Search Results - "Vuorela, Pia"

Flavones as Quorum Sensing Inhibitors Identified by a Newly Optimized Screening Platform Using Chromobacterium violaceum as Reporter Bacteria by Skogman, Malena E, Kanerva, Sonja, Manner, Suvi, Vuorela, Pia M, Fallarero, Adyary

“…Quorum sensing (QS) is the process by which bacteria produce and detect signal molecules to coordinate their collective behavior. This intercellular…”
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Towards fabrication of 3D printed medical devices to prevent biofilm formation by Sandler, Niklas, Salmela, Ida, Fallarero, Adyary, Rosling, Ari, Khajeheian, Mohammad, Kolakovic, Ruzica, Genina, Natalja, Nyman, Johan, Vuorela, Pia

“…The use of three-dimensional (3D) printing technologies is transforming the way that materials are turned into functional devices. We demonstrate in the…”
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Inhibitory activity of the isoflavone biochanin A on intracellular bacteria of genus Chlamydia and initial development of a buccal formulation by Hanski, Leena, Genina, Natalja, Uvell, Hanna, Malinovskaja, Kristina, Gylfe, Åsa, Laaksonen, Timo, Kolakovic, Ruzica, Mäkilä, Ermei, Salonen, Jarno, Hirvonen, Jouni, Elofsson, Mikael, Sandler, Niklas, Vuorela, Pia M

“…Given the established role of Chlamydia spp. as causative agents of both acute and chronic diseases, search for new antimicrobial agents against these…”
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Combining biofilm matrix measurements with biomass and viability assays in susceptibility assessments of antimicrobials against Staphylococcus aureus biofilms by Skogman, Malena Elise, Vuorela, Pia Maarit, Fallarero, Adyary

“…Despite that three types of assays (measuring biofilm viability, biomass, or matrix) are described to assess anti-biofilm activity, they are rarely used…”
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Systematic exploration of natural and synthetic flavonoids for the inhibition of Staphylococcus aureus biofilms by Manner, Suvi, Skogman, Malena, Goeres, Darla, Vuorela, Pia, Fallarero, Adyary

“…When single-cell (or suspended) bacteria switch into the biofilm lifestyle, they become less susceptible to antimicrobials, imposing the need for anti-biofilms…”
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Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages by HÄMÄLÄINEN, Mari, NIEMINEN, Riina, VUORELA, Pia, HEINONEN, Marina, MOILANEN, Eeva

“…In inflammation, bacterial products and proinflammatory cytokines induce the formation of large amounts of nitric oxide (NO) by inducible nitric oxide synthase…”
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Screening and Structural Analysis of Flavones Inhibiting Tankyrases by Narwal, Mohit, Haikarainen, Teemu, Fallarero, Adyary, Vuorela, Pia M, Lehtiö, Lari

“…Flavonoids are known for their beneficial effects on human health, and therefore the therapeutic potential of these compounds have been extensively studied…”
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The chemical and biological activities of quinones: overview and implications in analytical detection by El-Najjar, Nahed, Gali-Muhtasib, Hala, Ketola, Raimo A., Vuorela, Pia, Urtti, Arto, Vuorela, Heikki

“…Quinones are a class of natural and synthetic compounds that have several beneficial effects. Quinones are electron carriers playing a role in photosynthesis…”
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Effective Antibiofilm Polyketides against Staphylococcus aureus from the Pyranonaphthoquinone Biosynthetic Pathways of Streptomyces Species by Oja, Terhi, San Martin Galindo, Paola, Taguchi, Takaaki, Manner, Suvi, Vuorela, Pia M, Ichinose, Koji, Metsä-Ketelä, Mikko, Fallarero, Adyary

“…Streptomyces bacteria are renowned for their ability to produce bioactive secondary metabolites. Recently, synthetic biology has enabled the production of…”
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New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity by Manner, Suvi, Vahermo, Mikko, Skogman, Malena E., Krogerus, Sara, Vuorela, Pia M., Yli-Kauhaluoma, Jari, Fallarero, Adyary, Moreira, Vânia M.

“…The combination of the dehydroabietic acid scaffold with different amino acids resulted in the discovery of a new class of hybrid compounds that targets both…”
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Exploration of Microbial Communities Using the Thermo Scientific Varioskan LUX Multimode Reader and the Invitrogen EVOS FL Cell Imaging System by Anna Hiltunen, Malena Skogman, Pia M. Vuorela, Adyary Fallarero

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Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: The case of chelerythrine by Brunhofer, Gerda, Fallarero, Adyary, Karlsson, Daniela, Batista-Gonzalez, Ana, Shinde, Pravin, Gopi Mohan, C., Vuorela, Pia

“…The presented project started by screening a library consisting of natural and natural based compounds for their acetylcholinesterase (AChE) and…”
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Amphipathic β2,2-Amino Acid Derivatives Suppress Infectivity and Disrupt the Intracellular Replication Cycle of Chlamydia pneumoniae by Hanski, Leena, Ausbacher, Dominik, Tiirola, Terttu M, Strøm, Morten B, Vuorela, Pia M

“…We demonstrate in the current work that small cationic antimicrobial β2,2-amino acid derivatives (Mw < 500 Da) are highly potent against Chlamydia pneumoniae…”
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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries by Skogman, Malena E, Vuorela, Pia M, Fallarero, Adyary

“…Biofilms are regarded as one of the most challenging topics of modern biomedicine, and they are potentially responsible for over 80% of antibiotic-tolerant…”
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Exploration of Microbial Communities Using the Thermo Scientific Varioskan LUX Multimode Reader and the Invitrogen EVOS FL Cell Imaging System by Anna Hiltunen, Malena Skogman, Pia M. Vuorela, Adyary Fallarero

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Online Measurement of Real-Time Cytotoxic Responses Induced by Multi-Component Matrices, such as Natural Products, through Electric Cell-Substrate Impedance Sensing (ECIS) by Fallarero, Adyary, Batista-González, Ana E, Hiltunen, Anna K, Liimatainen, Jaana, Karonen, Maarit, Vuorela, Pia M

“…Natural products are complex matrices of compounds that are prone to interfere with the label-dependent methods that are typically used for cytotoxicity…”
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Dibenzocyclooctadiene lignans from Schisandra spp. selectively inhibit the growth of the intracellular bacteria Chlamydia pneumoniae and Chlamydia trachomatis by Hakala, Elina, Hanski, Leena, Uvell, Hanna, Yrjönen, Teijo, Vuorela, Heikki, Elofsson, Mikael, Vuorela, Pia Maarit

“…Lignans from Schisandra chinensis berries show various pharmacological activities, of which their antioxidative and cytoprotective properties are among the…”
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Automating a 96-well microtitre plate model for Staphylococcus aureus biofilms: an approach to screening of natural antimicrobial compounds by Sandberg, Malena, Määttänen, Anni, Peltonen, Jouko, Vuorela, Pia M, Fallarero, Adyary

“…Abstract The purpose of this study was to establish and automate an assay to be used for screening novel antimicrobial agents against biofilm-forming…”
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Recent advances in technologies for developing drugs against Chlamydia pneumoniae by Hanski, Leena, Vuorela, Pia M

“…The unique morphological characteristics, capacity of manipulating host cell function and association with chronic inflammatory diseases represent the features…”
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(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro by Fallarero, Adyary, Skogman, Malena, Kujala, Janni, Rajaratnam, Mohanathas, Moreira, Vânia M, Yli-Kauhaluoma, Jari, Vuorela, Pia

“…Potent drugs are desperately needed to counteract bacterial biofilm infections, especially those caused by gram-positive organisms, such as Staphylococcus…”
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