Search Results - "Wörheide, Maria A."

Multi-omics integration in biomedical research – A metabolomics-centric review by Wörheide, Maria A., Krumsiek, Jan, Kastenmüller, Gabi, Arnold, Matthias

“…Recent advances in high-throughput technologies have enabled the profiling of multiple layers of a biological system, including DNA sequence data (genomics),…”
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Mapping the proteo-genomic convergence of human diseases by Pietzner, Maik, Wheeler, Eleanor, Carrasco-Zanini, Julia, Cortes, Adrian, Koprulu, Mine, Wörheide, Maria A, Oerton, Erin, Cook, James, Stewart, Isobel D, Kerrison, Nicola D, Luan, Jian'an, Raffler, Johannes, Arnold, Matthias, Arlt, Wiebke, O'Rahilly, Stephen, Kastenmüller, Gabi, Gamazon, Eric R, Hingorani, Aroon D, Scott, Robert A, Wareham, Nicholas J, Langenberg, Claudia

“…Characterization of the genetic regulation of proteins is essential for understanding disease etiology and developing therapies. We identified 10,674 genetic…”
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Rare and common genetic determinants of metabolic individuality and their effects on human health by Surendran, Praveen, Stewart, Isobel D., Au Yeung, Victoria P. W., Pietzner, Maik, Raffler, Johannes, Wörheide, Maria A., Li, Chen, Smith, Rebecca F., Wittemans, Laura B. L., Bomba, Lorenzo, Menni, Cristina, Zierer, Jonas, Rossi, Niccolò, Sheridan, Patricia A., Watkins, Nicholas A., Mangino, Massimo, Hysi, Pirro G., Di Angelantonio, Emanuele, Falchi, Mario, Spector, Tim D., Soranzo, Nicole, Michelotti, Gregory A., Arlt, Wiebke, Lotta, Luca A., Denaxas, Spiros, Hemingway, Harry, Gamazon, Eric R., Howson, Joanna M. M., Wood, Angela M., Danesh, John, Wareham, Nicholas J., Kastenmüller, Gabi, Fauman, Eric B., Suhre, Karsten, Butterworth, Adam S., Langenberg, Claudia

“…Garrod’s concept of ‘chemical individuality’ has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput…”
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The landscape of metabolic brain alterations in Alzheimer's disease by Batra, Richa, Arnold, Matthias, Wörheide, Maria A., Allen, Mariet, Wang, Xue, Blach, Colette, Levey, Allan I., Seyfried, Nicholas T., Ertekin‐Taner, Nilüfer, Bennett, David A., Kastenmüller, Gabi, Kaddurah‐Daouk, Rima F., Krumsiek, Jan

“…Introduction Alzheimer's disease (AD) is accompanied by metabolic alterations both in the periphery and the central nervous system. However, so far, a global…”
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A proof of concept study towards multi‐omics‐based computational drug repositioning in Alzheimer’s disease by Wörheide, Maria A., Krumsiek, Jan, Kastenmüller, Gabi, Kaddurah‐Daouk, Rima F., Arnold, Matthias

“…Background Alzheimer’s disease (AD) is a devastating neurodegenerative disorder for which there currently are no disease‐modifying treatments available. To…”
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Plasma proteomic associations with genetics and health in the UK Biobank by Sun, Benjamin B., Chiou, Joshua, Traylor, Matthew, Benner, Christian, Hsu, Yi-Hsiang, Richardson, Tom G., Surendran, Praveen, Mahajan, Anubha, Robins, Chloe, Vasquez-Grinnell, Steven G., Hou, Liping, Kvikstad, Erika M., Burren, Oliver S., Davitte, Jonathan, Ferber, Kyle L., Gillies, Christopher E., Hedman, Åsa K., Hu, Sile, Lin, Tinchi, Mikkilineni, Rajesh, Pendergrass, Rion K., Pickering, Corran, Prins, Bram, Baird, Denis, Chen, Chia-Yen, Ward, Lucas D., Deaton, Aimee M., Welsh, Samantha, Willis, Carissa M., Lehner, Nick, Arnold, Matthias, Wörheide, Maria A., Suhre, Karsten, Kastenmüller, Gabi, Sethi, Anurag, Cule, Madeleine, Raj, Anil, Burkitt-Gray, Lucy, Melamud, Eugene, Black, Mary Helen, Fauman, Eric B., Howson, Joanna M. M., Kang, Hyun Min, McCarthy, Mark I., Nioi, Paul, Petrovski, Slavé, Scott, Robert A., Smith, Erin N., Szalma, Sándor, Waterworth, Dawn M., Mitnaul, Lyndon J., Szustakowski, Joseph D., Gibson, Bradford W., Miller, Melissa R., Whelan, Christopher D.

“…The Pharma Proteomics Project is a precompetitive biopharmaceutical consortium characterizing the plasma proteomic profiles of 54,219 UK Biobank participants…”
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Multi‐omics characterization of brain‐based pseudotime estimates for Alzheimer’s disease progression by Wörheide, Maria A., Batra, Richa, Krumsiek, Jan, Kaddurah‐Daouk, Rima F., Kastenmuller, Gabi, Arnold, Matthias

“…Background The cascade of molecular changes that leads to Alzheimer’s disease (AD) onset and progression remains incompletely understood. Recently, researchers…”
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Brain region‐specific metabolic signatures of Alzheimer’s disease by Batra, Richa, Krumsiek, Jan, Wang, Xue, Allen, Mariet, Wörheide, Maria A., Blach, Colette, Bennett, David A, Kastenmüller, Gabi, Arnold, Matthias, Ertekin‐Taner, Nilufer, Kaddurah‐Daouk, Rima

“…Background Metabolic dysregulation is one of the hallmarks of Alzheimer’s disease (AD). Alterations in metabolism have been associated with AD‐related…”
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