Search Results - "Vynios, Demitrios H"
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A guide to the composition and functions of the extracellular matrix
Published in The FEBS journal (01-12-2021)“…Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that provides structural support for the cells and tissues. Accumulated…”
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Tumor-suppressive functions of 4-MU on breast cancer cells of different ER status: Regulation of hyaluronan/HAS2/CD44 and specific matrix effectors
Published in Matrix biology (01-05-2019)“…The malignant phenotype of various cancers is linked to enhanced expression of hyaluronan, a pro-angiogenic glycosaminoglycan whose expression is suppressed by…”
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Lumican effectively regulates the estrogen receptors-associated functional properties of breast cancer cells, expression of matrix effectors and epithelial-to-mesenchymal transition
Published in Scientific reports (23-03-2017)“…Lumican is a small leucine-rich proteoglycan that has been shown to contribute in several physiological processes, but also to exert anticancer activity. On…”
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Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics
Published in Food and chemical toxicology (01-05-2016)“…Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a…”
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Syndecans as modulators and potential pharmacological targets in cancer progression
Published in Frontiers in oncology (01-01-2014)“…Extracellular matrix (ECM) components form a dynamic network of key importance for cell function and properties. Key macromolecules in this interplay are…”
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The role of heparins and nano-heparins as therapeutic tool in breast cancer
Published in Glycoconjugate journal (01-06-2017)“…Glycosaminoglycans are integral part of the dynamic extracellular matrix (ECM) network that control crucial biochemical and biomechanical signals required for…”
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ADAMTS expression in colorectal cancer
Published in PloS one (18-03-2015)“…ADAMTSs are a family of secreted proteinases that share the metalloproteinase domain with matrix metalloproteinases (MMPs). By acting on a large panel of…”
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Involvement of hyaluronidases in colorectal cancer
Published in BMC cancer (17-09-2010)“…Hyaluronidases belong to a class of enzymes that degrade, predominantly, hyaluronan. These enzymes are known to be involved in physiological and pathological…”
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A guide to hyaluronan and related enzymes in breast cancer: biological significance and diagnostic value
Published in The FEBS journal (01-08-2019)“…Hyaluronan (HA) is a unique nonsulfated glycosaminoglycan that contributes to breast cancer cells growth and functional properties, including cell migration,…”
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Steviol glycosides affect functional properties and macromolecular expression of breast cancer cells
Published in IUBMB life (01-10-2022)“…Steviol glycosides, the active sweet components of stevia plant, have been recently found to possess a number of therapeutic properties, including some…”
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11
Evaluation of lumican effects on morphology of invading breast cancer cells, expression of integrins and downstream signaling
Published in The FEBS journal (01-11-2020)“…The small leucine‐rich proteoglycan lumican regulates estrogen receptors (ERs)‐associated functional properties of breast cancer cells, expression of matrix…”
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12
Altered content composition and structure of glycosaminoglycans and proteoglycans in gastric carcinoma
Published in The international journal of biochemistry & cell biology (01-03-2003)“…Glycosaminoglycans (GAGs) in proteoglycan (PG) forms or as free GAGs are implicated in the growth and progression of malignant tumors. These macromolecules…”
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Metabolism of Cartilage Proteoglycans in Health and Disease
Published in BioMed research international (01-01-2014)“…Cartilage proteoglycans are extracellular macromolecules with complex structure, composed of a core protein onto which a variable number of glycosaminoglycan…”
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Biochemical Changes of Extracellular Proteoglycans in Squamous Cell Laryngeal Carcinoma
Published in Connective Tissue Research (01-01-2008)“…Larynx is a complicated organ with peculiar properties, having a noticeable impact in vocal and respiratory physiology. In squamous cell laryngeal carcinoma,…”
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15
Biomechanical and structural changes following the decellularization of bovine pericardial tissues for use as a tissue engineering scaffold
Published in Journal of materials science. Materials in medicine (01-06-2012)“…To achieve natural scaffolds for tissue engineering applications we decellularized bovine pericardial (BP) tissues according to two different protocols: a…”
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Alterations of glycosaminoglycan disaccharide content and composition in colorectal cancer: Structural and expressional studies
Published in Oncology reports (01-08-2009)“…The glycosaminoglycans are implicated in many processes important in the growth and progression of malignant tumors. In the present study glycosaminoglycans…”
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Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer
Published in Molecular medicine reports (01-03-2011)“…Glycosaminoglycans undergo significant structural alterations in cancer, namely in terms of their sulfation pattern and hydrodynamic size. Numerous studies…”
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The structural and compositional changes of glycosaminoglycans are closely associated with tissue type in human laryngeal cancer
Published in Biochimie (01-12-2007)“…Hyaluronan and sulfated glycosaminoglycans, as intrinsic components of proteoglycans, are playing important roles in cancer biology. In the present study, we…”
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Enzymatic production of glucose from waste paper
Published in Bioresources (01-05-2009)“…Municipal wastes have become a severe problem in developed and developing countries during the last century, paper being the main constituent. Not all of the…”
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Matrix proteoglycans are markedly affected in advanced laryngeal squamous cell carcinoma
Published in Biochimica et biophysica acta (28-06-2004)“…Proteoglycans (PGs) are implicated in the growth and progression of malignant tumors. In this study, we examined the concentration and localization of PGs in…”
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