Hyperbaric oxygen is effective in early stage of healing of experimental brain abscess in rats

Hyperbaric oxygen is effective in early stage of healing of experimental brain abscess in rats

Objectives: Current therapy of brain abscess (BA) includes a combined approach that involves antibiotics and minimal invasive surgery, but also hyperbaric oxygen treatment (HBOT) as a supportive measure. Optimum treatment is still a matter of significant controversy. Methods: The experiment, previou...

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Bibliographic Details
Published in:Neurological research (New York) Vol. 34; no. 10; pp. 931 - 936
Main Authors: Bilic, Ivica, Petri, Nadan M, Krstulja, Mira, Vuckovic, Meri, Salamunic, Ilza, Kraljevic, Katarina Sisko, Capkun, Vesna, Lusic, Ivo
Format: Journal Article
Language:English
Published: England Taylor & Francis 01-12-2012
Subjects:
Animals
Brain abscess
Brain Abscess - microbiology
Brain Abscess - therapy
Disease Models, Animal
Experimental model
Female
Healing
Hyperbaric oxygen
Hyperbaric Oxygenation - methods
Neoangiogenesis
Random Allocation
Rats
Rats, Wistar
Staphyloccocus aureus
Staphylococcal Infections - metabolism
Staphylococcal Infections - therapy
Staphylococcus aureus
Time Factors
Treatment Outcome
Wound Healing - physiology
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Summary:Objectives: Current therapy of brain abscess (BA) includes a combined approach that involves antibiotics and minimal invasive surgery, but also hyperbaric oxygen treatment (HBOT) as a supportive measure. Optimum treatment is still a matter of significant controversy. Methods: The experiment, previously approved by a relevant ethical committee, involved 80 female Wistar rats. BA was experimentally induced by inoculation of Staphyloccocus aureus. The animals were randomized into groups and treated either with antibiotics, HBOT, or with a combination of both. Results: Beneficial effect of HBOT was evident in groups treated with HBOT or with a combination of antibiotic+HBOT. It was mainly manifested on days three and five of the experiment and was evident as statistically significant increase of a number of newly formed blood vessels, increase in mean vascular density, and smaller abscess necrotic core. Discussion: Although the results of the present study should be interpreted cautiously, they suggest that HBOT has an important but limited role in the treatment of BA.
Bibliography:ObjectType-Article-1
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ISSN:0161-6412
1743-1328
DOI:10.1179/1743132812Y.0000000091