Search Results - "Vyas, Bhavin"
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Effect of gold nanoparticles on timolol uptake and its release kinetics from contact lenses: In vitro and in vivo evaluation
Published in Acta biomaterialia (01-03-2019)“…[Display omitted] Contact lenses are ideally suited for extended drug delivery to the ocular tissues, but incorporation of any particulate system affects the…”
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Design, Development, and Evaluation of SA-F127:TPGS Polymeric Mixed Micelles for Improved Delivery of Glipizide Drug: In-vitro, Ex-vivo, and In-vivo Investigations
Published in AAPS PharmSciTech (17-10-2023)“…The anti-diabetic glipizide (GLN) drug has notable pharmaceutical advantages, but poor aqueous solubility restricts its wide applications. The present work was…”
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In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery
Published in Journal of controlled release (28-03-2016)“…Glaucoma is commonly treated using eye drops, which is highly inefficient due to rapid clearance (low residence time) from ocular surface. Contact lenses are…”
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Impact of clinical pharmacist services on quality adjusted life years in head and neck cancer patients
Published in International journal of clinical pharmacy (01-10-2021)“…Background The role of clinical pharmacists in the provision of patient care is evolving in developing countries such as India. However, their acceptance in…”
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Proton pump inhibitors and osteoporosis risk: exploring the role of TRPM7 channel
Published in European journal of clinical pharmacology (2022)“…Background Long-term use of proton pump inhibitors (PPIs) has been linked to an increased risk of osteoporosis, with various indirect mechanisms so far…”
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Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: Optimization and in vivo pharmacokinetic studies
Published in International journal of pharmaceutics (01-05-2021)“…[Display omitted] Clozapine is widely used to treat schizophrenia as an atypical antipsychotic. Low solubility, poor dissolution rate, degradation in the…”
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Contact lenses with dual drug delivery for the treatment of bacterial conjunctivitis
Published in International journal of pharmaceutics (05-09-2018)“…Controlled drug release from semi-circular drug-loaded rings in the contact lenses. [Display omitted] Currently, bacterial conjunctivitis is treated by…”
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pH triggered controlled drug delivery from contact lenses: Addressing the challenges of drug leaching during sterilization and storage
Published in Colloids and surfaces, B, Biointerfaces (01-09-2017)“…pH triggered drug delivery from contact lenses [Display omitted] •PH triggered drug delivery using nanoparticle-laden contact lenses.•Overcome the limitation…”
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Effect of surfactant chain length on drug release kinetics from microemulsion-laden contact lenses
Published in International journal of pharmaceutics (30-05-2017)“…Investigation of surfactant chain length on release kinetics of drug from microemulsion-laden contact lenses [Display omitted] The effect of surfactant chain…”
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Design and optimization of a novel implantation technology in contact lenses for the treatment of dry eye syndrome: In vitro and in vivo evaluation
Published in Acta biomaterialia (15-04-2017)“…[Display omitted] Contact lenses are widely used for ophthalmic drug delivery, but incorporation of drug or formulation in the contact lenses affects its…”
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Impact of oncology pharmacist services on humanistic outcome in patients with breast cancer
Published in Journal of oncology pharmacy practice (01-03-2022)“…Objective This study aims to investigate the change in quality adjusted life-years (QALYs) after providing oncology pharmacist services to assess its impact on…”
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Effect of co-administration of metformin and extracts of Costus pictus D.Don leaves on alloxan-induced diabetes in rats
Published in Journal of Traditional and Complementary Medicine (01-05-2022)“…Background and aim: The present study evaluates the antidiabetic effects of aqueous (CPAQ) and methanolic (CPME) extract of Costus pictus D. Don singly and/or…”
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Clozapine-laden carbon dots delivered to the brain via an intranasal pathway: Synthesis, characterization, ex vivo, and in vivo studies
Published in Colloids and surfaces, B, Biointerfaces (01-05-2024)“…Clozapine, which is widely used to treat schizophrenia, shows low bioavailability due to poor solubility and high first-pass metabolism. The study aimed to…”
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Impact of cetuximab plus cisplatin alone and cetuximab plus cisplatin and paclitaxel regimen on humanistic outcome in head and neck cancer
Published in Journal of Egyptian National Cancer Institute (19-01-2023)“…The prevalence of head and neck cancer (HNC) is increasing rapidly, and the prognosis is poor in the advance stage. For the patient suffering from advance…”
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Lamotrigine loaded PLGA nanoparticles intended for direct nose to brain delivery in epilepsy: pharmacokinetic, pharmacodynamic and scintigraphy study
Published in Artificial cells, nanomedicine, and biotechnology (01-01-2021)“…The present study aimed to investigate the brain targeting efficacy of Lamotrigine (LTG) loaded PLGA nanoparticles (LTG-PNPs) upon intranasal administration…”
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Intranasal delivery of doxepin: enhancing brain targeting efficiency utilizing nanostructured lipid carriers for a biopharmaceutics drug disposition classification system class-I drug
Published in Pharmaceutical development and technology (02-07-2024)“…Doxepin, a Class-I Biopharmaceutics Drug Disposition Classification System (BDDCS) drug, exhibits poor bioavailability due to extensive first-pass metabolism…”
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Antiurolithiatic activity of saponin rich fraction from the fruits of Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) against ethylene glycol induced urolithiasis in rats
Published in Journal of ethnopharmacology (31-10-2012)“…A well-known traditional herb Solanum xanthocarpum is widely used in India for the management of different ailments including urolithiasis. This study was…”
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Repurposing of Iloperidone: Antihypertensive and ocular hypotensive activity in animals
Published in European journal of pharmaceutical sciences (15-02-2020)“…Iloperidone, second generation antipsychotic drug, reported in clinical trial to produce orthostatic hypotension as side effect. It was claimed to be…”
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Enhancement of in vivo hypoglycemic effect of gliclazide by developing self-microemulsifying pellet dosage form
Published in Future journal of pharmaceutical sciences (25-05-2020)“…Background The present research was aimed to develop a self-microemulsifying drug delivery system (SMEDDS) pellet to increase the dissolution rate and in vivo…”
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Multiple drug delivery from the drug-implants-laden silicone contact lens: Addressing the issue of burst drug release
Published in Materials Science & Engineering C (01-07-2020)“…A fixed combination of bimatoprost/timolol eye drop solution is used to manage the elevated intra-ocular pressure in glaucoma patients, including individuals…”
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