Search Results - "Wörner, Tobias P."

Adeno-associated virus capsid assembly is divergent and stochastic by Wörner, Tobias P., Bennett, Antonette, Habka, Sana, Snijder, Joost, Friese, Olga, Powers, Thomas, Agbandje-McKenna, Mavis, Heck, Albert J. R.

“…Adeno-associated viruses (AAVs) are increasingly used as gene therapy vectors. AAVs package their genome in a non-enveloped T  = 1 icosahedral capsid of ~3.8…”
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Expanding Differential Ion Mobility Separations into the MegaDalton Range by Wörner, Tobias P., Thurman, Hayden A., Makarov, Alexander A., Shvartsburg, Alexandre A.

“…Along with mass spectrometry (MS), ion mobility separations (IMS) are advancing to ever larger biomolecules. The emergence of electrospray ionization (ESI) and…”
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Bacterial encapsulins as orthogonal compartments for mammalian cell engineering by Sigmund, Felix, Massner, Christoph, Erdmann, Philipp, Stelzl, Anja, Rolbieski, Hannes, Desai, Mitul, Bricault, Sarah, Wörner, Tobias P., Snijder, Joost, Geerlof, Arie, Fuchs, Helmut, Hrabĕ de Angelis, Martin, Heck, Albert J. R., Jasanoff, Alan, Ntziachristos, Vasilis, Plitzko, Jürgen, Westmeyer, Gil G.

“…We genetically controlled compartmentalization in eukaryotic cells by heterologous expression of bacterial encapsulin shell and cargo proteins to engineer…”
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Assessment of genome packaging in AAVs using Orbitrap-based charge-detection mass spectrometry by Wörner, Tobias P., Snijder, Joost, Friese, Olga, Powers, Thomas, Heck, Albert J.R.

“…Adeno-associated viruses (AAVs) represent important gene therapy vectors with several approved clinical applications and numerous more in clinical trials…”
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Ultralong transients enhance sensitivity and resolution in Orbitrap-based single-ion mass spectrometry by Deslignière, Evolène, Yin, Victor C., Ebberink, Eduard H. T. M., Rolland, Amber D., Barendregt, Arjan, Wörner, Tobias P., Nagornov, Konstantin O., Kozhinov, Anton N., Fort, Kyle L., Tsybin, Yury O., Makarov, Alexander A., Heck, Albert J. R.

“…Orbitrap-based charge detection mass spectrometry utilizes single-molecule sensitivity to enable mass analysis of even highly heterogeneous, high-mass…”
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Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry by Wörner, Tobias P., Snijder, Joost, Bennett, Antonette, Agbandje-McKenna, Mavis, Makarov, Alexander A., Heck, Albert J. R.

“…We demonstrate single-particle charge detection mass spectrometry on an Orbitrap for the analysis of megadalton biomolecular assemblies. We establish that the…”
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Complete and cooperative in vitro assembly of computationally designed self-assembling protein nanomaterials by Wargacki, Adam J., Wörner, Tobias P., van de Waterbeemd, Michiel, Ellis, Daniel, Heck, Albert J. R., King, Neil P.

“…Recent advances in computational methods have enabled the predictive design of self-assembling protein nanomaterials with atomic-level accuracy. These design…”
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Mass Spectrometry-Based Structural Virology by Wörner, Tobias P, Shamorkina, Tatiana M, Snijder, Joost, Heck, Albert J R

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Frequency chasing of individual megadalton ions in an Orbitrap analyser improves precision of analysis in single-molecule mass spectrometry by Wörner, Tobias P., Aizikov, Konstantin, Snijder, Joost, Fort, Kyle L., Makarov, Alexander A., Heck, Albert J. R.

“…To enhance the performance of charge-detection mass spectrometry, we investigated the behaviour of macromolecular single ions on their paths towards and within…”
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Mild Acid Elution and MHC Immunoaffinity Chromatography Reveal Similar Albeit Not Identical Profiles of the HLA Class I Immunopeptidome by Sturm, Theo, Sautter, Benedikt, Wörner, Tobias P, Stevanović, Stefan, Rammensee, Hans-Georg, Planz, Oliver, Heck, Albert J. R, Aebersold, Ruedi

“…To understand and treat immunology-related diseases, a comprehensive, unbiased characterization of major histocompatibility complex (MHC) peptide ligands is of…”
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To 200,000 m/z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes by Le Huray, Kyle I. P., Wörner, Tobias P., Moreira, Tiago, Dembek, Marcin, Reinhardt-Szyba, Maria, Devine, Paul W. A., Bond, Nicholas J., Fort, Kyle L., Makarov, Alexander A., Sobott, Frank

“…Great progress has been made in the detection of large biomolecular analytes by native mass spectrometry; however, characterizing highly heterogeneous samples…”
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Site‐specific functionality and tryptophan mimicry of lipidation in tetraspanin CD9 by Neviani, Viviana, Deventer, Sjoerd, Wörner, Tobias P., Xenaki, Katerina T., Waterbeemd, Michiel, Rodenburg, Remco N. P., Wortel, Inge M. N., Kuiper, Jeroen K., Huisman, Sofie, Granneman, Joke, Bergen en Henegouwen, Paul M. P., Heck, Albert J. R., Spriel, Annemiek B., Gros, Piet

“…Lipidation of transmembrane proteins regulates many cellular activities, including signal transduction, cell–cell communication, and membrane trafficking…”
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