Search Results - "Vujanovic, Nikola L."

Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands by Munich, Stephan, Sobo-Vujanovic, Andrea, Buchser, William J., Beer-Stolz, Donna, Vujanovic, Nikola L.

“…Autocrine and paracrine cell communication can be conveyed by multiple mediators, including membrane-associate proteins, secreted proteins and exosomes…”
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Human B Cells Mediate Innate Anti-Cancer Cytotoxicity Through Concurrent Engagement of Multiple TNF Superfamily Ligands by Janjic, Bratislav M, Kulkarni, Aditi, Ferris, Robert L, Vujanovic, Lazar, Vujanovic, Nikola L

“…The essential innate immunity effector cells, natural killer and dendritic cells, express multiple plasma membrane-associated tumor necrosis factor (TNF)…”
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Inhibition of Soluble Tumor Necrosis Factor Prevents Chemically Induced Carcinogenesis in Mice by Sobo-Vujanovic, Andrea, Vujanovic, Lazar, DeLeo, Albert B, Concha-Benavente, Fernando, Ferris, Robert L, Lin, Yan, Vujanovic, Nikola L

“…TNF is a potent promoter of carcinogenesis and potentially important target for cancer prevention. TNF is produced as functionally distinct transmembrane and…”
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Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell–natural killer cell crosstalk by Xu, Jun, Chakrabarti, Ayan K., Tan, Jennifer L., Ge, Lisheng, Gambotto, Andrea, Vujanovic, Nikola L.

“…Dendritic cells (DCs) and natural killer (NK) cells are essential components of the innate immune system and have a central role in initiation and regulation…”
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Adenovirus-engineered human dendritic cells induce natural killer cell chemotaxis via CXCL8/IL-8 and CXCL10/IP-10 by Vujanovic, Lazar, Ballard, Wenners, Thorne, Stephen H., Vujanovic, Nikola L., Butterfield, Lisa H.

“…Recombinant adenovirus-engineered dendritic cells (Ad.DC) are potent vaccines for induction of anti-viral and anti-cancer T cell immunity. The effectiveness of…”
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Constitutive Expression and Role of the TNF Family Ligands in Apoptotic Killing of Tumor Cells by Human NK Cells by Kashii, Yoshiro, Giorda, Roberto, Herberman, Ronald B, Whiteside, Theresa L, Vujanovic, Nikola L

“…Natural killer cells mediate spontaneously secretory/necrotic killing against rare leukemia cell lines and a nonsecretory/apoptotic killing against a large…”
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Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells by Sobo-Vujanovic, Andrea, Munich, Stephan, Vujanovic, Nikola L.

“…•We found that dendritic cell exosomes (DCex) bound bacterial TLR ligands.•DCex-TLR-ligand complexes strongly activated bystander DCs.•The activated DCs highly…”
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Soluble TNF Regulates TACE via AP-2α Transcription Factor in Mouse Dendritic Cells by Ge, Lisheng, Vujanovic, Nikola L

“…Dendritic cells (DCs), the essential immunoregulatory and APCs, are major producers of the central mediator of inflammation, soluble TNF-α (sTNF). sTNF is…”
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Role of TNF superfamily ligands in innate immunity by Vujanovic, Nikola L.

“…Natural killer (NK) cells and dendritic cells (DCs) are essential effector cells of the innate immune system that rapidly recognize and eliminate microbial…”
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Sheddase Activity of Tumor Necrosis Factor-α Converting Enzyme Is Increased and Prognostically Valuable in Head and Neck Cancer by Ge, Lisheng, Baskic, Dejan, Basse, Per, Vujanovic, Lazar, Unlu, Sebnem, Yoneyama, Toshie, Vujanovic, Andrea, Han, Jie, Bankovic, Dragic, Szczepanski, Miroslaw J, Hunt, Jennifer L, Herberman, Ronald B, Gollin, Susanne M, Ferris, Robert L, Whiteside, Theresa L, Myers, Eugene N, Vujanovic, Nikola L

“…Tumor necrosis factor α converting enzyme (TACE) is a sheddase overexpressed in cancers that generates cancer cell growth and survival factors, and is…”
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Virally infected and matured human dendritic cells activate natural killer cells via cooperative activity of plasma membrane-bound TNF and IL-15 by Vujanovic, Lazar, Szymkowski, David E., Alber, Sean, Watkins, Simon C., Vujanovic, Nikola L., Butterfield, Lisa H.

“…Recombinant adenovirus-engineered dendritic cells (Ad.DCs) are potent immunologic adjuvants of antiviral and anticancer vaccines. The effectiveness of…”
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Dendritic cells and natural killer cells interact via multiple TNF family molecules by Makarenkova, Valeria, Chakrabarti, Ayan K., Liberatore, Jennifer A., Popovic, Petar, Lu, Ganwei, Watkins, Simon, Vujanovic, Nikola L.

“…Dendritic cells (DC) and natural killer (NK) cells are essential components of the innate immune system, which rapidly sense and eliminate invading pathogens…”
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Development of flow cytometry assays for measuring cell-membrane enzyme activity on individual cells by Gorry, Michael, Yoneyama, Toshie, Vujanovic, Lazar, Moss, Marcia L, Garlin, Michelle A, Miller, Miles A, Herman, James, Stabile, Laura P, Vujanovic, Nikola L

“…Cell-membrane expressing enzymes such as ADAM (a disintegrin and metalloproteinase) superfamily members are thought to be key catalysts of vital cellular…”
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ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker by Yoneyama, Toshie, Gorry, Michael, Sobo-Vujanovic, Andrea, Lin, Yan, Vujanovic, Lazar, Gaither-Davis, Autumn, Moss, Marcia L, Miller, Miles A, Griffith, Linda G, Lauffenburger, Douglas A, Stabile, Laura P, Herman, James, Vujanovic, Nikola L

“…: Increases in expression of ADAM10 and ADAM17 genes and proteins are inconsistently found in cancer lesions, and are not validated as clinically useful…”
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Suppression of natural killer-cell and dendritic-cell apoptotic tumoricidal activity in patients with head and neck cancer by Baskic, Dejan, Vujanovic, Lazar, Arsenijevic, Nebojsa, Whiteside, Theresa L., Myers, Eugene N., Vujanovic, Nikola L.

“…Background Natural killer (NK) cells and dendritic cells (DCs) mediate tumor cell apoptosis using tumor necrosis factor superfamily ligands (TNFSFLs). This…”
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Acupuncture May Stimulate Anticancer Immunity via Activation of Natural Killer Cells by Johnston, Michael Francis, Ortiz Sánchez, Elizabeth, Vujanovic, Nikola L., Li, Wenhui

“…This article presents the hypothesis that acupuncture enhances anticancer immune functions by stimulating natural killer (NK) cells. It provides background…”
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The Endothelial Cell-Produced Antiangiogenic Cytokine Vascular Endothelial Growth Inhibitor Induces Dendritic Cell Maturation by Tian, Fang, Grimaldo, Sammy, Fugita, Mitsugu, Cutts, Jonita, Vujanovic, Nikola L, Li, Lu-Yuan

“…Angiogenesis is an essential component of chronic inflammation that is linked to carcinogenesis. In this study, we report that human vascular endothelial…”
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A novel epitope of N-CAM defines precursors of human adherent NK cells by Li, Shen, Xu, Jun, Makarenkova, Valeria P., Tjandrawan, Tjendimin, Vakkila, Jukka, Reichert, Torsten, Gooding, William, Lagenaur, Carl F., Achim, Cristian L., Chambers, William H., Herberman, Ronald B., Whiteside, Theresa L., Vujanovic, Nikola L.

“…Activated, adherent natural killer (A‐NK) cells represent a distinct subpopulation of interleukin (IL)‐2‐stimulated NK cells, which are selectively endowed…”
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Innate Direct Anticancer Effector Function of Human Immature Dendritic Cells. II. Role of TNF, Lymphotoxin-α1β2, Fas Ligand, and TNF-Related Apoptosis-Inducing Ligand by Lu, Ganwei, Janjic, Bratislav M., Janjic, Jelena, Whiteside, Theresa L., Storkus, Walter J., Vujanovic, Nikola L.

“…Our recent studies have demonstrated that human immature dendritic cells (DCs) are able to directly and effectively mediate apoptotic killing against a wide…”
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Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity by TATSUMI, Tomohide, JIAN HUANG, GOODING, William E, GAMBOTTO, Andrea, ROBBINS, Paul D, VUJANOVIC, Nikola L, ALBER, Sean M, WATKINS, Simon C, OKADA, Hideho, STORKUS, Walter J

“…Dendritic cells (DCs) were adenovirally engineered to constitutively and durably secrete the potent Th1-biasing cytokines interleukin (IL)-12 (AdIL12DC) and/or…”
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