenner, Walburgis, Butter, Falk, Krämer, Oliver H.

“…Purpose We set out to determine whether clinically tested epigenetic drugs against class I histone deacetylases (HDACs) affect hallmarks of the metastatic…”
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Is small smarter? Nanomaterial-based detection and elimination of circulating tumor cells: current knowledge and perspectives by Gribko, Alena, Künzel, Julian, Wünsch, Désirée, Lu, Qiang, Nagel, Sophie Madeleine, Knauer, Shirley K, Stauber, Roland H, Ding, Guo-Bin

“…Circulating tumor cells (CTCs) are disseminated cancer cells. The occurrence and circulation of CTCs seem key for metastasis, still the major cause of…”
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Expressional analysis of disease-relevant signalling-pathways in primary tumours and metastasis of head and neck cancers by Goesswein, Dorothee, Habtemichael, Negusse, Gerhold-Ay, Aslihan, Mazur, Johanna, Wünsch, Désirée, Knauer, Shirley K., Künzel, Julian, Matthias, Christoph, Strieth, Sebastian, Stauber, Roland H.

“…Head and neck squamous cell carcinoma (HNSCC) often metastasize to lymph nodes resulting in poor prognosis for patients. Unfortunately, the underlying…”
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An Old Flame Never Dies: Survivin in Cancer and Cellular Senescence by Unruhe, Britta, Schröder, Elisabeth, Wünsch, Désirée, Knauer, Shirley K

“…Survivin (BIRC5) is highly expressed in the vast majority of human cancers and is associated with chemotherapy resistance, increased tumor recurrence and…”
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Disease-relevant signalling-pathways in head and neck cancer: Taspase1’s proteolytic activity fine-tunes TFIIA function by Gribko, Alena, Hahlbrock, Angelina, Strieth, Sebastian, Becker, Sven, Hagemann, Jan, Deichelbohrer, Max, Hildebrandt, Andreas, Habtemichael, Negusse, Wünsch, D.

“…Head and neck cancer (HNC) is the seventh most common malignancy in the world and its prevailing form, the head and neck squamous cell carcinoma (HNSCC), is…”
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Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy by Siemer, Svenja, Wünsch, Désirée, Khamis, Aya, Lu, Qiang, Scherberich, Arnaud, Filippi, Miriam, Krafft, Marie Pierre, Hagemann, Jan, Weiss, Carsten, Ding, Guo-Bin, Stauber, Roland H, Gribko, Alena

“…Nanomaterials have great potential for the prevention and treatment of cancer. Circulating tumor cells (CTCs) are cancer cells of solid tumor origin entering…”
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Quantitative profiling of the protein coronas that form around nanoparticles by Docter, Dominic, Distler, Ute, Storck, Wiebke, Kuharev, Jörg, Wünsch, Desirée, Hahlbrock, Angelina, Knauer, Shirley K, Tenzer, Stefan, Stauber, Roland H

“…When a nanoparticle enters the bloodstream, proteins bind to it to form a corona that may affect its function. This protein corona can be investigated using…”
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Staging of oropharyngeal squamous cell carcinoma of the head and neck: Prognostic features and power of the 8th edition of the UICC staging manual by Beltz, Anna, Gösswein, Dorothée, Zimmer, Stefanie, Limburg, Ivonne, Wünsch, Desirée, Gribko, Alena, Deichelbohrer, Maximilian, Hagemann, Jan, Stauber, Roland H., Künzel, Julian

“…Recognizing the prognostic power differentiating HPV-associated oropharyngeal squamous cell cancer (OPSCC) from OPSCC with other causes, the UICC Cancer…”
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Early Alterations of Endothelial Nitric Oxide Synthase Expression Patterns in the Guinea Pig Cochlea After Noise Exposure by Heinrich, Ulf R., Schmidtmann, Irene, Meuser, Regina, Ernst, Benjamin P., Wünsch, Desiree, Siemer, Svenja, Gribko, Alena, Stauber, Roland H., Strieth, Sebastian

“…Constitutively expressed endothelial nitric oxide synthase (eNOS) is supposed to play a role in noise-induced nitric oxide (NO)-production. It is commonly…”
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Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells by Bier, Carolin, Hecht, Rouven, Kunst, Lena, Scheiding, Sabine, Wünsch, Désirée, Goesswein, Dorothée, Schneider, Günter, Krämer, Oliver H, Knauer, Shirley K, Stauber, Roland H

“…The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes…”
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Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics by Siemer, Svenja, Westmeier, Dana, Barz, Matthias, Eckrich, Jonas, Wünsch, Désirée, Seckert, Christof, Thyssen, Christian, Schilling, Oliver, Hasenberg, Mike, Pang, Chengfang, Docter, Dominic, Knauer, Shirley K., Stauber, Roland H., Strieth, Sebastian

“…Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus investigated as novel antibacterial agents for clinical practice,…”
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Nanomedical detection and downstream analysis of circulating tumor cells in head and neck patients by Künzel, Julian, Gribko, Alena, Lu, Qiang, Stauber, Roland H, Wünsch, Désirée

“…The establishment of novel biomarkers in liquid biopsies of cancer patients has come more into focus in prognostic and diagnostic research efforts. Due to…”
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Corrigendum to “Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics” [Biomaterials 192 (2019) 551–559] by Siemer, Svenja, Westmeier, Dana, Barz, Matthias, Eckrich, Jonas, Wünsch, Désirée, Seckert, Christof, Thyssen, Christian, Schilling, Oliver, Hasenberg, Mike, Pang, Chengfang, Docter, Dominic, Knauer, Shirley K., Stauber, Roland H., Strieth, Sebastian

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Cleaving for growth: threonine aspartase 1—a protease relevant for development and disease by Stauber, Roland H., Hahlbrock, Angelina, Knauer, Shirley K., Wünsch, Désirée

“…From the beginning of life, proteases are key to organismal development comprising morphogenesis, cellular differentiation, and cell growth. Regulated…”
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Threonine Aspartase1: An unexplored protease with relevance for oral oncology? by Hahlbrock, Angelina, Goesswein, Dorothee, Künzel, Julian, Wünsch, Désirée, Stauber, Roland H

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Fly versus man: evolutionary impairment of nucleolar targeting affects the degradome of Drosophila's Taspase1 by Wünsch, Désirée, Hahlbrock, Angelina, Heiselmayer, Christina, Bäcker, Sandra, Heun, Patrick, Goesswein, Dorothee, Stöcker, Walter, Schirmeister, Tanja, Schneider, Günter, Krämer, Oliver H., Knauer, Shirley K., Stauber, Roland H.

“…ABSTRACT Human Taspase1 is essential for development and cancer by processing critical regulators, such as the mixed‐lineage leukemia protein. Likewise, its…”
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Allosteric inhibition of Taspase1's pathobiological activity by enforced dimerization in vivo by Bier, Carolin, Knauer, Shirley K, Wünsch, Désirée, Kunst, Lena, Scheiding, Sabine, Kaiser, Markus, Ottmann, Christian, Krämer, Oliver H, Stauber, Roland H

“…Taspase1 mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia-provoking MLL fusions and promotes solid malignancies. Currently, no…”
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Evolutionary divergence of Threonine Aspartase1 leads to species-specific substrate recognition by Wünsch, Désirée, Hahlbrock, Angelina, Heiselmayer, Christina, Bäcker, Sandra, Schrenk, Christian, Benne, Franziska, Schilling, Oliver, Knauer, Shirley K

“…Proteases are key regulators of life. Human Threonine Aspartase1 processes substrates, such as the mixed-lineage leukemia (MLL) protein, containing two…”
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Allosteric inhibition of Taspase1′s pathobiological activity by enforced dimerization in vivo by Bier, Carolin, Knauer, Shirley K., Wünsch, Désirée, Kunst, Lena, Scheiding, Sabine, Kaiser, Markus, Ottmann, Christian, Krämer, Oliver H., Stauber, Roland H.

“…ABSTRACT Taspase1 mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia‐provoking MLL fusions and promotes solid malignancies. Currently,…”
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Overexpression of the Catalytically Impaired Taspase1.sup.T234V or Taspase1.sup.D233A Variants Does Not Have a Dominant Negative Effect in T by Bier, Carolin, Hecht, Rouven, Kunst, Lena, Scheiding, Sabine, Wünsch, Désirée, Goesswein, Dorothée, Schneider, Günter, Krämer, Oliver H, Knauer, Shirley K, Stauber, Roland H

“…Background The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4*MLL…”
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