Search Results - "Vucur, Mihael"

The Role of miRNAs in the Pathophysiology of Liver Diseases and Toxicity by Schueller, Florian, Roy, Sanchari, Vucur, Mihael, Trautwein, Christian, Luedde, Tom, Roderburg, Christoph

“…Both acute and chronic liver toxicity represents a major global health burden and an important cause of morbidity and lethality worldwide. Despite epochal…”
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Necroptosis microenvironment directs lineage commitment in liver cancer by Seehawer, Marco, Heinzmann, Florian, D’Artista, Luana, Harbig, Jule, Roux, Pierre-François, Hoenicke, Lisa, Dang, Hien, Klotz, Sabrina, Robinson, Lucas, Doré, Grégory, Rozenblum, Nir, Kang, Tae-Won, Chawla, Rishabh, Buch, Thorsten, Vucur, Mihael, Roth, Mareike, Zuber, Johannes, Luedde, Tom, Sipos, Bence, Longerich, Thomas, Heikenwälder, Mathias, Wang, Xin Wei, Bischof, Oliver, Zender, Lars

“…Primary liver cancer represents a major health problem. It comprises hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ…”
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Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury by Baeck, Christer, Wehr, Alexander, Karlmark, Karlin Raja, Heymann, Felix, Vucur, Mihael, Gassler, Nikolaus, Huss, Sebastian, Klussmann, Sven, Eulberg, Dirk, Luedde, Tom, Trautwein, Christian, Tacke, Frank

“…Monocyte chemoattractant protein-1 (MCP-1, CCL2), the primary ligand for chemokine receptor C-C chemokine receptor 2 (CCR2), is increased in livers of patients…”
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Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis by Roderburg, Christoph, Urban, Gerd‐Willem, Bettermann, Kira, Vucur, Mihael, Zimmermann, Henning, Schmidt, Sabine, Janssen, Jörn, Koppe, Christiane, Knolle, Percy, Castoldi, Mirco, Tacke, Frank, Trautwein, Christian, Luedde, Tom

“…Liver fibrosis is orchestrated by a complex network of signaling pathways regulating the deposition of extracellular matrix proteins during fibrogenesis…”
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A positive feedback loop between RIP3 and JNK controls non‐alcoholic steatohepatitis by Gautheron, Jérémie, Vucur, Mihael, Reisinger, Florian, Cardenas, David Vargas, Roderburg, Christoph, Koppe, Christiane, Kreggenwinkel, Karina, Schneider, Anne Theres, Bartneck, Matthias, Neumann, Ulf Peter, Canbay, Ali, Reeves, Helen Louise, Luedde, Mark, Tacke, Frank, Trautwein, Christian, Heikenwalder, Mathias, Luedde, Tom

“…Non‐alcoholic fatty liver disease (NAFLD) represents the most common liver disease in Western countries and often progresses to non‐alcoholic steatohepatitis…”
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TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation by Labiano, Ibone, Agirre-Lizaso, Aloña, Olaizola, Paula, Echebarria, Anne, Huici-Izagirre, Maider, Olaizola, Irene, Esparza-Baquer, Aitor, Sharif, Omar, Hijona, Elizabeth, Milkiewicz, Piotr, Milkiewicz, Malgorzata, González-Romero, Francisco, Aspichueta, Patricia, Monte, Maria J., Marin, Jose J.G., Vucur, Mihael, Luedde, Tom, Marzioni, Marco, Mann, Derek A., Bujanda, Luis, Rodrigues, Pedro M., Banales, Jesus M., Perugorria, Maria J.

“…Inflammation, particularly that mediated by bacterial components translocating from the gut to the liver and binding to toll-like receptors (TLRs), is central…”
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Histidine‐rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease by Bartneck, Matthias, Fech, Viktor, Ehling, Josef, Govaere, Olivier, Warzecha, Klaudia Theresa, Hittatiya, Kanishka, Vucur, Mihael, Gautheron, Jérémie, Luedde, Tom, Trautwein, Christian, Lammers, Twan, Roskams, Tania, Jahnen‐Dechent, Willi, Tacke, Frank

“…Pathogen‐ and injury‐related danger signals as well as cytokines released by immune cells influence the functional differentiation of macrophages in chronic…”
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Circulating microRNA-150 serum levels predict survival in patients with critical illness and sepsis by Roderburg, Christoph, Luedde, Mark, Vargas Cardenas, David, Vucur, Mihael, Scholten, David, Frey, Norbert, Koch, Alexander, Trautwein, Christian, Tacke, Frank, Luedde, Tom

“…Down-regulation of miR-150 was recently linked to inflammation and bacterial infection. Furthermore, reduced serum levels of miR-150 were reported from a small…”
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Serum levels of miR-29, miR-122, miR-155 and miR-192 are elevated in patients with cholangiocarcinoma by Loosen, Sven H, Lurje, Georg, Wiltberger, Georg, Vucur, Mihael, Koch, Alexander, Kather, Jakob N, Paffenholz, Pia, Tacke, Frank, Ulmer, Florian T, Trautwein, Christian, Luedde, Tom, Neumann, Ulf P, Roderburg, Christoph

“…Cholangiocarcinoma (CCA) represents the second most common primary hepatic malignancy. Despite tremendous research activities, the prognosis for the majority…”
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miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene Nfib by Roy, Sanchari, Bantel, Heike, Wandrer, Franziska, Theres Schneider, Anne, Gautheron, Jeremie, Vucur, Mihael, Tacke, Frank, Trautwein, Christian, Luedde, Tom, Roderburg, Christoph

“…Graphical abstract…”
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Down-regulation of miR-192-5p protects from oxidative stress-induced acute liver injury by Roy, Sanchari, Benz, Fabian, Alder, Jan, Bantel, Heike, Janssen, Joern, Vucur, Mihael, Gautheron, Jeremie, Schneider, Anne, Schüller, Florian, Loosen, Sven, Luedde, Mark, Koch, Alexander, Tacke, Frank, Luedde, Tom, Trautwein, Christian, Roderburg, Christoph

“…miR-192-5p has gained increasing relevance in various diseases, however, its function in acute liver injury is currently unknown. We analysed miR-192-5p serum…”
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Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases by Roderburg, Christoph, Benz, Fabian, Vargas Cardenas, David, Koch, Alexander, Janssen, Joern, Vucur, Mihael, Gautheron, Jeremie, Schneider, Anne T., Koppe, Christiane, Kreggenwinkel, Karina, Zimmermann, Henning W., Luedde, Mark, Trautwein, Christian, Tacke, Frank, Luedde, Tom

“…Background & Aims Serum concentrations of miR‐122 were proposed as a marker for various inflammatory diseases, but the mechanisms driving alterations in…”
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Serum levels of circulating microRNA-107 are elevated in patients with early-stage HCC by Loosen, Sven H, Castoldi, Mirco, Jördens, Markus S, Roy, Sanchary, Vucur, Mihael, Kandler, Jennis, Hammerich, Linda, Mohr, Raphael, Tacke, Frank, Ulmer, Tom F, Neumann, Ulf P, Luedde, Tom, Roderburg, Christoph

“…Early detection of hepatocellular carcinoma (HCC), the most common primary liver malignancy, is crucial to offer patients a potentially curative treatment…”
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Micro-RNA profiling in human serum reveals compartment-specific roles of miR-571 and miR-652 in liver cirrhosis by Roderburg, Christoph, Mollnow, Tobias, Bongaerts, Brenda, Elfimova, Natalia, Vargas Cardenas, David, Berger, Katharina, Zimmermann, Henning, Koch, Alexander, Vucur, Mihael, Luedde, Mark, Hellerbrand, Claus, Odenthal, Margarete, Trautwein, Christian, Tacke, Frank, Luedde, Tom

“…Micro-RNAs (miRNAs) have recently emerged as crucial modulators of molecular processes involved in chronic liver diseases. The few miRNAs with previously…”
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IL-6 and IL-8 Serum Levels Predict Tumor Response and Overall Survival after TACE for Primary and Secondary Hepatic Malignancies by Loosen, Sven H, Schulze-Hagen, Maximilian, Leyh, Catherine, Benz, Fabian, Vucur, Mihael, Kuhl, Christiane, Trautwein, Christian, Tacke, Frank, Bruners, Philipp, Roderburg, Christoph, Luedde, Tom

“…While surgical resection represents the standard potentially curative therapy for liver cancer, transarterial chemoembolization (TACE) has evolved as a…”
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CT-based determination of excessive visceral adipose tissue is associated with an impaired survival in critically ill patients by Wirtz, Theresa H, Loosen, Sven H, Schulze-Hagen, Maximilian, Weiskirchen, Ralf, Buendgens, Lukas, Abu Jhaisha, Samira, Brozat, Jonathan F, Puengel, Tobias, Vucur, Mihael, Paffenholz, Pia, Kuhl, Christiane, Tacke, Frank, Trautwein, Christian, Luedde, Tom, Roderburg, Christoph, Koch, Alexander

“…Obesity is a negative prognostic factor for various clinical conditions. In this observational cohort study, we evaluated a CT-based assessment of the adipose…”
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Serum levels of bone sialoprotein correlate with portal pressure in patients with liver cirrhosis by Benz, Fabian, Bogen, Andreas, Praktiknjo, Michael, Jansen, Christian, Meyer, Carsten, Wree, Alexander, Demir, Muenevver, Loosen, Sven, Vucur, Mihael, Schierwagen, Robert, Tacke, Frank, Trebicka, Jonel, Roderburg, Christoph

“…Liver cirrhosis represents the common end-stage of chronic liver diseases regardless of its etiology. Patients with compensated disease are mostly…”
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RIP3 Inhibits Inflammatory Hepatocarcinogenesis but Promotes Cholestasis by Controlling Caspase-8- and JNK-Dependent Compensatory Cell Proliferation by Vucur, Mihael, Reisinger, Florian, Gautheron, Jérémie, Janssen, Joern, Roderburg, Christoph, Cardenas, David Vargas, Kreggenwinkel, Karina, Koppe, Christiane, Hammerich, Linda, Hakem, Razq, Unger, Kristian, Weber, Achim, Gassler, Nikolaus, Luedde, Mark, Frey, Norbert, Neumann, Ulf Peter, Tacke, Frank, Trautwein, Christian, Heikenwalder, Mathias, Luedde, Tom

“…For years, the term “apoptosis” was used synonymously with programmed cell death. However, it was recently discovered that receptor interacting protein 3…”
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Elevated Serum Levels of CCL23 Are Associated with Poor Outcome after Resection of Biliary Tract Cancer by Roderburg, Christoph, Labuhn, Simon, Bednarsch, Jan, Lang, Sven A., Schneider, Anne T., Hammerich, Linda, Vucur, Mihael, Ulmer, Tom F., Neumann, Ulf P., Luedde, Tom, Loosen, Sven H.

“…Background. Surgical tumor resection is the only potentially curative treatment option for patients with biliary tract cancer (BTC). However, 5-year survival…”
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Circulating levels of microRNA193a-5p predict outcome in early stage hepatocellular carcinoma by Loosen, Sven H, Wirtz, Theresa H, Roy, Sanchari, Vucur, Mihael, Castoldi, Mirco, Schneider, Anne T, Koppe, Christiane, Ulmer, Tom F, Roeth, Anjali A, Bednarsch, Jan, Alizai, Patrick H, Paffenholz, Pia, Demir, Münevver, Trautwein, Christian, Tacke, Frank, Neumann, Ulf P, Roderburg, Christoph, Luedde, Tom

“…While tumor resection and liver transplantation (LT) represent potentially curative therapeutic options for patients with early-stage hepatocellular carcinoma…”
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