Search Results - "Vujicic‐Zagar, Andreja"
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Structural and time‐resolved mechanistic investigations of protein hydrolysis by the acidic proline‐specific endoprotease from Aspergillus niger
Published in Protein science (01-01-2024)“…Proline‐specific endoproteases have been successfully used in, for example, the in‐situ degradation of gluten, the hydrolysis of bitter peptides, the reduction…”
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Functional Diversity of Tandem Substrate-Binding Domains in ABC Transporters from Pathogenic Bacteria
Published in Structure (London) (08-10-2013)“…The ATP-binding cassette (ABC) transporter GlnPQ is an essential uptake system for amino acids in gram-positive pathogens and related nonpathogenic bacteria…”
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3
Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module
Published in Molecular cell (19-07-2018)“…Class II phosphoinositide 3-kinases (PI3K-C2) are large multidomain enzymes that control cellular functions ranging from membrane dynamics to cell signaling…”
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Structural basis for arabinoxylo‐oligosaccharide capture by the probiotic Bifidobacterium animalis subsp. lactis Bl‐04
Published in Molecular microbiology (01-12-2013)“…Summary Glycan utilization plays a key role in modulating the composition of the gut microbiota, but molecular insight into oligosaccharide uptake by this…”
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5
Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes
Published in Proceedings of the National Academy of Sciences - PNAS (14-12-2010)“…Glucansucrases are large enzymes belonging to glycoside hydrolase family 70, which catalyze the cleavage of sucrose into fructose and glucose, with the…”
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Flexibility of truncated and full‐length glucansucrase GTF180 enzymes from Lactobacillus reuteri 180
Published in The FEBS journal (01-05-2014)“…Glucansucrase enzymes synthesize high‐molecular‐mass extracellular α‐glucan polysaccharides from sucrose. Previously, the crystal structure of truncated…”
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A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch
Published in Developmental cell (20-11-2017)“…Clathrin-mediated endocytosis occurs by bending and remodeling of the membrane underneath the coat. Bin-amphiphysin-rvs (BAR) domain proteins are crucial for…”
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The structural basis of modularity in ECF-type ABC transporters
Published in Nature structural & molecular biology (01-07-2011)“…Energy coupling factor (ECF) transporters consist of an integral membrane protein that confers substrate specificity (S-component) and an energizing module…”
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Crystal Structure of the IrrE Protein, a Central Regulator of DNA Damage Repair in Deinococcaceae
Published in Journal of molecular biology (27-02-2009)“…Deinococcaceae are famous for their extreme radioresistance. Transcriptome analysis in Deinococcus radiodurans revealed a group of genes up-regulated in…”
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Structure of the α-1,6/α-1,4-specific glucansucrase GTFA from Lactobacillus reuteri 121
Published in Acta crystallographica. Section F, Structural biology and crystallization communications (01-12-2012)“…The reuteransucrase GTFA from Lactobacillus reuteri 121, which belongs to glycosyl hydrolase family GH70, synthesizes branched α‐glucans with both α‐1,6‐ and…”
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Complex oligomeric structure of a truncated form of DdrA: A protein required for the extreme radiotolerance of Deinococcus
Published in Biochimica et biophysica acta (01-07-2008)“…In order to preserve their genome integrity, organisms have developed elaborate tactics for genome protection and repair. The Deinococcus radiodurans bacteria…”
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Structural basis of phosphatidylinositol 3-kinase C2α function
Published in Nature structural & molecular biology (01-03-2022)“…Phosphatidylinositol 3-kinase type 2α (PI3KC2α) is an essential member of the structurally unresolved class II PI3K family with crucial functions in lipid…”
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An ATP Binding Cassette Transporter Mediates the Uptake of α-(1,6)-Linked Dietary Oligosaccharides in Bifidobacterium and Correlates with Competitive Growth on These Substrates
Published in The Journal of biological chemistry (16-09-2016)“…The molecular details and impact of oligosaccharide uptake by distinct human gut microbiota (HGM) are currently not well understood. Non-digestible dietary…”
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Structural basis for arabinoxylo-oligosaccharide capture by the probiotic Bifidobacterium animalis subsp. lactisBl-04
Published in Molecular microbiology (01-12-2013)“…Glycan utilization plays a key role in modulating the composition of the gut microbiota, but molecular insight into oligosaccharide uptake by this microbial…”
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Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
Published in Intensive care medicine (01-08-2022)“…Purpose The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to…”
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Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
Published in Critical care (London, England) (2022)“…Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial…”
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Towards understanding phosphoinositide 3-kinase γ (PI3Kγ)-dependent signaling network
Published in Acta crystallographica. Section A, Foundations and advances (23-08-2015)“…Abstract only…”
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The predictive value of highly malignant EEG patterns after cardiac arrest: evaluation of the ERC-ESICM recommendations
Published in Intensive care medicine (2024)“…Purpose The 2021 guidelines endorsed by the European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) recommend using…”
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Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial
Published in Critical care (London, England) (01-12-2022)“…Abstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the…”
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Structural basis for arabinoxylo‐oligosaccharide capture by the probiotic B ifidobacterium animalis subsp. lactis Bl ‐04
Published in Molecular microbiology (01-12-2013)“…Summary Glycan utilization plays a key role in modulating the composition of the gut microbiota, but molecular insight into oligosaccharide uptake by this…”
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