Search Results - "Vugts, Danielle J."

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101) by Gaillard, Pieter J, Appeldoorn, Chantal C M, Dorland, Rick, van Kregten, Joan, Manca, Francesca, Vugts, Danielle J, Windhorst, Bert, van Dongen, Guus A M S, de Vries, Helga E, Maussang, David, van Tellingen, Olaf

“…Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chemotherapeutics is limited due to the presence of the…”
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Towards PET imaging of the dynamic phenotypes of microglia by Beaino, Wissam, Janssen, Bieneke, Vugts, Danielle J., Vries, Helga E., Windhorst, Albert D.

“…There is increasing evidence showing the heterogeneity of microglia activation in neuroinflammatory and neurodegenerative diseases. It has been hypothesized…”
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PET Imaging of Microglial Activation-Beyond Targeting TSPO by Janssen, Bieneke, Vugts, Danielle J, Windhorst, Albert D, Mach, Robert H

“…Neuroinflammation, which involves microglial activation, is thought to play a key role in the development and progression of neurodegenerative diseases and…”
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The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study by Hagens, Marloes H. J., Golla, Sandeep S. V., Janssen, Bieneke, Vugts, Danielle J., Beaino, Wissam, Windhorst, Albert D., O’Brien-Brown, James, Kassiou, Michael, Schuit, Robert C., Schwarte, Lothar A., de Vries, Helga E., Killestein, Joep, Barkhof, Frederik, van Berckel, Bart N. M., Lammertsma, Adriaan A.

“…Purpose The novel PET tracer [ 11 C]SMW139 binds with high affinity to the P2X 7 receptor, which is expressed on pro-inflammatory microglia. The purposes of…”
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Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography by Janssen, Bieneke, Vugts, Danielle J., Funke, Uta, Molenaar, Ger T., Kruijer, Perry S., van Berckel, Bart N.M., Lammertsma, Adriaan A., Windhorst, Albert D.

“…Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain, including Alzheimer's disease, multiple sclerosis and stroke…”
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Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice by Alsaid, Hasan, Skedzielewski, Tinamarie, Rambo, Mary V, Hunsinger, Kristen, Hoang, Bao, Fieles, William, Long, Edward R, Tunstead, James, Vugts, Danielle J, Cleveland, Matthew, Clarke, Neil, Matheny, Christopher, Jucker, Beat M

“…The purpose of this work was to use various molecular imaging techniques to non-invasively assess GSK2849330 (anti HER3 ADCC and CDC enhanced 'AccretaMab'…”
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Improving Routine 89Zr‐Immuno‐PET Applications: Mild Iron Removal Can Favor the Use of Fe‐DFO‐N‐suc‐TFP Ester Over p‐NCS‐Bz‐DFO by Wuensche, Thomas E., Nauta, Sabine, Dongen, Guus A. M. S., Vugts, Danielle J.

“…ABSTRACT A key aspect for the applicability of 89Zr‐radioimmunoconjugates is inert modification and radiolabeling. The two commercially available bifunctional…”
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State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis by Haveman, Lizeth Y. F., Vugts, Danielle J., Windhorst, Albert D.

“…Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and…”
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PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139 by Beaino, Wissam, Janssen, Bieneke, Kooijman, Esther, Vos, Ricardo, Schuit, Robert C, O'Brien-Brown, James, Kassiou, Michael, van het Hof, Bert, Vugts, Danielle J, de Vries, Helga E, Windhorst, Albert D

“…Abstract Background Non-invasive imaging of the activation status of microglia and the ability to identify a pro- or anti-inflammatory environment can provide…”
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Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state by Villa, Alessandro, Klein, Barbara, Janssen, Bieneke, Pedragosa, Jordi, Pepe, Giovanna, Zinnhardt, Bastian, Vugts, Danielle J, Gelosa, Paolo, Sironi, Luigi, Beaino, Wissam, Damont, Annelaure, Dollé, Frédéric, Jego, Benoit, Winkeler, Alexandra, Ory, Dieter, Solin, Olof, Vercouillie, Johnny, Funke, Uta, Laner-Plamberger, Sandra, Blomster, Linda V, Christophersen, Palle, Vegeto, Elisabetta, Aigner, Ludwig, Jacobs, Andreas, Planas, Anna M, Maggi, Adriana, Windhorst, Albert D

“…Microglia are potential targets for therapeutic intervention in neurological and neurodegenerative diseases affecting the central nervous system. In order to…”
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Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study by Wechalekar, Ashutosh, Antoni, Gunnar, Al Azzam, Wasfi, Bergström, Mats, Biswas, Swethajit, Chen, Chao, Cheriyan, Joseph, Cleveland, Matthew, Cookson, Louise, Galette, Paul, Janiczek, Robert L, Kwong, Raymond Y, Lukas, Mary Ann, Millns, Helen, Richards, Duncan, Schneider, Ian, Solomon, Scott D, Sörensen, Jens, Storey, James, Thompson, Douglas, van Dongen, Guus, Vugts, Danielle J, Wall, Anders, Wikström, Gerhard, Falk, Rodney H

“…In a Phase I study treatment with the serum amyloid P component (SAP) depleter miridesap followed by monoclonal antibody to SAP (dezamizumab) showed removal of…”
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The Development of Positron Emission Tomography Tracers for In Vivo Targeting the Kinase Domain of the Epidermal Growth Factor Receptor by Högnäsbacka, Antonia, Poot, Alex J, Vugts, Danielle J, van Dongen, Guus A M S, Windhorst, Albert D

“…Multiple small molecule PET tracers have been developed for the imaging of the epidermal growth factor receptor (EGFR). These tracers target the tyrosine…”
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F8-IL10: A New Potential Antirheumatic Drug Evaluated by a PET-Guided Translational Approach by Bruijnen, Stefan T.G, Chandrupatla, Durga M.S.H, Giovanonni, Leonardo, Neri, Dario, Vugts, Danielle J, Huisman, Marc C, Hoekstra, Otto S, Musters, René J.P, Lammertsma, Adriaan A, van Dongen, Guus A.M.S, Jansen, Gerrit, Molthoff, Carla F.M, van der Laken, Conny J

“…Antibody fragment F8-mediated interleukin 10 (IL10) delivery is a novel treatment for rheumatoid arthritis (RA). F8 binds to the extra-domain-A of fibronectin…”
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Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers by van der Born, Dion, Herscheid, J Koos D M, Orru, Romano V A, Vugts, Danielle J

“…A new strategy towards [(18)F]trifluoromethyl-containing compounds is developed. [(18)F]trifluoromethane is synthesised in a fast and efficient manner and…”
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Phase 0 microdosing PET study using the human mini antibody F16SIP in head and neck cancer patients by Heuveling, Derrek A, de Bree, Remco, Vugts, Danielle J, Huisman, Marc C, Giovannoni, Leonardo, Hoekstra, Otto S, Leemans, C René, Neri, Dario, van Dongen, Guus A M S

“…The aim of this microdosing phase 0 clinical study was to obtain initial information about pharmacokinetics, biodistribution, and specific tumor targeting of…”
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Immuno-PET Imaging of Atherosclerotic Plaques with [ 89 Zr]Zr-Anti-CD40 mAb-Proof of Concept by Poels, Kikkie, Schreurs, Maxime, Jansen, Matthijs, Vugts, Danielle J, Seijkens, Tom T P, van Dongen, Guus A M S, Lutgens, Esther, Beaino, Wissam

“…Non-invasive imaging of atherosclerosis can help in the identification of vulnerable plaque lesions. CD40 is a co-stimulatory molecule present on various…”
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Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor by Högnäsbacka, Antonia A., Poot, Alex J., Plisson, Christophe, Bergare, Jonas, Bonsall, David R., McCluskey, Stuart P., Wells, Lisa A., Kooijman, Esther, Schuit, Robert C., Verlaan, Mariska, Beaino, Wissam, van Dongen, Guus A. M. S., Vugts, Danielle J., Elmore, Charles S., Passchier, Jan, Windhorst, Albert D.

“…Background Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase…”
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Cergutuzumab amunaleukin (CEA-IL2v), a CEA-targeted IL-2 variant-based immunocytokine for combination cancer immunotherapy: Overcoming limitations of aldesleukin and conventional IL-2-based immunocytokines by Klein, Christian, Waldhauer, Inja, Nicolini, Valeria G., Freimoser-Grundschober, Anne, Nayak, Tapan, Vugts, Danielle J., Dunn, Claire, Bolijn, Marije, Benz, Jörg, Stihle, Martine, Lang, Sabine, Roemmele, Michaele, Hofer, Thomas, van Puijenbroek, Erwin, Wittig, David, Moser, Samuel, Ast, Oliver, Brünker, Peter, Gorr, Ingo H., Neumann, Sebastian, de Vera Mudry, Maria Cristina, Hinton, Heather, Crameri, Flavio, Saro, Jose, Evers, Stefan, Gerdes, Christian, Bacac, Marina, van Dongen, Guus, Moessner, Ekkehard, Umaña, Pablo

“…We developed cergutuzumab amunaleukin (CEA-IL2v, RG7813), a novel monomeric CEA-targeted immunocytokine, that comprises a single IL-2 variant (IL2v) moiety…”
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Molecular imaging predicts lack of T-DM1 response in advanced HER2-positive breast cancer (final results of ZEPHIR trial) by Mileva, Magdalena, de Vries, Elisabeth G. E., Guiot, Thomas, Wimana, Zéna, Deleu, Anne-Leen, Schröder, Carolien P., Lefebvre, Yolene, Paesmans, Marianne, Stroobants, Sigrid, Huizing, Manon, Aftimos, Philippe, Tol, Jolien, Van der Graaf, Winette T. A., Oyen, Wim J. G., Vugts, Danielle J., Menke-van der Houven van Oordt, C. Willemien, Brouwers, Adrienne H., Piccart-Gebhart, Martine, Flamen, Patrick, Gebhart, Géraldine

“…Efficacy of the human epidermal growth factor receptor (HER)2-targeting trastuzumab emtansine (T-DM1) in breast cancer (BC) relies on HER2 status determined by…”
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The biodistribution and clearance of AlbudAb, a novel biopharmaceutical medicine platform, assessed via PET imaging in humans by Thorneloe, Kevin S., Sepp, Armin, Zhang, Sean, Galinanes-Garcia, Laura, Galette, Paul, Al-Azzam, Wasfi, Vugts, Danielle J., van Dongen, Guus, Elsinga, Phillip, Wiegers, Johan, Glaudemans, Andor W. J. M., Vincent, Veena, Renaux, Jessica, Szapacs, Matt, Birchler, Mary, Cleveland, Matthew, Bergstrom, Mats, Davies, Marie

“…Conjugation or fusion to AlbudAbs™ (albumin-binding domain antibodies) is a novel approach to extend the half-life and alter the tissue distribution of…”
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