Search Results - "Vuorio, E."

Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis by Morko, J P, Söderström, M, Säämänen, A-M K, Salminen, H J, Vuorio, E I

“…Objectives: To study the expression of cysteine proteinases, particularly cathepsin K, and their extracellular inhibitor cystatin C in articular cartilage of…”
Get full text

Role of cathepsin K in normal joints and in the development of arthritis by Salminen-Mankonen, H J, Morko, J, Vuorio, E

“…Cysteine cathepsins are a large family of proteolytic enzymes active at acidic pH as found in lysosomes. Since its discovery in 1990's, cathepsin K has been…”
Get more information

Differential expression patterns of matrix metalloproteinases and their inhibitors during development of osteoarthritis in a transgenic mouse model by Salminen, H J, Säämänen, A-M K, Vankemmelbeke, M N, Auho, P K, Perälä, M P, Vuorio, E I

“…Objective: To characterise the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) during degeneration of…”
Get full text

A metaphyseal defect model of the femur for studies of murine bone healing by Uusitalo, H, Rantakokko, J, Ahonen, M, Jämsä, T, Tuukkanen, J, KäHäri, V.-M, Vuorio, E, Aro, H.T

“…A bone defect model was developed in the distal metaphysis of the femur for studies on bone healing in the mouse. The circular defect involving 20% of the bone…”
Get full text

Differential turnover of cortical and trabecular bone in transgenic mice overexpressing cathepsin K by Morko, Jukka, Kiviranta, Riku, Hurme, Sara, Rantakokko, Juho, Vuorio, Eero

“…Cathepsin K is a major osteoclastic protease. We have recently shown that overexpression of mouse cathepsin K gene in transgenic UTU17 mouse model results in…”
Get full text

Gene expression during bone repair by Sandberg, M M, Aro, H T, Vuorio, E I

“…Detailed understanding of the basic events in fracture healing constitutes a foundation for the development of new approaches to stimulate bone healing. Since…”
Get more information

Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells by Kirschke, H., Eerola, R., Hopsu-Havu, V.K., Brömme, D., Vuorio, E.

“…Several tumour-forming cell lines are known to overproduce the lysosomal cysteine peptidase cathepsin L. We have used an antisense approach to investigate…”
Get full text

Bone defect repair in immobilization-induced osteopenia: a pQCT, biomechanical, and molecular biologic study in the mouse femur by Uusitalo, H., Rantakokko, J., Vuorio, E., Aro, H.T.

“…The present study was carried out to determine whether immobilization-induced (Im) osteopenic bone possesses the same reparative capacity as normal healthy…”
Get full text

Differential expression patterns of cathepsins B, H, K, L and S in the mouse ovary by Oksjoki, S., Söderström, M., Vuorio, E., Anttila, L.

“…Cathepsins B, H, K, L and S belong to a family of lysosomal cysteine proteinases which participate in a variety of proteolytic processes, including degradation…”
Get full text

Expression patterns of cathepsins B, H, K, L and S in the human endometrium by Jokimaa, V., Oksjoki, S., Kujari, H., Vuorio, E., Anttila, L.

“…Cathepsins B, H, K, L and S belong to the family of lysosomal cysteine proteinases and participate in a variety of proteolytic processes, including degradation…”
Get full text

Combined effect of BMP-2 gene transfer and bioactive glass microspheres on enhancement of new bone formation by Välimäki, V.-V., Yrjans, J. J., Vuorio, E., Aro, H. T.

“…Adenovirus‐mediated recombinant human BMP‐2 (RAdBMP‐2) gene transfer has been found to have significant osteoinductive properties. The hypothesis of the…”
Get full text

Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus by Uusitalo, H, Hiltunen, A, Söderström, M, Aro, H T, Vuorio, E

“…Fracture repair provides an interesting model for chondrogenesis and osteogenesis as it recapitulates in an adult organism the same steps encountered during…”
Get full text

Localization of Types I, II, and III Collagen mRNAs in Developing Human Skeletal Tissues by in situ Hybridization by Sandberg, Minna, Vuorio, Eero

“…Paraffin sections of human skeletal tissues were studied in order to identify cells responsible for production of types I, II, and III collagens by in situ…”
Get full text

Accelerated Up‐Regulation of L‐Sox5, Sox6, and Sox9 by BMP‐2 Gene Transfer During Murine Fracture Healing by Uusitalo, Hannele, Hiltunen, Ari, Ahonen, Matti, Gao, Tie‐Jun, Lefebvre, Veronique, Harley, Vincent, Kähäri, Veli‐Matti, Vuorio, Eero

“…Fracture repair is the best‐characterized situation in which activation of chondrogenesis takes place in an adult organism. To better understand the mechanisms…”
Get full text

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene by Säämänen, A.-M.K, Salminen, H.J, Dean, P.B, De Crombrugghe, B, Vuorio, E.I, Metsäranta, M.P.H

“…Objective The present study was conducted on transgenic Del1 (+/−) mice harboring six copies of a transgene with small deletion mutation engineered into mouse…”
Get full text

Differences in connective tissue gene expression between normally functioning, polycystic and post‐menopausal ovaries by Oksjoki, S., Rahkonen, O., Haarala, M., Vuorio, E., Anttila, L.

“…Arrested follicular maturation is a characteristic feature of polycystic ovary syndrome (PCOS). Follicles mature in ovarian stroma composed of extracellular…”
Get full text

Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice by Joronen, K, Ala-aho, R, Majuri, M-L, Alenius, H, Kähäri, V-M, Vuorio, E

“…Objectives: To better understand the role of collagenase-3 (MMP-13) in joint inflammation by investigating the consequences of transient overexpression of…”
Get full text

Silica-based bioactive glasses modulate expression of bone morphogenetic protein-2 mRNA in Saos-2 osteoblasts in vitro by Gao, Tiejun, Aro, Hannu T., Ylänen, Heimo, Vuorio, Eero

“…A chemical exchange of the silica gel layer forming on the surface of bioactive glasses is thought to be the principal reaction for bone–bioactive glass…”
Get full text

Syndecan-1 expression is upregulated in degenerating articular cartilage in a transgenic mouse model for osteoarthritis by Salminen-Mankonen, H., Säämänen, A. -. M., Jalkanen, M., Vuorio, E., Pirilä, L.

“…Objective: Mice heterozygous for the Del1 transgene locus with a short deletion mutation in the type II collagen gene develop early-onset degenerative changes…”
Get full text

Cyclic expression of mRNA transcripts for connective tissue components in the mouse ovary by Oksjoki, S., Sallinen, S., Vuorio, E., Anttila, L.

“…In the ovary, differentiation of germinal cells into primordial follicles, functional ovulatory follicles and corpus luteum, all take place in a connective…”
Get full text