Search Results - "Vuylsteke, Ronald J."

Feasibility of flowcytometric quantitation of immune effector cell subsets in the sentinel lymph node of the breast after cryopreservation by van Pul, Kim M., Vuylsteke, Ronald J.C.L.M., Bril, Herman, Stockmann, Hein B.A.C., de Gruijl, Tanja D.

“…The sentinel lymph node (SLN) is an emerging focus for immunological research in breast cancer. Cryopreservation of SLN single-cell suspensions allows for…”
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Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway by van Pul, Kim M, Vuylsteke, Ronald J C L M, de Beijer, Monique T A, van de Ven, Rieneke, van den Tol, M Petrousjka, Stockmann, Hein B A C, de Gruijl, Tanja D

“…BackgroundWe previously showed selectively hampered activation of lymph node-resident (LNR) dendritic cell (DC) subsets in the breast cancer (BrC) sentinel…”
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Biological Mesh Closure of the Pelvic Floor After Extralevator Abdominoperineal Resection for Rectal Cancer: A Multicenter Randomized Controlled Trial (the BIOPEX-study) by Musters, Gijsbert D, Klaver, Charlotte E L, Bosker, Robbert J I, Burger, Jacobus W A, van Duijvendijk, Peter, van Etten, Boudewijn, van Geloven, Anna A W, de Graaf, Eelco J R, Hoff, Christiaan, Leijtens, Jeroen W A, Rutten, Harm J T, Singh, Baljit, Vuylsteke, Ronald J C L M, de Wilt, Johannes H W, Dijkgraaf, Marcel G W, Bemelman, Willem A, Tanis, Pieter J

“…To determine the effect of biological mesh closure on perineal wound healing after extralevator abdominoperineal resection (eAPR). Perineal wound complications…”
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Local administration of granulocyte/macrophage colony-stimulating factor increases the number and activation state of dendritic cells in the sentinel lymph node of early-stage melanoma by VUYLSTEKE, Ronald J. C. L. M, MOLENKAMP, Barbara G, GIETEMA, Hester A, VAN LEEUWEN, Paul A. M, WIJNANDS, Pepijn G. J. T. B, VOS, Wim, VAN DIEST, Paul J, SCHEPER, Rik J, MEIJER, Sybren, DE GRUIJL, Tanja D

“…The initial tumor-draining lymph node, the sentinel lymph node, not only constitutes the first expected site of micrometastasis but also the first point of…”
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In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma by Koster, Bas D., de Jong, Tamarah D., van den Hout, Mari F. C. M., Sluijter, Berbel J. R., Vuylsteke, Ronald J. C. L. M., Molenkamp, Barbara G., Vosslamber, Saskia, van den Tol, M. Petrousjka, van den Eertwegh, Alfons J. M., de Gruijl, Tanja D.

“…Whereas TLR9 agonists are recognized as powerful stimulators of antitumor immunity, GM-CSF has had mixed reviews. In previously reported randomized trials we…”
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Local Adjuvant Treatment with Low-Dose CpG-B Offers Durable Protection against Disease Recurrence in Clinical Stage I-II Melanoma: Data from Two Randomized Phase II Trials by Koster, Bas D, van den Hout, Mari F C M, Sluijter, Berbel J R, Molenkamp, Barbara G, Vuylsteke, Ronald J C L M, Baars, Arnold, van Leeuwen, Paul A M, Scheper, Rik J, Petrousjka van den Tol, M, van den Eertwegh, Alfons J M, de Gruijl, Tanja D

“…Although risk of recurrence after surgical removal of clinical stage I-II melanoma is considerable, there is no adjuvant therapy with proven efficacy. Here, we…”
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Cumulative 5-year Results of a Randomized Controlled Trial Comparing Biological Mesh With Primary Perineal Wound Closure After Extralevator Abdominoperineal Resection (BIOPEX-study) by Blok, Robin D., Sharabiany, Sarah, Stoker, Jaap, Laan, Ellen T. M., Bosker, Robbert J. I., Burger, Jacobus W. A., Chaudhri, Sanjay, van Duijvendijk, Peter, van Etten, Boudewijn, van Geloven, Anna A. W., de Graaf, Eelco J. R., Hoff, Christiaan, Hompes, Roel, Leijtens, Jeroen W. A., Rothbarth, Joost, Rutten, Harm J. T., Singh, Baljit, Vuylsteke, Ronald J. C. L. M., de Wilt, Johannes H. W., Dijkgraaf, Marcel G. W., Bemelman, Willem A., Musters, Gijsbert D., Tanis, Pieter J.

“…To determine long-term outcomes of a randomized trial (BIOPEX) comparing biological mesh and primary perineal closure in rectal cancer patients after…”
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Pattern and incidence of first site recurrences following sentinel node procedure in melanoma patients by Muller, Markwin G. Statius, van Leeuwen, Paul A. M., van Diest, Paul J., Pijpers, Rik, Nijveldt, Robert J., Vuylsteke, Ronald J. C. L. M., Meijer, Sybren

“…Studies of large series of melanoma patients indicated that the average incidence of developing a recurrence during follow‐up was 40%. The most frequent first…”
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Unpredictability of lymphatic drainage patterns in melanoma patients by MULLER, Markwin G, HENNIPMAN, Feitse A, VAN LEEUWEN, Paul A. M, PIJPERS, Rik, VUYLSTEKE, Ronald J. C. L. M, MEIJER, Sybren

“…We analysed the localisations of sentinel nodes (SN) found with the SN procedure to compare these sites with those that would have been predicted by…”
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Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node by van Pul, Kim M, Vuylsteke, Ronald J C L M, van de Ven, Rieneke, Te Velde, Elisabeth A, Rutgers, Emiel J Th, van den Tol, Petrousjka M, Stockmann, Hein B A C, de Gruijl, Tanja D

“…Immune regulated pathways influence both breast cancer (BrC) development and response to (neo)adjuvant chemotherapy. The sentinel lymph node (SLN), as the…”
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Sentinel lymph node tumor load: an independent predictor of additional lymph node involvement and survival in melanoma by Vuylsteke, Ronald J C L M, Borgstein, Paul J, van Leeuwen, Paul A M, Gietema, Hester A, Molenkamp, Barbara G, Statius Muller, Markwin G, van Diest, Paul J, van der Sijp, Joost R M, Meijer, Sybren

“…Even though 60% to 80% of melanoma patients with a positive sentinel lymph node (SLN) have no positive additional lymph nodes (ALNs), all these patients are…”
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Sampling Tumor-Draining Lymph Nodes for Phenotypic and Functional Analysis of Dendritic Cells and T Cells by Vuylsteke, Ronald J.C.L.M., van Leeuwen, Paul A.M., Meijer, Sybren, Wijnands, Pepijn G.J.T.B., Statius Muller, Markwin G., Busch, Dirk H., Scheper, Rik J., de Gruijl, Tanja D.

“…Immune responses against tumor antigens will initially occur in the first tumor-draining lymph node, the sentinel node (SN). Because of extensive diagnostic…”
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The sentinel lymph node status is an important factor for predicting clinical outcome in patients with Stage I or II cutaneous melanoma by Statius Muller, Markwin G., van Leeuwen, Paul A. M., de Lange‐de Klerk, Elly S. M, van Diest, Paul J., Pijpers, Rik, Ferwerda, Charlotte C., Vuylsteke, Ronald J. C. L. M., Meijer, Sybren

“…BACKGROUND In a cohort of patients, the authors investigated whether and to what extent the sentinel lymph node (SLN) status contributes to predicting the…”
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Randomized controlled multicentre study comparing biological mesh closure of the pelvic floor with primary perineal wound closure after extralevator abdominoperineal resection for rectal cancer (BIOPEX-study) by Musters, Gijsbert D, Bemelman, Willem A, Bosker, Robbert J I, Burger, Jacobus W A, van Duijvendijk, Peter, van Etten, Boudewijn, van Geloven, Anna A W, de Graaf, Eelco J R, Hoff, Christiaan, de Korte, Niels, Leijtens, Jeroen W A, Rutten, Harm J T, Singh, Baljit, van de Ven, Anthony, Vuylsteke, Ronald J C L M, de Wilt, Johannes H W, Dijkgraaf, Marcel G W, Tanis, Pieter J

“…Primary perineal wound closure after conventional abdominoperineal resection (cAPR) for rectal cancer has been the standard of care for many years. Since the…”
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Tumor-Specific CD8+ T Cell Reactivity in the Sentinel Lymph Node of GM-CSF–Treated Stage I Melanoma Patients is Associated with High Myeloid Dendritic Cell Content by VUYLSTEKE, Ronald J. C. L. M, MOLENKAMP, Barbara G, VAN LEEUWEN, Paul A. M, MEIJER, Sybren, WIJNANDS, Pepijn G. J. T. B, HAANEN, John B. A. G, SCHEPER, Rik J, DE GRUIJL, Tanja D

“…Purpose: Impaired immune functions in the sentinel lymph node (SLN) may facilitate early metastatic events during melanoma development. Local potentiation of…”
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Matched Skin and Sentinel Lymph Node Samples of Melanoma Patients Reveal Exclusive Migration of Mature Dendritic Cells by Molenkamp, Barbara G., Vuylsteke, Ronald J.C.L.M., van Leeuwen, Paul A.M., Meijer, Sybren, Vos, Wim, Wijnands, Pepijn G.J.T.B., Scheper, Rik J., de Gruijl, Tanja D.

“…Mature and immature myeloid dendritic cells (DCs) are thought to differentially modulate T-cell responses in secondary lymphoid tissues. Although mature DCs…”
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Preoperative granulocyte/macrophage colony-stimulating factor (GM-CSF) increases hepatic dendritic cell numbers and clustering with lymphocytes in colorectal cancer patients by Oosterling, Steven J., Mels, Anneke K., Geijtenbeek, Teunis B.H., van der Bij, Gerben J., Tuk, Cornelis W., Vuylsteke, Ronald J.C.L.M., van Leeuwen, Paul A.M., Meijer, Gerrit A., Meijer, Sybren, Beelen, Robert H.J., van Egmond, Marjolein

“…Despite surgery with curative intent, approximately 30% of colorectal carcinoma patients will develop liver metastases during follow-up. Synchronous occult…”
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Cumulative 5-year Results of a Randomized Controlled Trial Comparing Biological Mesh with Primary Perineal Wound Closure after Extralevator Abdominoperineal Resection (BIOPEX-study) by Blok, Robin D., Sharabiany, Sarah, Stoker, Jaap, Laan, Ellen T. M., Bosker, Robbert J. I., Burger, Jacobus W. A., Chaudhri, Sanjay, van Duijvendijk, Peter, van Etten, Boudewijn, van Geloven, Anna A. W., de Graaf, Eelco J. R., Hoff, Christiaan, Hompes, Roel, Leijtens, Jeroen W. A., Rothbarth, Joost, Rutten, Harm J. T., Singh, Baljit, Vuylsteke, Ronald J. C. L. M., de Wilt, Johannes H. W., Dijkgraaf, Marcel G. W., Bemelman, Willem A., Musters, Gijsbert D., Tanis, Pieter J.

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Optimised treatment of patients with enlarged lateral lymph nodes in rectal cancer: protocol of an international, multicentre, prospective registration study after extensive multidisciplinary training (LaNoReC) by Sluckin, Tania C, Intven, Martijn, Lange, Marilyne M, Taggart, Melissa W, Beets-Tan, Regina G H, Konishi, Tsuyoshi, Tanis, Pieter J, Kusters, Miranda, Geijsen, Elisabeth D., Hompes, Roel, Meijnen, Philip, Stoker, Jaap, Bruijnzeel, Ingrid M., Lamme, Bas, Alberts, Femke M., Crolla, Rogier M. P. H., Verdult, Joanne, van Kessel, Charlotte S., Mulder, Erik Jan, Hulshoff, Jan Binne, Cherepanin, Ivan M., Fabry, Hans F. J., Kemper, Frank J. M., Cnossen, Jeltsje S., Nederend, Joost, de Bie, Shira H., Bosker, Robbert J. I., Boogerd, Leonora S. F., Govaert, Marc J. P. M., Antonisse, Imogeen E., Rothbarth, Joost, Vries, Marianne de, Ribbert, Marcel A. H., Borg, Susan ter, Verseveld, Maria, de Korte, Fleur I., Marinelli, Andreas W. K. S., Westerterp, Marinke, Aukema, Tjeerd S., van Bockel, Liselotte W., van Tilborg, Aukje A. J. M., Rozema, Tom, Hoogendoorn, Stefan, Offerman, Saskia R., Vos, Hanneke, van Westreenen, Henderik L., Leijtens, Jeroen W. A., Peeters, Koen C.M.J., Velema, Laura A., Els, L, Meerten, van Persijn van, Bakers, Frans C. H., Šefčovičová, Nina, Berbée, Maaike, Rouw, Dennis B., René Arensman, L., Basart, Hanneke, Consten, Esther C. J., Verheijen, Paul M., Fassaert, Thomas A., Hoff, Christiaan, van Duyn, Eino B., Hendriksen, Ellen M., Grotenhuis, Brechtje A., van Geel, Anne M., Meischl, Christof, Hermien Schreurs, W., Spruit, Patty H., Gerhards, Michael F., Karsten, Thomas M., Peringa, Jan, Koeverden, Sebastiaan van, Bremers, Andre J. A., Rütten, Heidi, de Wilt, Johannes H. W., Hartogh, Mariska den, Muller, Karin, Oppedijk, Vera, Dekker, Jan Willem T., Eschbach-Zandbergen, Debora, Gerbrands, Krista, Roos, Daphne, Jan, Ernst, Knijn, Nikki, de Roos, Marnix A. J., Dop, Ilse van, Croft, Michael, Ruszkiewicz, Andrew, Wilks, Michael, Oosterling, Steven J., Tielbeek, Jeroen A. W., Vuylsteke, Ronald J. C. L. M., van der Hoeven, Erik J. R. J., Braat, Manon N. G. J. A., van Grevenstein, Wilhelmina M. U., Richir, Milan C., Leseman, Tilly, Belgers, Eric H. J., Krdzalic, Jasenko, Vliegen, Roy F. A.

“…IntroductionInadequate treatment of enlarged lateral lymph nodes (LLNs) in rectal cancer patients is associated with an increased lateral local recurrence…”
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Abstract 4692: Local adjuvant treatment of clinical stage I-II melanoma with low dose CpG-B and/or GM-CSF: Long-term follow-up of three randomized controlled phase II trials by Koster, Bas D., Hout, Mari F. van den, Sluijter, Berbel J., Molenkamp, Barbara G., Vuylsteke, Ronald J., Baars, Arnold, Leeuwen, Paul A. van, Scheper, Rik J., Tol, Monique P. van den, Eertwegh, Alfons J. van den, Gruijl, Tanja D. de

“…Abstract Introduction: Currently, there is no widely used adjuvant treatment available to improve survival after surgical excision of localized melanoma. Here,…”
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