Search Results - "Vyoral, D"

Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using 55Fe and storage phosphorimaging by Krijt, M., Jirkovska, A., Kabickova, T., Melenovsky, V., Petrak, J., Vyoral, D.

“…Dysregulated iron metabolism has a detrimental effect on cardiac function. The importance of iron homeostasis in cardiac health and disease warrants detailed…”
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Proteomic analysis of imatinib-resistant CML-T1 cells reveals calcium homeostasis as a potential therapeutic target by Toman, O, Kabickova, T, Vit, O, Fiser, R, Polakova, K. Machova, Zach, J, Linhartova, J, Vyoral, D, Petrak, J

“…Chronic myeloid leukemia (CML) therapy has markedly improved patient prognosis after introduction of imatinib mesylate for clinical use. However, a subset of…”
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Accumulation of homoplasmic mtDNA point mutations in erythroblasts isolated from the bone marrow of patients with refractory anemia with ring sideroblasts (RARS) by Babusiaková, E, Vyoral, D, Neuwirtová, R, Sisková, M, Zeman, J, Kmoch, S

“…It was hypothesised that mitochondrial iron overload in patients with refractory anemia with ring sideroblasts (RARS) results from mitochondrial DNA (mtDNA)…”
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Lack of association between hemochromatosis and factor V Leiden mutations in the Czech population by Hrachovinova, I, Rypackova, B, Vyoral, D

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Hepcidin: A direct link between iron metabolism and immunity by Vyoral, Daniel, Petrák, Jiří

“…Hepcidin, originally discovered in urine as a bactericidal peptide synthesized by hepatocytes was later proved to be a key regulator of iron metabolism at the…”
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Hephaestin—a ferroxidase of cellular iron export by Petrak, Jiri, Vyoral, Daniel

“…Hephaestin is a transmembrane copper-dependent ferroxidase necessary for effective iron transport from intestinal enterocytes into the circulation. Hephaestin…”
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Detection and quantitation of iron in ferritin, transferrin and labile iron pool (LIP) in cardiomyocytes using 55 Fe and storage phosphorimaging by Krijt, M, Jirkovska, A, Kabickova, T, Melenovsky, V, Petrak, J, Vyoral, D

“…Dysregulated iron metabolism has a detrimental effect on cardiac function. The importance of iron homeostasis in cardiac health and disease warrants detailed…”
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Role of zinc in eukaryotic cells, zinc transporters and zinc-containing proteins. Review article by Fuchs, O, Babusiak, M, Vyoral, D, Petrák, J

“…As a catalytic and/or structural cofactor for countless of zinc-dependent enzymes and proteins, zinc is an essential element for all organisms. This review…”
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Proteomic analysis of iron overload in human hepatoma cells by Petrak, Jiri, Myslivcova, Denisa, Man, Petr, Cmejla, Radek, Cmejlova, Jana, Vyoral, Daniel

“…Iron-mediated organ damage is common in patients with iron overload diseases, namely, hereditary hemochromatosis. Massive iron deposition in parenchymal…”
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Different expression pattern of hepcidin genes in the liver and pancreas of C57BL/6N and DBA/2N mice by Krijt, Jan, Čmejla, Radek, Sýkora, Viktor, Vokurka, Martin, Vyoral, Daniel, Nečas, Emanuel

“…Male C57BL/6 and DBA/2 mice differ in their liver iron content. The aim of this study was to examine possible differences in the expression of hepcidin genes (…”
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Identification of heme binding protein complexes in murine erythroleukemic cells: Study by a novel two-dimensional native separation - liquid chromatography and electrophoresis by Babusiak, Marek, Man, Petr, Sutak, Robert, Petrak, Jiri, Vyoral, Daniel

“…In the current postgenomic era there is a growing interest in analysis of protein complexes in their native state. Here we present a novel two‐dimensional…”
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Distribution of Iron in Reticulocytes After Inhibition of Heme Synthesis With Succinylacetone: Examination of the Intermediates Involved in Iron Metabolism by Richardson, Des R., Ponka, Prem, Vyoral, Daniel

“…Succinylacetone (SA) is an inhibitor of heme synthesis that acts on the enzyme δ-aminolevulinic acid dehydratase. When reticulocytes are incubated with…”
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Proteomic Analysis of In Vitro Erythroid Differentiation by Petrak, J, Babusiak, M, Vyoral, D

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Incorporation of iron into Tritrichomonas foetus cell compartments reveals ferredoxin as a major iron-binding protein in hydrogenosomes by Suchan, Pavel, Vyoral, Daniel, Petrak, Jiri, Sut'ak, Robert, Rasoloson, Dominique, Nohynkova, Eva, Dolezal, Pavel, Tachezy, Jan

“…1 Department of Parasitology, Faculty of Science, Charles University, Vini ná 7, 128 44, Prague 2, Czech Republic 2 Institute of Hematology and Blood…”
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Detection of iron-containing proteins contributing to the cellular labile iron pool by a native electrophoresis metal blotting technique by Petrák, Jiřı́, Vyoral, Daniel

“…The labile iron pool (LIP) plays a role in generation of free radicals and is thus the target of chelators used for the treatment of iron overload. We have…”
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Detection and quantitation of 59Fe-labeled proteins using storage phosphorimaging by Vyoral, D, Petrák, J

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Iron transport in K562 cells: a kinetic study using native gel electrophoresis and 59Fe autoradiography by Vyoral, D, Petrák, J

“…The exact mechanisms of iron transport from endosomes to the target iron containing cellular proteins are currently unknown. To investigate this problem, we…”
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Separation of cellular iron containing compounds by electrophoresis by Vyoral, D, Petrák, J, Hradilek, A

“…High resolution separation of metalloproteins and other iron compounds based on native gel electrophoresis followed by 59Fe autoradiography is described…”
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Transferrin and iron distribution in subcellular fractions of K562 cells in the early stages of transferrin endocytosis by Vyoral, D, Hradilek, A, Neuwirt, J

“…Iron distribution in subcellular fractions was investigated at different times after a single cohort of 59Fe-125 I-labeled transferrin (Tf) endocytosis in K562…”
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Native electrophoretic separation and femtomolar detection of 65Zn-containing proteins by storage phosphorimaging by Vyoral, Daniel, Babušiak, Marek, Fuchs, Ota, Petrák, Jiřı&#x0301

“…Over 300 zinc-containing proteins have been described and over 1000 genes in the human genome encode proteins with zinc finger domains. Despite the important…”
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