Search Results - "Vykunta, Vivasvan S"

CRISPR–Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells by Lin-Shiao, Enrique, Pfeifer, Wolfgang G, Shy, Brian R, Saffari Doost, Mohammad, Chen, Evelyn, Vykunta, Vivasvan S, Hamilton, Jennifer R, Stahl, Elizabeth C, Lopez, Diana M, Sandoval Espinoza, Cindy R, Deyanov, Alexander E, Lew, Rachel J, Poirer, Michael G, Marson, Alexander, Castro, Carlos E, Doudna, Jennifer A

“…Abstract DNA nanostructures are a promising tool to deliver molecular payloads to cells. DNA origami structures, where long single-stranded DNA is folded into…”
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High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-molecule cocktails by Shy, Brian R., Vykunta, Vivasvan S., Ha, Alvin, Talbot, Alexis, Roth, Theodore L., Nguyen, David N., Pfeifer, Wolfgang G., Chen, Yan Yi, Blaeschke, Franziska, Shifrut, Eric, Vedova, Shane, Mamedov, Murad R., Chung, Jing-Yi Jing, Li, Hong, Yu, Ruby, Wu, David, Wolf, Jeffrey, Martin, Thomas G., Castro, Carlos E., Ye, Lumeng, Esensten, Jonathan H., Eyquem, Justin, Marson, Alexander

“…Enhancing CRISPR-mediated site-specific transgene insertion efficiency by homology-directed repair (HDR) using high concentrations of double-stranded DNA…”
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Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies by Goodman, Daniel B, Azimi, Camillia S, Kearns, Kendall, Talbot, Alexis, Garakani, Kiavash, Garcia, Julie, Patel, Nisarg, Hwang, Byungjin, Lee, David, Park, Emily, Vykunta, Vivasvan S, Shy, Brian R, Ye, Chun Jimmie, Eyquem, Justin, Marson, Alexander, Bluestone, Jeffrey A, Roybal, Kole T

“…Chimeric antigen receptors (CARs) repurpose natural signaling components to retarget T cells to refractory cancers but have shown limited efficacy in…”
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Altered cancer metabolism and implications for next-generation CAR T-cell therapies by Ramapriyan, Rishab, Vykunta, Vivasvan S., Vandecandelaere, Gust, Richardson, Leland G.K., Sun, Jing, Curry, William T., Choi, Bryan D.

“…This review critically examines the evolving landscape of chimeric antigen receptor (CAR) T-cell therapy in treating solid tumors, with a particular focus on…”
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Molecular basis for potent B cell responses to antigen displayed on particles of viral size by Brooks, Jeremy F., Riggs, Julianne, Mueller, James L., Mathenge, Raisa, Wholey, Wei-Yun, Meyer, Alexander R., Yoda, Sekou-Tidiane, Vykunta, Vivasvan S., Nielsen, Hailyn V., Cheng, Wei, Zikherman, Julie

“…Multivalent viral epitopes induce rapid, robust and T cell-independent humoral immune responses, but the biochemical basis for such potency remains…”
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Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes by Foss, Dana V., Muldoon, Joseph J., Nguyen, David N., Carr, Daniel, Sahu, Srishti U., Hunsinger, John M., Wyman, Stacia K., Krishnappa, Netravathi, Mendonsa, Rima, Schanzer, Elaine V., Shy, Brian R., Vykunta, Vivasvan S., Allain, Vincent, Li, Zhongmei, Marson, Alexander, Eyquem, Justin, Wilson, Ross C.

“…CRISPR-mediated genome editing of primary human lymphocytes is typically carried out via electroporation, which can be cytotoxic, cumbersome and costly. Here…”
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Mast cells help organize the Peyer's patch niche for induction of IgA responses by De Giovanni, Marco, Vykunta, Vivasvan S, Biram, Adi, Chen, Kevin Y, Taglinao, Hanna, An, Jinping, Sheppard, Dean, Paidassi, Helena, Cyster, Jason G

“…Peyer's patches (PPs) are lymphoid structures situated adjacent to the intestinal epithelium that support B cell responses that give rise to many intestinal…”
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