Search Results - "Vugts, J"

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer by Niemeijer, A. N., Leung, D., Huisman, M. C., Bahce, I., Hoekstra, O. S., van Dongen, G. A. M. S., Boellaard, R., Du, S., Hayes, W., Smith, R., Windhorst, A. D., Hendrikse, N. H., Poot, A., Vugts, D. J., Thunnissen, E., Morin, P., Lipovsek, D., Donnelly, D. J., Bonacorsi, S. J., Velasquez, L. M., de Gruijl, T. D., Smit, E. F., de Langen, A. J.

“…PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might…”
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Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101) by Gaillard, Pieter J, Appeldoorn, Chantal C M, Dorland, Rick, van Kregten, Joan, Manca, Francesca, Vugts, Danielle J, Windhorst, Bert, van Dongen, Guus A M S, de Vries, Helga E, Maussang, David, van Tellingen, Olaf

“…Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chemotherapeutics is limited due to the presence of the…”
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Towards PET imaging of the dynamic phenotypes of microglia by Beaino, Wissam, Janssen, Bieneke, Vugts, Danielle J., Vries, Helga E., Windhorst, Albert D.

“…There is increasing evidence showing the heterogeneity of microglia activation in neuroinflammatory and neurodegenerative diseases. It has been hypothesized…”
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PET Imaging of Microglial Activation-Beyond Targeting TSPO by Janssen, Bieneke, Vugts, Danielle J, Windhorst, Albert D, Mach, Robert H

“…Neuroinflammation, which involves microglial activation, is thought to play a key role in the development and progression of neurodegenerative diseases and…”
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The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study by Hagens, Marloes H. J., Golla, Sandeep S. V., Janssen, Bieneke, Vugts, Danielle J., Beaino, Wissam, Windhorst, Albert D., O’Brien-Brown, James, Kassiou, Michael, Schuit, Robert C., Schwarte, Lothar A., de Vries, Helga E., Killestein, Joep, Barkhof, Frederik, van Berckel, Bart N. M., Lammertsma, Adriaan A.

“…Purpose The novel PET tracer [ 11 C]SMW139 binds with high affinity to the P2X 7 receptor, which is expressed on pro-inflammatory microglia. The purposes of…”
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Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography by Janssen, Bieneke, Vugts, Danielle J., Funke, Uta, Molenaar, Ger T., Kruijer, Perry S., van Berckel, Bart N.M., Lammertsma, Adriaan A., Windhorst, Albert D.

“…Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain, including Alzheimer's disease, multiple sclerosis and stroke…”
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Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice by Alsaid, Hasan, Skedzielewski, Tinamarie, Rambo, Mary V, Hunsinger, Kristen, Hoang, Bao, Fieles, William, Long, Edward R, Tunstead, James, Vugts, Danielle J, Cleveland, Matthew, Clarke, Neil, Matheny, Christopher, Jucker, Beat M

“…The purpose of this work was to use various molecular imaging techniques to non-invasively assess GSK2849330 (anti HER3 ADCC and CDC enhanced 'AccretaMab'…”
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[89Zr]-immuno-PET prediction of response to rituximab treatment in patients with therapy refractory interstitial pneumonitis: a phase 2 trial by Adams, H., van de Garde, E. M. W., Vugts, D. J., Grutters, J. C., Oyen, Wim. J.G., Keijsers, R. G.

“…Introduction Immune-mediated interstitial pneumonitis may be treated with anti-CD20 therapy after failure of conventional therapies. However, clinical response…”
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State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis by Haveman, Lizeth Y. F., Vugts, Danielle J., Windhorst, Albert D.

“…Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and…”
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Whole-Body HER2 Heterogeneity Identified on HER2 PET in HER2-Negative, -Low, and -Positive Metastatic Breast Cancer by Eisses, Bertha, van Geel, Jasper J L, Brouwers, Adrienne H, Bensch, Frederike, Elias, Sjoerd G, Kuip, Evelien J M, Jager, Agnes, van der Vegt, Bert, Lub-de Hooge, Marjolijn N, Emmering, Jasper, Arens, Anne I J, Zwezerijnen, Gerben J C, Vugts, Daniëlle J, Menke-van der Houven van Oordt, C Willemien, de Vries, Elisabeth G E, Schröder, Carolina P

“…Understanding which patients with human epidermal growth factor receptor 2 (HER2)-negative or -low metastatic breast cancer (MBC) benefit from HER2-targeted…”
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PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139 by Beaino, Wissam, Janssen, Bieneke, Kooijman, Esther, Vos, Ricardo, Schuit, Robert C, O'Brien-Brown, James, Kassiou, Michael, van het Hof, Bert, Vugts, Danielle J, de Vries, Helga E, Windhorst, Albert D

“…Abstract Background Non-invasive imaging of the activation status of microglia and the ability to identify a pro- or anti-inflammatory environment can provide…”
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Improving Routine 89Zr‐Immuno‐PET Applications: Mild Iron Removal Can Favor the Use of Fe‐DFO‐N‐suc‐TFP Ester Over p‐NCS‐Bz‐DFO by Wuensche, Thomas E., Nauta, Sabine, Dongen, Guus A. M. S., Vugts, Danielle J.

“…ABSTRACT A key aspect for the applicability of 89Zr‐radioimmunoconjugates is inert modification and radiolabeling. The two commercially available bifunctional…”
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Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state by Villa, Alessandro, Klein, Barbara, Janssen, Bieneke, Pedragosa, Jordi, Pepe, Giovanna, Zinnhardt, Bastian, Vugts, Danielle J, Gelosa, Paolo, Sironi, Luigi, Beaino, Wissam, Damont, Annelaure, Dollé, Frédéric, Jego, Benoit, Winkeler, Alexandra, Ory, Dieter, Solin, Olof, Vercouillie, Johnny, Funke, Uta, Laner-Plamberger, Sandra, Blomster, Linda V, Christophersen, Palle, Vegeto, Elisabetta, Aigner, Ludwig, Jacobs, Andreas, Planas, Anna M, Maggi, Adriana, Windhorst, Albert D

“…Microglia are potential targets for therapeutic intervention in neurological and neurodegenerative diseases affecting the central nervous system. In order to…”
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Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study by Wechalekar, Ashutosh, Antoni, Gunnar, Al Azzam, Wasfi, Bergström, Mats, Biswas, Swethajit, Chen, Chao, Cheriyan, Joseph, Cleveland, Matthew, Cookson, Louise, Galette, Paul, Janiczek, Robert L, Kwong, Raymond Y, Lukas, Mary Ann, Millns, Helen, Richards, Duncan, Schneider, Ian, Solomon, Scott D, Sörensen, Jens, Storey, James, Thompson, Douglas, van Dongen, Guus, Vugts, Danielle J, Wall, Anders, Wikström, Gerhard, Falk, Rodney H

“…In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of…”
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The Development of Positron Emission Tomography Tracers for In Vivo Targeting the Kinase Domain of the Epidermal Growth Factor Receptor by Högnäsbacka, Antonia, Poot, Alex J, Vugts, Danielle J, van Dongen, Guus A M S, Windhorst, Albert D

“…Multiple small molecule PET tracers have been developed for the imaging of the epidermal growth factor receptor (EGFR). These tracers target the tyrosine…”
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Non-specific irreversible 89Zr-mAb uptake in tumours: evidence from biopsy-proven target-negative tumours using 89Zr-immuno-PET by Wijngaarden, Jessica E., Jauw, Yvonne W. S., Zwezerijnen, Gerben J. C., de Wit-van der Veen, Berlinda J., Vugts, Daniëlle J., Zijlstra, Josée M., van Dongen, Guus A. M. S., Boellaard, Ronald, Menke-van der Houven van Oordt, C. Willemien, Huisman, Marc C.

“…Background Distribution of mAbs into tumour tissue may occur via different processes contributing differently to the 89 Zr-mAb uptake on PET. Target-specific…”
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Eligibility for Liver Transplantation in Patients with Perihilar Cholangiocarcinoma by Vugts, Jaynee J. A., Gaspersz, Marcia P., Roos, Eva, Franken, Lotte C., Olthof, Pim B., Coelen, Robert J. S., van Vugt, Jeroen L. A., Labeur, Tim A., Brouwer, Lieke, Besselink, Marc G. H., IJzermans, Jan N. M., Darwish Murad, Sarwa, van Gulik, Thomas M., de Jonge, Jeroen, Polak, Wojciech G., Busch, Olivier R. C., Erdmann, Joris L., Groot Koerkamp, Bas, Buettner, Stefan

“…Background Liver transplantation (LT) has been performed in a select group of patients presenting with unresectable or primary sclerosing cholangitis…”
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In memoriam: Marion Hendriks-de Jong by Krenning, Eric P., Krestin, Gabriel P., Bernsen, Monique R., Dalm, Simone U., Boerman, Otto C., Elsinga, Philip H., Glaudemans, Andor W. J. M., Vugts, Daniëlle J., Kunikowska, Jolanta, Erba, Paola A., Evangelista, Laura, Nock, Berthold A., Maina, Theodosia

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F8-IL10: A New Potential Antirheumatic Drug Evaluated by a PET-Guided Translational Approach by Bruijnen, Stefan T.G, Chandrupatla, Durga M.S.H, Giovanonni, Leonardo, Neri, Dario, Vugts, Danielle J, Huisman, Marc C, Hoekstra, Otto S, Musters, René J.P, Lammertsma, Adriaan A, van Dongen, Guus A.M.S, Jansen, Gerrit, Molthoff, Carla F.M, van der Laken, Conny J

“…Antibody fragment F8-mediated interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin…”
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Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers by van der Born, Dion, Herscheid, J Koos D M, Orru, Romano V A, Vugts, Danielle J

“…A new strategy towards [(18)F]trifluoromethyl-containing compounds is developed. [(18)F]trifluoromethane is synthesised in a fast and efficient manner and…”
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