Search Results - "Vukusic, Kruno"
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Anaphase B: Long-standing models meet new concepts
Published in Seminars in cell & developmental biology (01-09-2021)“…Mitotic cell divisions ensure stable transmission of genetic information from a mother to daughter cells in a series of generations. To ensure this crucial…”
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Force-generating mechanisms of anaphase in human cells
Published in Journal of cell science (16-09-2019)“…What forces drive chromosome segregation remains one of the most challenging questions in cell division. Even though the duration of anaphase is short, it is…”
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Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation
Published in Developmental cell (03-05-2021)“…Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins…”
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Microtubule Sliding within the Bridging Fiber Pushes Kinetochore Fibers Apart to Segregate Chromosomes
Published in Developmental cell (09-10-2017)“…During cell division, mitotic spindle microtubules segregate chromosomes by exerting forces on kinetochores. What forces drive chromosome segregation in…”
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Nuclear chromosome locations dictate segregation error frequencies
Published in Nature (London) (21-07-2022)“…Chromosome segregation errors during cell divisions generate aneuploidies and micronuclei, which can undergo extensive chromosomal rearrangements such as…”
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Vertebrate centromeres in mitosis are functionally bipartite structures stabilized by cohesin
Published in Cell (06-06-2024)“…Centromeres are scaffolds for the assembly of kinetochores that ensure chromosome segregation during cell division. How vertebrate centromeres obtain a…”
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Expansion microscopy of the mitotic spindle
Published in Expansion Microscopy for Cell Biology (2021)“…The mitotic spindle is a dynamic and complex cellular structure made of microtubules and associated proteins. Although the general localization of most…”
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Recombinant therapeutic proteins produced in plants: towards engineering of human-type O-and N-glycosylation
Published in Periodicum biologorum (30-06-2016)“…Background and Purpose: Recombinant DNA technology has allowed expression of different heterologous proteins in many host systems, ranging from prokaryotic to…”
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Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores
Published in Nature communications (05-01-2016)“…During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore…”
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Plasmodium ARK2 and EB1 drive unconventional spindle dynamics, during chromosome segregation in sexual transmission stages
Published in Nature communications (13-09-2023)“…The Aurora family of kinases orchestrates chromosome segregation and cytokinesis during cell division, with precise spatiotemporal regulation of its catalytic…”
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Polar Chromosomes-Challenges of a Risky Path
Published in Cells (Basel, Switzerland) (03-05-2022)“…The process of chromosome congression and alignment is at the core of mitotic fidelity. In this review, we discuss distinct spatial routes that the chromosomes…”
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New characterization and safety evaluation of human limbal stem cells used in clinical application: fidelity of mitotic process and mitotic spindle morphologies
Published in Stem cell research & therapy (13-12-2023)“…Limbal stem cells (LSCs) are crucial for the regeneration of the corneal epithelium in patients with limbal stem cell deficiency (LSCD). Thus, LSCs during…”
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Torques and Forces in the Mitotic Spindle
Published in Biophysical journal (02-02-2018)Get full text
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Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy
Published in Proceedings of the National Academy of Sciences - PNAS (05-11-2024)“…The female reproductive lifespan is highly dependent on egg quality, especially the presence of a normal number of chromosomes in an egg, known as euploidy…”
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