Search Results - "Vuong, Le T"

Phase-0/microdosing studies using PET, AMS, and LC-MS/MS: a range of study methodologies and conduct considerations. Accelerating development of novel pharmaceuticals through safe testing in humans - a practical guide by Burt, Tal, John, Christy S, Ruckle, Jon L, Vuong, Le T

“…Phase-0 studies, including microdosing, also called Exploratory Investigational New Drug (eIND) or exploratory clinical trials, are a regulatory framework for…”
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Use of accelerator mass spectrometry to measure the pharmacokinetics and peripheral blood mononuclear cell concentrations of zidovudine by Vuong, Le T, Ruckle, Jon L, Blood, Arlin B, Reid, Michael J, Wasnich, Richard D, Synal, Hans-Arno, Dueker, Stephen R

“…The remarkable sensitivity of accelerator mass spectrometry (AMS) is finding many new applications in pharmacology. In this study AMS was used to measure…”
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Early human ADME using microdoses and microtracers: bioanalytical considerations by Dueker, Stephen R, Lohstroh, Peter N, Giacomo, Jason A, Le, T Vuong, Keck, Bradly D, Vogel, John S

“…Quantitative assessment of metabolites of drug candidates in early-phase clinical development presents an analytical challenge when methods, standards and…”
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Pharmacokinetic analysis of 14C-ursodiol in newborn infants using accelerator mass spectrometry by Gordi, Toufigh, Baillie, Rebecca, Vuong, Le T., Abidi, Saira, Dueker, Stephen, Vasquez, Herbert, Pegis, Priscilla, Hopper, Andrew O., Power, Gordon G., Blood, Arlin B.

“…Pharmacokinetic studies in the neonatal population are often limited by the small volume of blood that can be collected. The high sensitivity of…”
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Quantifying exploratory low dose compounds in humans with AMS by Dueker, Stephen R., Vuong, Le T., Lohstroh, Peter N., Giacomo, Jason A., Vogel, John S.

“…Accelerator Mass Spectrometry is an established technology whose essentiality extends beyond simply a better detector for radiolabeled molecules. Attomole…”
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Phytochemical research using accelerator mass spectrometry by Vuong, L.T, Buchholz, B.A, Lame, M.W, Dueker, S.R

“…Vegetables and fruits provide an array of microchemicals in the form of vitamins and secondary metabolites (phytochemicals) that may lower the risk of chronic…”
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Plasma β-carotene and retinol concentrations of children increase after a 30-d supplementation with the fruit Momordica cochinchinensis (gac) by Vuong, Le T, Dueker, Stephen R, Murphy, Suzanne P

“…Background: In rural Vietnam, vitamin A deficiency is a concern. Among the indigenous fruit and vegetables, Momordica cochinchinensis (gac) fruit has been…”
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Pharmacokinetic analysis of 14 C‐ursodiol in newborn infants using accelerator mass spectrometry by Gordi, Toufigh, Baillie, Rebecca, Vuong, Le T., Abidi, Saira, Dueker, Stephen, Vasquez, Herbert, Pegis, Priscilla, Hopper, Andrew O., Power, Gordon G., Blood, Arlin B.

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Quantifying exploratory low dose compounds in humans with AMS: NEW STRATEGY FOR DRUG DEVELOPMENT WITH EXPLORATORY IND STUDIES: SCIENTIFIC BASIS AND FUTURE DIRECTIONS by DUEKER, Stephen R, VUONG, Le T, LOHSTROH, Peter N, GIACOMO, Jason A, VOGEL, John S

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Underutilized β-Carotene–Rich Crops of Vietnam by Vuong, Le T.

“…Solutions to micronutrient deficiencies that capitalize upon indigenous resources and foodstuffs offer a long-term mechanism for elevating the health status of…”
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Plasma beta-carotene and retinol concentrations of children increase after a 30-d supplementation with the fruit Momordica cochinchiensis (gac) by Vuong, Le T, Dueker, Stephen R, Murphy, Suzanne P

“…Among Vietnam's indigenous fruit and vegetables, Momordica cochinchinensis (gac) fruit has been identified as having the highest beta-carotene concentration,…”
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Plasma β-carotene and retinol concentrations of children increase after a 30-d supplementation with the fruit Momordica cochinchinensis (gac)123 by Vuong, Le T, Dueker, Stephen R, Murphy, Suzanne P

“…In rural Vietnam, vitamin A deficiency is a concern. Among the indigenous fruit and vegetables, Momordica cochinchinensis (gac) fruit has been identified as…”
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